Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons

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Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...618857M
P356DOI10.1371/JOURNAL.PONE.0018857
P932PMC publication ID3084716
P698PubMed publication ID21559530
P5875ResearchGate publication ID51114598

P2093author name stringVera L Moncalero
Claudia Perandones
Martin Radrizzani
Roxana V Costanzo
P2860cites workBinding of disease-associated prion protein to plasminogen.Q52541671
Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanomaQ57591227
PTENQ74257316
Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinomaQ77879703
Nuclear PTEN: a tale of many tailsQ79448445
The lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Ubiquitination regulates PTEN nuclear import and tumor suppressionQ24292946
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymeraseQ27860794
In vitro selection of RNA molecules that bind specific ligandsQ27861109
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
A role for nuclear PTEN in neuronal differentiation.Q29568319
Development of monoclonal oligobodies and chemically synthesized oligobodiesQ30661721
Generation of species cross-reactive aptamers using "toggle" SELEX.Q30773712
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathwayQ30829981
Oligobodies: bench made synthetic antibodies.Q30855050
SELEX experiments: new prospects, applications and data analysis in inferring regulatory pathwaysQ31109037
Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse modelsQ33533301
The multiple roles of PTEN in tumor suppressionQ33849727
Structural basis of T cell recognition of peptides bound to MHC moleculesQ34602699
Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cellsQ35745875
Evaluation of non-formalin tissue fixation for molecular profiling studiesQ35747288
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancersQ35747653
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breastQ35788322
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumorsQ35810225
Class reunion: PTEN joins the nuclear crew.Q36313163
Nuclear Ptdlns(3,4,5)P3 signaling: an ongoing storyQ36463127
PTEN enters the nuclear age.Q36705731
ATP modulates PTEN subcellular localization in multiple cancer cell lines.Q36851633
The nuclear affairs of PTEN.Q37063858
Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.Q37252731
RNA aptamers specifically interact with the prion protein PrP.Q38342284
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML networkQ39948774
Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascadeQ40050501
A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growthQ40184782
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.Q40198370
PTEN enters the nucleus by diffusionQ40387100
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault proteinQ40421181
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosisQ40770781
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.Q42807725
SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear specklesQ44504090
Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain developmentQ45036615
Mechanistic insights into maintenance of high p53 acetylation by PTEN.Q46035699
Pathologic prion protein is specifically recognized in situ by a novel PrP conformational antibody.Q48459693
Polyacrylamide gel electrophoresis and immunoblotting of proteins extracted from paraffin-embedded tissue sections.Q50896429
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcytoplasmQ79899
P304page(s)e18857
P577publication date2011-04-29
P1433published inPLOS OneQ564954
P1476titleDifferent conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons
P478volume6

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cites work (P2860)
Q90047400Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer
Q36636425Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN.
Q37099496In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1-/- alters PTEN and NHERF1 but not β-catenin expression.
Q54979591Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
Q33700800Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.
Q27022790Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders