The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.

scientific article published on 9 January 2018

The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB17-0318
P932PMC publication ID5860863
P698PubMed publication ID29317436

P50authorSami HeikkinenQ47503742
Luke NortonQ51373612
P2093author name stringXi Chen
Marcel Fourcaudot
Nikhil K Acharya
Christopher P Jenkinson
Chris Shannon
Iriscilla Ayala
P2860cites workInhibition of adipogenesis by Wnt signalingQ22254771
Genetic studies of body mass index yield new insights for obesity biologyQ22305005
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalingQ24293496
Regulation of Wnt signaling during adipogenesisQ24299414
Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling moleculesQ24300088
Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5aQ24310811
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisQ24609915
Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific [...]Q28354290
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytesQ28585713
TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liverQ28589957
A novel mechanism for the transcriptional regulation of Wnt signaling in developmentQ28591721
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4Q28592260
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
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Protocol for effective differentiation of 3T3-L1 cells to adipocytesQ30318145
Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source.Q30580914
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studiesQ33337217
Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.Q33553780
Complement factor H is expressed in adipose tissue in association with insulin resistanceQ33556525
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humansQ33738665
Diet-induced adipocyte number increase in adult rats: a new model of obesityQ34274248
Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms.Q34413514
Toward a more complete (and less controversial) understanding of energy expenditure and its role in obesity pathogenesisQ34448641
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Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesityQ35095489
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolismQ35195941
Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansionQ35220578
Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES)Q35242951
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.Q35681058
Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose UptakeQ35885256
The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in HumansQ35902839
TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart StudyQ36199575
Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolismQ36339539
Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections.Q36387190
WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.Q36616934
TCF7L2 and Glucose Metabolism: Time to Look Beyond the PancreasQ36635405
Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite CellsQ36810623
Adipogenesis and WNT signallingQ37325263
Wnt-signalling and the metabolic syndromeQ37392196
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistanceQ37668148
Expression of DGAT2 in white adipose tissue is regulated by central leptin actionQ38334129
Functional interaction between peroxisome proliferator-activated receptor gamma and beta-cateninQ38408437
Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose HomeostasisQ38829763
TLE3 is a dual-function transcriptional coregulator of adipogenesisQ39565699
Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistanceQ39735987
Reduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in MiceQ41949089
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.Q42040756
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewalQ42152874
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetesQ42216029
Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2.Q42292375
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in miceQ42427575
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistanceQ42506602
Analysis of insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytesQ42804549
Wnt4 and Wnt5a promote adipocyte differentiationQ42809469
Effects of TCF7L2 polymorphisms on obesity in European populationsQ42817386
TCF: transcriptional activator or repressor?Q47926649
Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism StudyQ48095500
Chemokines control fat accumulation and leptin secretion by cultured human adipocytesQ57076426
Liver-specific expression of dominant-negative transcription factor 7-like 2 causes progressive impairment in glucose homeostasisQ64377880
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
P1104number of pages15
P304page(s)554-568
P577publication date2018-01-09
P1433published inDiabetesQ895262
P1476titleThe Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function
P478volume67

Reverse relations

cites work (P2860)
Q64914282Assessment of TCF7L2 expression after bariatric surgery.
Q92860432Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM
Q99572135GWA-based pleiotropic analysis identified potential SNPs and genes related to type 2 diabetes and obesity
Q91757730Modelling the gene expression and the DNA-binding in the 3T3-L1 differentiating adipocytes
Q91062894TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes
Q64278096Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
Q90675233Wnt/β-Catenin Signaling and Obesity

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