PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer

scientific article (December 2011)

PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.AJPATH.2011.11.021
P932PMC publication ID3349886
P698PubMed publication ID22209699
P5875ResearchGate publication ID51973035

P50authorR. Daniel BonfilQ67488266
M. Katie Conley-LaCombQ93138508
Hyeong-Reh Choi KimQ116796852
P2093author name stringWei Huang
Michael L Cher
Shihua Wang
Yong Q Chen
Young Suk Jung
Rafael Fridman
Dongping Shi
Abdo Najy
P2860cites workThe tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cellsQ24531982
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acidsQ24674656
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationQ24677034
Cancer statistics, 2010Q27860525
PDGF-D, a new protease-activated growth factorQ28186722
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
Reduction of Akt2 inhibits migration and invasion of glioma cellsQ28572665
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancerQ28590839
TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including gliomaQ28740616
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activityQ30434033
The multiple roles of PTEN in tumor suppressionQ33849727
Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration.Q52175351
Gene expression correlates of clinical prostate cancer behaviorQ60156349
Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomasQ71652817
Platelet-derived growth factor A and B chains and the alpha and beta receptors in prostatic intraepithelial neoplasiaQ71740261
Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathwaysQ73248309
Impaired vascular invasion of Cbfa1-deficient cartilage engrafted in the spleenQ74407916
PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cellsQ81877328
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptorQ33945092
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.Q33997854
Induction and regulation of epithelial-mesenchymal transitionsQ34047215
Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeatsQ34104733
A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progressionQ34224640
A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancerQ34683885
Platelet-derived growth factor signaling and human cancerQ35051106
Practical management of patients with chronic myeloid leukemia receiving imatinibQ35095956
Smart drugs in prostate cancerQ35604827
Indications for imatinib mesylate therapy and clinical managementQ35787974
Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptorQ35788293
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumorsQ35810225
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancerQ36178164
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.Q36301565
Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathwaysQ36313178
Characterization of adult prostatic progenitor/stem cells exhibiting self-renewal and multilineage differentiationQ36713740
Tenets of PTEN tumor suppressionQ37154214
AMPK: a key regulator of energy balance in the single cell and the whole organism.Q37249357
PTEN and the PI3-kinase pathway in cancerQ37259680
AMP-activated protein kinase promotes human prostate cancer cell growth and survivalQ37415957
A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancerQ38461620
AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxiaQ39545841
Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastasesQ39644572
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTENQ39711051
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.Q39863992
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.Q40021818
Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinomaQ40282981
AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastomaQ40308352
Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.Q40473451
Antitumor effects of thalidomide analogs in human prostate cancer xenografts implanted in immunodeficient miceQ40541637
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.Q40590650
Platelet-derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factorQ40754782
Transforming growth factor-beta1-induced proliferation of the prostate cancer cell line, TSU-Pr1: the role of platelet-derived growth factorQ40937791
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulationQ42076186
Culture of mouse prostatic epithelial cells from genetically engineered miceQ42471864
The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growthQ42806622
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cellsQ44737517
Differential growth factor control of bone formation through osteoprogenitor differentiationQ44788381
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude miceQ44942702
Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cellsQ45231176
Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastasesQ46972241
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)1017-1027
P577publication date2011-12-28
P1433published inThe American Journal of PathologyQ4744259
P1476titlePTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer
P478volume180

Reverse relations

cites work (P2860)
Q37035984A critical role of the PTEN/PDGF signaling network for the regulation of radiosensitivity in adenocarcinoma of the prostate
Q38673563DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis
Q37593021Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer
Q26859634Emerging roles of PDGF-D in EMT progression during tumorigenesis
Q46823306Functional regulation of adipose-derived stem cells by PDGF-D.
Q41967756High expression of PDGFR-β in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence
Q97681363Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis
Q37610084Neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis
Q37116576PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling
Q39424549Prostate Cancer Stem Cell Markers Drive Progression, Therapeutic Resistance, and Bone Metastasis
Q34302881Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.
Q39150840Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling.
Q34393461Targeting the PDGF signaling pathway in tumor treatment
Q38806364The interaction between androgen receptor and PDGF-D in the radiation response of prostate carcinoma.
Q37615017The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer
Q38160946Therapeutic targeting of platelet-derived growth factor receptors in solid tumors

Search more.