PTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy

scientific article published on 01 September 2019

PTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/HMG/DDZ112
P932PMC publication ID6735678
P698PubMed publication ID31127935

P50authorAta AbbasQ59690049
Charis EngQ37385393
P2093author name stringTodd Romigh
Roshan Padmanabhan
P2860cites workP-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryoQ24645367
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisQ24681977
Focus on PTEN RegulationQ26797287
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoansQ29394946
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.Q33705644
The RNA polymerase II CTD coordinates transcription and RNA processing.Q34303212
Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulationQ34346839
PTEN interacts with histone H1 and controls chromatin condensationQ34364654
PTEN: Multiple Functions in Human Malignant TumorsQ35087328
RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition.Q35562114
Lifetime cancer risks in individuals with germline PTEN mutations.Q35681689
Standardizing chromatin research: a simple and universal method for ChIP-seq.Q35878585
Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networksQ35945067
Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorderQ36048195
PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.Q36361389
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotypeQ36392356
The nuclear affairs of PTEN.Q37063858
Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signalsQ37352913
How slow RNA polymerase II elongation favors alternative exon skipping.Q54355333
Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role.Q55212155
Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.Q55311511
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.Q55371418
Localization of the gene for Cowden disease to chromosome 10q22–23Q57694734
Dynamic turnover of paused Pol II complexes at human promoters.Q64901530
The functions and regulation of the PTEN tumour suppressor: new modes and prospectsQ88955683
PTEN-opathies: from biological insights to evidence-based precision medicineQ90918120
PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcriptionQ37733825
The multiple layers of non-genetic regulation of PTEN tumour suppressor activityQ38140342
PTEN function: the long and the short of it.Q38198345
Directly targeting transcriptional dysregulation in cancerQ38614252
Transcriptional Addiction in Cancer.Q39130428
Cell Cycle Control by PTEN.Q39365401
The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulationQ40254270
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosisQ40372916
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiationQ42290035
Cancer risk and genotype-phenotype correlations in PTEN hamartoma tumor syndromeQ46837367
Emerging Insights into the Roles of the Paf1 Complex in Gene RegulationQ47859224
The Functional Impact of Alternative Splicing in CancerQ47883333
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop AccumulationQ49547193
PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregationQ50168053
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue17
P304page(s)2826-2834
P577publication date2019-09-01
P1433published inHuman Molecular GeneticsQ2720965
P1476titlePTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy
P478volume28

Reverse relations

Q92890429PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domaincites workP2860

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