PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

scientific journal article

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.00310-08
P3181OpenCitations bibliographic resource ID2666889
P932PMC publication ID2423144
P698PubMed publication ID18332125

P2093author name stringHong Wu
Bahram Valamehr
Sherly Mosessian
Chun-Ju Chang
David J. Mulholland
William R. Sellers
P2860cites workThreonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ bindingQ22011155
Phosphorylation of the PTEN tail regulates protein stability and functionQ22254305
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradationQ24290417
Ubiquitination regulates PTEN nuclear import and tumor suppressionQ24292946
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeastQ24336385
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisQ24540387
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanismsQ28181035
PTEN: one gene, many syndromesQ28203387
The biology and clinical relevance of the PTEN tumor suppressor pathwayQ28272157
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifsQ28564702
Live or let die: the cell's response to p53Q29547663
A role for nuclear PTEN in neuronal differentiation.Q29568319
The antioxidant function of the p53 tumor suppressorQ29619231
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Diet, androgens, oxidative stress and prostate cancer susceptibilityQ33715166
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activityQ33774967
The multiple roles of PTEN in tumor suppressionQ33849727
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complexQ34101673
Cellular response to oxidative stress: signaling for suicide and survivalQ34138566
Regulation of PTEN by Rho small GTPasesQ34406790
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein networkQ34825957
Human cancer, PTEN and the PI-3 kinase pathwayQ35812408
Identification of a tumour suppressor network opposing nuclear Akt functionQ35991130
Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascadeQ40050501
A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growthQ40184782
The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulationQ40254270
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3betaQ40384036
PTEN enters the nucleus by diffusionQ40387100
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault proteinQ40421181
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapyQ40765673
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulationQ42076186
Changes in endometrial PTEN expression throughout the human menstrual cycleQ42489118
PTEN regulates Mdm2 expression through the P1 promoterQ44848220
Mechanistic insights into maintenance of high p53 acetylation by PTEN.Q46035699
Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanomaQ57591227
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia preventionQ59067116
[PTEN tumor suppressor: functions as a lipid phosphatase]Q73124101
Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cellsQ78834996
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectoxidative stressQ898814
Transformation related protein 53Q14818136
Phosphatase and tensin homologQ14878408
P304page(s)3281–3289
P577publication date2008-05-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlePTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression
P478volume28

Reverse relations

cites work (P2860)
Q28546443A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity
Q33374003A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans
Q35853239ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells
Q42496198Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes
Q33740171Allele-specific tumor spectrum in pten knockin mice
Q37431681Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex
Q36942597Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location
Q37734730Anti-diabetic effect of Alpinia oxyphylla extract on 57BL/KsJ db-/db- mice
Q52578386Calcium and Nuclear Signaling in Prostate Cancer.
Q39080461Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease
Q39365401Cell Cycle Control by PTEN.
Q34079578Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line
Q55068347Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.
Q34481443Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair
Q30363869Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Q34673451Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation
Q38160495Disruption of prostate epithelial differentiation pathways and prostate cancer development
Q42383055Does PTEN gene mutation play any role in Li-Fraumeni syndrome
Q37400322Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas.
Q64271866Effect of PTEN loss on metabolic reprogramming in prostate cancer cells
Q24622802Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
Q37708388Establishment of a novel cellular model for myxofibrosarcoma heterogeneity
Q92028215Hepatocellular Toxicity of Paris Saponins I, II, VI and VII on Two Kinds of Hepatocytes-HL-7702 and HepaRG Cells, and the Underlying Mechanisms
Q46835597Hypoxic culture conditions enhance the generation of regulatory T cells
Q38275632Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach
Q37052883Inactivation of specific β cell transcription factors in type 2 diabetes
Q39297251Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN.
Q28586708Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells
Q38266259Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?
Q42203006Loss of nuclear PTEN in HCV-infected human hepatocytes
Q34876968MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation
Q39093841Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Q92906114Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions
Q92207064Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus
Q24316324Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response
Q38206143Non-cell autonomous or secretory tumor suppression
Q42218359Nongenomic Mechanisms of PTEN Regulation
Q39159757Nuclear phosphoinositide regulation of chromatin.
Q33636764Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.
Q38733049Nuclear transport: a switch for the oxidative stress-signaling circuit?
Q26862544PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms
Q47435142PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.
Q92702101PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?
Q30475282PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse
Q37977769PTEN in DNA damage repair
Q35349562PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation
Q37606460PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress
Q24337070PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha
Q50977901PTEN, Longevity and Age-Related Diseases.
Q37955889PTEN-Associated Complexes: An Overview.
Q33920955PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity.
Q37270432PTEN: a new guardian of the genome.
Q42921293PTENtumor suppressor plays less prognostic role thanP53tumor suppressor in diffuse large B-cell lymphoma
Q35235757Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma
Q27012953Phosphoinositides: tiny lipids with giant impact on cell regulation
Q35918916Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
Q34979078Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification
Q33769079Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease
Q35064623SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
Q36638098Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression
Q36995054Targeting prostate cancer based on signal transduction and cell cycle pathways.
Q36137883The Optimization of Soluble PTEN Expression in Escherichia coli
Q30500308The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer.
Q90480486The oncogenic role of microRNA-500a in colorectal cancer
Q37270446The role of PTEN signaling perturbations in cancer and in targeted therapy
Q34540302The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3K/Akt pathway
Q48362692The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
Q92854358Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition
Q38271796Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma
Q64092698Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress

Search more.