Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance

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Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.102855
P932PMC publication ID2859564
P698PubMed publication ID20179324

P2093author name stringUlf Smith
Birgit Gustafson
P2860cites workInhibition of adipogenesis by Wnt signalingQ22254771
Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytesQ24304097
Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowthQ24305583
Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesisQ28115017
Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralizationQ28220576
Regulation of osteoblastogenesis and bone mass by Wnt10bQ28509048
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-cateninQ28587260
Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblastsQ28588627
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTPQ28594157
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesQ29614589
Adipocyte differentiation from the inside outQ29615690
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistanceQ29619774
The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cellsQ33817896
LRP6 mutation in a family with early coronary disease and metabolic risk factorsQ34153785
Regulation of bone mass by Wnt signalingQ34576629
Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiationQ35205402
Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association studyQ35691692
How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrowQ36167459
Adipose development: from stem cell to adipocyteQ36242589
WNT/PCP signaling pathway and human cancer (review).Q36307393
WNT signaling pathway and stem cell signaling networkQ36883377
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Wnt/Frizzled signaling in angiogenesisQ37078209
COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.Q37153650
Decreased expression of adipogenic genes in obese subjects with type 2 diabetesQ37181339
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammationQ37236239
Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation. Sequence requirement for differentiation-dependent suppressionQ38331211
Evidence of impaired adipogenesis in insulin resistanceQ38342278
Functional interaction between peroxisome proliferator-activated receptor gamma and beta-cateninQ38408437
The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblastsQ39670079
Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotypeQ39896681
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The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferationQ40225526
Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytesQ40592239
BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loopQ40621832
White fat progenitor cells reside in the adipose vasculature.Q41145314
Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.Q42027895
TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expressionQ42799282
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytesQ42805810
Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and resistinQ42829111
Life cycle of human melanocytes is regulated by endothelin-1 and stem cell factor in synergy with cyclic AMP and basic fibroblast growth factorQ43203465
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistanceQ43920014
Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.Q46956815
Wnt10b inhibits development of white and brown adipose tissuesQ47364038
Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potentialQ53512235
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectinQ59466687
Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose CellsQ73929085
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gammaQ79918319
Wnt signaling regulates transendothelial migration of monocytesQ82973206
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
P304page(s)14031-14041
P577publication date2010-02-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance
P478volume285

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