Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer

scientific article

Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3748/WJG.V10.I21.3225
P932PMC publication ID4611280
P698PubMed publication ID15457582
P5875ResearchGate publication ID283585277

P2093author name stringWei Fan
De Shi
Tong Zhou
Xiao-Ting Wu
Yue-Chun Li
Xiong Huang
Ye-Jiang Zhou
Yu-Xia Xiong
P2860cites workThe tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
Protean PTEN: form and functionQ24613810
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancersQ28145813
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cellsQ28344025
Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovaryQ30649065
Tissue expression of VEGF as a prognostic factor in early cervical squamous cell carcinomaQ31036915
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesisQ33723736
PTEN controls tumor-induced angiogenesisQ35282160
Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinomaQ36179792
Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.Q36619048
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cellsQ37116110
Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesisQ40679766
PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell linesQ40833639
Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.Q40916972
MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.Q42825696
Promoter methylation and silencing of PTEN in gastric carcinomaQ43918868
Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relativesQ43959642
Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancerQ43966008
The effects of PTEN gene on migration and FAK phosphorylation of SMMC-7721 human hepatocarcinoma cell lineQ44289639
Tumour suppressor gene expression correlates with gastric cancer prognosisQ44401645
PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpusQ44702044
Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivoQ45869247
Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinomaQ45952675
PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastomaQ48132410
PTEN protein expression correlates with PTEN gene molecular changes but not with VEGF expression in astrocytomas.Q48204599
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.Q48230264
Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.Q48829821
Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.Q52549220
Morphometric microvascular characteristics predict prognosis in superficial and invasive bladder cancer.Q52933275
MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancerQ57648894
TGF-β1 Modulated the Expression of α5β1 Integrin and Integrin-Mediated Signaling in Human Hepatocarcinoma CellsQ57662206
Colorectal carcinomas and PTEN/MMAC1 gene mutationsQ62661743
PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effectsQ64379300
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomasQ73271272
Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesisQ73295499
10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancerQ73814904
Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinomaQ77340398
Tumor angiogenesis in lymph node-negative rectal cancer: correlation with clinicopathological parameters and prognosisQ77599299
PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulationQ78026206
Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancerQ79366153
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)3225-3229
P577publication date2004-11-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleInactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer
P478volume10

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cites work (P2860)
Q57196623A clinicopathological study of basaloid squamous carcinoma of the esophagus
Q35943250Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma
Q35915549Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development
Q48649622Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN.
Q36099292Effect of the combination of a cyclooxygenase-1 selective inhibitor and taxol on proliferation, apoptosis and angiogenesis of ovarian cancer in vivo
Q36253306Epidermal growth factor receptor and angiogenesis: Opportunities for combined anticancer strategies
Q36006472Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
Q33843200MicroRNA-382 induced by HIF-1α is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog
Q92702101PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?
Q35952035PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer
Q37394161PTEN-mediated pathways and their association with treatment-resistant prostate cancer
Q35374477Pathway profiling and rational trial design for studies in advanced stage cervical carcinoma: a review and a perspective
Q33997970Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx
Q40348015VEGF expression is associated with negative estrogen receptor status in patients with breast cancer
Q34030791YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical models