Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway

scientific article published on 30 August 2017

Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway is …
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P6179Dimensions Publication ID1091344506
P356DOI10.1038/S41598-017-09707-Y
P932PMC publication ID5577102
P698PubMed publication ID28855544

P50authorYing-Ju LaiQ87980068
Gwo-Jyh ChangQ90264027
Hsao-Hsun HsuQ58437828
P2093author name stringWei-Jan Chen
Chung-Chi Huang
Jong-Hwei S Pang
Shu-Hui Lin
P2860cites workDiabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration.Q43740242
Protective effect of propylthiouracil independent of its hypothyroid effect on atherogenesis in cholesterol-fed rabbits: PTEN induction and inhibition of vascular smooth muscle cell proliferation and migrationQ45027911
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferationQ45121964
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertensionQ45869636
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertensionQ46604316
Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways.Q51704646
Cilostazol promotes vascular smooth muscles cell differentiation through the cAMP response element-binding protein-dependent pathway.Q53240012
Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.Q53492244
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cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migrationQ74523107
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Suppressive effect of prostaglandin E1 on pulmonary hypertension induced by monocrotaline in ratsQ77938909
PCAF modulates PTEN activityQ24296629
Notch3 signaling promotes the development of pulmonary arterial hypertensionQ24310736
Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanismQ24315753
Molecular pathogenesis of pulmonary arterial hypertensionQ24634317
Beta-adrenergic receptor activation in immortalized human urothelial cells stimulates inflammatory responses by PKA-independent mechanismsQ24810781
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungsQ28218337
Suppression of Akt1 phosphorylation by adenoviral transfer of the PTEN gene inhibits hypoxia-induced proliferation of rat pulmonary arterial smooth muscle cellsQ28581008
The functions and regulation of the PTEN tumour suppressorQ29615536
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Inhaled iloprost for severe pulmonary hypertensionQ33147955
Prostacyclin and prostaglandin E1: molecular mechanisms and therapeutic utilityQ33379657
CREB downregulation in vascular disease: a common response to cardiovascular riskQ33739408
A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat modelQ33843949
Reversal of experimental pulmonary hypertension by PDGF inhibitionQ34048479
Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinomaQ34066409
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertensionQ34589929
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CREB is a novel nuclear target of PTEN phosphataseQ35019216
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Prostanoid therapy for pulmonary arterial hypertension.Q35803359
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesisQ35898353
The nuclear affairs of PTEN.Q37063858
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertensionQ37576723
Mechanisms of disease: pulmonary arterial hypertension.Q37892336
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivationQ38340711
PLGA microparticles encapsulating prostaglandin E1-hydroxypropyl-β-cyclodextrin (PGE1-HPβCD) complex for the treatment of pulmonary arterial hypertension (PAH).Q39533415
Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse modelQ39879690
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.Q40178894
Prostanoid receptors and their biological actionsQ40815197
Dysregulation of PTEN in cardiopulmonary vascular remodeling induced by pulmonary hypertension.Q41170725
Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cellsQ41491090
Mechanisms and consequences of activation of protein kinase B/AktQ41751003
Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertensionQ41827194
Influence of PEI as a core modifying agent on PLGA microspheres of PGE₁, a pulmonary selective vasodilator.Q42775300
Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells.Q42864755
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumAuthor Correction: Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling PathwayQ90453430
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
alprostadilQ579348
P304page(s)9974
P577publication date2017-08-30
P1433published inScientific ReportsQ2261792
P1476titleProstaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway
P478volume7