Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

scientific article

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB12-0239
P932PMC publication ID3478533
P698PubMed publication ID23086040
P5875ResearchGate publication ID232532968

P50authorMarkku LaaksoQ28050161
Pirjo KäkeläQ42169271
Jussi PihlajamäkiQ42169304
Dorota KaminskaQ47201503
P2093author name stringTiina Kuulasmaa
Helena Gylling
Pirjo Käkelä
Sari Venesmaa
Leena Pulkkinen
Maija Vaittinen
Matti Pääkkönen
P2860cites workDecreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionQ24318496
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancerQ24644948
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiationQ28204416
Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targetsQ28506976
Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cellsQ28576997
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesQ29614589
Pre-mRNA splicing and human diseaseQ29617335
Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetesQ33507522
A map of open chromatin in human pancreatic isletsQ33687905
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humansQ33738665
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesisQ35197073
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention ProgramQ35568877
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetesQ35916172
A unique DNA binding domain converts T-cell factors into strong Wnt effectorsQ36315950
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish menQ37163530
Tissue-specific alternative splicing of TCF7L2.Q37357621
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probandsQ37376927
TCF7L2 splice variants have distinct effects on beta-cell turnover and functionQ39584862
C-terminal-binding protein directly activates and represses Wnt transcriptional targets in DrosophilaQ41445240
The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma.Q44471539
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndromeQ45185677
A new beta-catenin-dependent activation domain in T cell factor.Q45943500
Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.Q51795810
Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans.Q54504030
Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual RiskQ57116521
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionQ57278407
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
glycobiologyQ899224
fatty acidQ61476
P304page(s)2807-2813
P577publication date2012-10-18
P1433published inDiabetesQ895262
P1476titleAdipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism
P478volume61

Reverse relations

cites work (P2860)
Q21563356A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
Q47201450Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss
Q36926175Allelic expression imbalance: tipping the scales to elucidate the function of type 2 diabetes-associated loci.
Q64914282Assessment of TCF7L2 expression after bariatric surgery.
Q35131356Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.
Q57298248Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos
Q42292375Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2.
Q37251062Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes
Q34419372Downregulation of type II diabetes mellitus and maturity onset diabetes of young pathways in human pancreatic islets from hyperglycemic donors.
Q52322398Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.
Q37639793Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.
Q51372835Genetics of type 2 diabetes.
Q33882617Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells
Q60044531Palmitate- and C6 ceramide-induced pre-mRNA alternative splicing occurs in a PP2A dependent manner
Q35036444Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146
Q58779722Regulation of Osteoblast Metabolism by Wnt Signaling
Q38132748Regulation of alternative splicing in obesity and weight loss
Q34002255Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition
Q34555421TCF7L2 is a master regulator of insulin production and processing
Q47215931The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.
Q53689686The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance.
Q34712012The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells
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Q90356643Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese
Q50661902Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation.
Q36339601Understanding the elusive mechanism of action of TCF7L2 in metabolism.
Q37702457Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.

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