The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

scientific article published on March 23, 2012

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB11-1419
P953full work available at URLhttps://diabetes.diabetesjournals.org/content/diabetes/61/5/1217.full.pdf
https://diabetesjournals.org/diabetes/article-pdf/61/5/1217/563420/1217.pdf
https://europepmc.org/articles/PMC3331742
https://europepmc.org/articles/PMC3331742?pdf=render
https://journals.org/diabetes/diabetes/article-pdf/61/5/1217/563420/1217.pdf
P932PMC publication ID3331742
P698PubMed publication ID22447857
P5875ResearchGate publication ID221976551

P50authorUlf SmithQ56809371
P2093author name stringBirgit Gustafson
P2860cites workRegulation of Wnt signaling during adipogenesisQ24299414
Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytesQ24304097
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexQ29547208
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The roles of Wnt antagonists Dkk1 and sFRP4 during adipogenesis of human adipose tissue-derived mesenchymal stem cellsQ51945868
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectinQ59466687
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesQ29614589
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Adipocyte turnover: relevance to human adipose tissue morphologyQ33556451
Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesityQ33818062
Genetic Predisposition for Type 2 Diabetes, but Not for Overweight/Obesity, Is Associated with a Restricted AdipogenesisQ33885827
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistanceQ33930808
Activin a plays a critical role in proliferation and differentiation of human adipose progenitorsQ34119609
Regulation of bone mass by Wnt signalingQ34576629
Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene.Q35016478
Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiationQ35205402
Obesity-associated improvements in metabolic profile through expansion of adipose tissueQ35945161
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitusQ36111074
Adipose development: from stem cell to adipocyteQ36242589
Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte LineagesQ36256208
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineageQ36448097
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and diseaseQ37102953
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammationQ37236239
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesityQ37317464
New factors controlling the balance between osteoblastogenesis and adipogenesis.Q37899993
Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populationsQ39611416
Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistanceQ39735987
Wnt signaling and adipocyte lineage commitmentQ39991237
A role for bone morphogenetic protein-4 in adipocyte developmentQ40168350
Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineagesQ41510547
The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis.Q41846475
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonismQ42396920
Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis.Q42831868
Adipocyte size predicts incidence of type 2 diabetes in womenQ47173938
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
morphogenesisQ815547
adipogenesisQ2824461
P1104number of pages8
P304page(s)1217-1224
P577publication date2012-03-23
P1433published inDiabetesQ895262
P1476titleThe WNT inhibitor Dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans
The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans
P478volume61

Reverse relations

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