Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma

scientific article published on March 2001

Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1035871535
P356DOI10.1054/BJOC.2000.1660
P8608Fatcat IDrelease_2tzqqma7trhohd6243y6vfl2fy
P932PMC publication ID2363812
P698PubMed publication ID11259087
P5875ResearchGate publication ID12073731

P2093author name stringG Thomas
H Wang
R D Odze
C Eng
M H Kulke
M Loda
K S Thakore
P2860cites workP-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancersQ28145813
PTEN1 is frequently mutated in primary endometrial carcinomasQ28250937
MMAC1/PTEN mutations in primary tumor specimens and tumor cell linesQ28256046
Role of the p16 tumor suppressor gene in cancerQ28265169
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Q30472730
Germline PTEN mutations in Cowden syndrome-like families.Q33681468
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancerQ34436736
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndromeQ34504165
Epigenetic PTEN silencing in malignant melanomas without PTEN mutationQ35745799
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumorsQ35810225
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sitesQ36115450
Somatic mutation of PTEN in bladder carcinomaQ36617723
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.Q36618853
Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomasQ36618879
Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.Q36619048
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancersQ36951846
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.Q38467346
Low p27 expression predicts poor disease-free survival in patients with prostate cancerQ38472792
Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinomaQ38530938
Mutation analysis of the p53, APC, and p16 genes in the Barrett's oesophagus, dysplasia, and adenocarcinomaQ39563836
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTENQ39711051
Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinomaQ40907210
PTEN gene alterations in lymphoid neoplasmsQ41000268
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.Q42815905
Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell linesQ42818580
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinomaQ43725713
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.Q44846579
Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphomaQ47712787
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancersQ47720095
Mutational analysis of the PTEN gene in head and neck squamous cell carcinomaQ47751177
PTEN/MMAC1/TEP1 involvement in primary prostate cancers.Q47814101
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancersQ47814180
Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomasQ47814647
PTEN mutations in gliomas and glioneuronal tumors.Q47995275
Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.Q48030071
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlationsQ48252490
Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancersQ48464018
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.Q48544624
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.Q48566471
Somatic mutations of PTEN in glioblastoma multiformeQ48618632
Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.Q52537916
Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.Q52540667
PTEN/MMAC1 mutations in endometrial cancers.Q53439663
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.Q53439669
Mutations of p53 in Barrett's esophagus and Barrett's cancer: a prospective study of ninety-eight cases.Q53457025
Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas.Q55477059
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.Q55477977
PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.Q55478126
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignanciesQ57591287
Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal AdenocarcinomaQ58204833
TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagusQ58409008
Expression of p53 protein in oesophageal carcinoma: clinicopathological correlation and prognostic significanceQ60632753
Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancersQ67920829
Rising incidence of adenocarcinoma of the esophagus and gastric cardiaQ68199481
Allelotype analysis of esophageal adenocarcinomas: evidence for the involvement of sequences on the long arm of chromosome 4Q71545574
Base transitions at CpG dinucleotides in the p53 gene are common in esophageal adenocarcinomaQ71887355
p53 protein expression in Barrett's adenocarcinoma: a frequent event with no prognostic significanceQ72195645
p53 mutations in Barrett's adenocarcinoma and high-grade dysplasiaQ72463048
The MTS1 gene is frequently mutated in primary human esophageal tumorsQ72831620
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomasQ73221172
Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotypeQ73316223
Allelic imbalance and mutations of the PTEN gene in ovarian cancerQ73340878
Loss of heterozygosity on chromosome 9 andp16 (MTS1, CDKN2) gene mutations in esophageal cancersQ73486608
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignanciesQ73722520
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndromeQ73883821
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissuesQ74093343
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locusQ74274255
Analysis of PTEN and the 10q23 region in primary prostate carcinomasQ74531155
Alterations of the MMAC1/PTEN gene in lymphoid malignanciesQ74576991
PTEN mutations in endometrial cancers with 10q LOH: additional evidence for the involvement of multiple tumor suppressorsQ77789624
Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosisQ77995588
Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancerQ78206096
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)748-753
P577publication date2001-03-01
P1433published inBritish Journal of CancerQ326309
P1476titleAllelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma
P478volume84

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cites work (P2860)
Q33287238Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study
Q39698340Assessment of mutational load in biopsy tissue provides additional information about genomic instability to histological classifications of Barrett's esophagus.
Q49816565Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma.
Q40203442Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma
Q33449893Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences
Q57591227Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
Q43456119Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China

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