Assaying PTEN catalysis in vitro

scientific article published on 13 November 2014

Assaying PTEN catalysis in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMETH.2014.11.003
P698PubMed publication ID25461809
P5875ResearchGate publication ID268752088

P50authorNick R. LeslieQ42316501
P2093author name stringLaura Spinelli
P2860cites workThrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cellsQ42982936
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascadesQ43900381
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changesQ46791213
Gold nanoparticle supported phospholipid membranes as a biomimetic biosensor platform for phosphoinositide signaling detection.Q51070219
A sensitive assay for phosphoinositide phosphatasesQ73520782
The lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionQ24295164
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanismQ27002565
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipidsQ28203936
PTEN is a protein tyrosine phosphatase for IRS1Q28239790
Protein tyrosine phosphatases in the human genomeQ28265924
A secreted PTEN phosphatase that enters cells to alter signaling and survivalQ28292188
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphataseQ28567492
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
The functions and regulation of the PTEN tumour suppressorQ29615536
A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.Q33244088
Allele-specific tumor spectrum in pten knockin miceQ33740171
A unified nomenclature and amino acid numbering for human PTEN.Q35201003
Redox regulation of PI 3-kinase signalling via inactivation of PTENQ36266420
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.Q36285541
Regulation of the PTEN phosphataseQ36468434
Understanding PTEN regulation: PIP2, polarity and protein stabilityQ37270444
The significance of PTEN's protein phosphatase activityQ37376968
Non-genomic loss of PTEN function in cancer: not in my genes.Q37828766
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.Q39774233
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.Q40198370
Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) poolQ40404816
Lipid Signaling Enzymes and Surface Dilution KineticsQ40464125
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signalQ40625753
Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6-pentakisphosphate 3-phosphatase activityQ40797555
Understanding the stereospecific interactions of 3-deoxyphosphatidylinositol derivatives with the PTEN phosphatase domainQ42712366
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extractsQ42804753
P304page(s)51-57
P577publication date2014-11-13
P1433published inMethodsQ6823859
P1476titleAssaying PTEN catalysis in vitro
P478volume77-78

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cites work (P2860)
Q87056285A rapid guide to PTEN function
Q51577097Assays to Measure PTEN Lipid Phosphatase Activity In Vitro from Purified Enzyme or Immunoprecipitates.
Q49979983Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes
Q48122312The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis.

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