CREB is a novel nuclear target of PTEN phosphatase

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CREB is a novel nuclear target of PTEN phosphatase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-10-3399
P932PMC publication ID3105967
P698PubMed publication ID21385900

P50authorWen Hong ShenQ60309699
P2093author name stringJianli Wang
Yuxin Yin
Zhong Zhang
Tingting Gu
Wen Hong Shen
Junyi Guo
P2860cites workPTEN: a new guardian of the genome.Q37270432
The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signalingQ39697902
Lack of PTEN sequesters CHK1 and initiates genetic instability.Q40458578
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.Q40831748
GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN.Q42834476
PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expressionQ43701623
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.Q46127758
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanismsQ28181035
CREB is a regulatory target for the protein kinase Akt/PKBQ28289946
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signalsQ29620470
PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunitQ30308560
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.Q34742581
Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulationQ36681859
PTEN enters the nuclear age.Q36705731
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2821-2825
P577publication date2011-03-08
P1433published inCancer ResearchQ326097
P1476titleCREB is a novel nuclear target of PTEN phosphatase
P478volume71

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cites work (P2860)
Q24320313A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
Q33819901ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury
Q37945234Anti-apoptotic effect of Tax: an NF-κB path or a CREB way?
Q55010335CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.
Q37983795CREB signalling in neural stem/progenitor cells: recent developments and the implications for brain tumour biology
Q39365401Cell Cycle Control by PTEN.
Q34079578Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line
Q38722053Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription
Q39000649Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.
Q38160495Disruption of prostate epithelial differentiation pathways and prostate cancer development
Q30392471Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis
Q54282770FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells.
Q91583393FBXO22 degrades nuclear PTEN to promote tumorigenesis
Q35825716Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity
Q37198882Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription
Q28581058Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells
Q91659128KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain
Q36032452Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo
Q34310220Novel Type of Prodrug Activation through a Long-Range O,N-Acyl Transfer: A Case of Water-Soluble CREB Inhibitor
Q42290035Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
Q37931279Nuclear phosphoinositides and their roles in cell biology and disease
Q49550289PTEN Inhibition in Human Disease Therapy
Q47435142PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.
Q36392356PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype
Q39201094PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells
Q36104685PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi
Q45904675PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.
Q39176925PTEN proteoforms in biology and disease
Q37166155PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
Q39615345PTEN regulates PLK1 and controls chromosomal stability during cell division
Q64940992PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.
Q35087328PTEN: Multiple Functions in Human Malignant Tumors
Q38406254PTEN: a yin-yang master regulator protein in health and disease
Q33967552Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells
Q47288494Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus
Q91675723Podocyte histone deacetylase activity regulates murine and human glomerular diseases
Q41564326Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway
Q37246521Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization
Q36542256Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs.
Q38547024Releasing 'brakes' to nerve regeneration: intrinsic molecular targets
Q36899622Role of TRPM2 in cell proliferation and susceptibility to oxidative stress
Q37417517Stem cell quiescence acts as a tumour suppressor in squamous tumours.
Q92957648Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
Q37303415Systemic Inhibition of CREB is Well-tolerated in vivo
Q36809538The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis
Q26776527The PTEN tumor suppressor gene and its role in lymphoma pathogenesis
Q37948971The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies
Q29615536The functions and regulation of the PTEN tumour suppressor
Q88955683The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Q39365663The functions of tumor suppressor PTEN in innate and adaptive immunity
Q28269344The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity
Q40417033The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation
Q35595103The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation
Q39337955Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer
Q34427403microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection
Q37188735ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes

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