scholarly article | Q13442814 |
P50 | author | Markku Laakso | Q28050161 |
Pirjo Käkelä | Q42169271 | ||
Jussi Pihlajamäki | Q42169304 | ||
Dorota Kaminska | Q47201503 | ||
P2093 | author name string | Tiina Kuulasmaa | |
Helena Gylling | |||
Pirjo Käkelä | |||
Sari Venesmaa | |||
Leena Pulkkinen | |||
Maija Vaittinen | |||
Matti Pääkkönen | |||
P2860 | cites work | Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function | Q24318496 |
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer | Q24644948 | ||
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation | Q28204416 | ||
Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets | Q28506976 | ||
Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells | Q28576997 | ||
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes | Q29614589 | ||
Pre-mRNA splicing and human disease | Q29617335 | ||
Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes | Q33507522 | ||
A map of open chromatin in human pancreatic islets | Q33687905 | ||
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans | Q33738665 | ||
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis | Q35197073 | ||
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program | Q35568877 | ||
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes | Q35916172 | ||
A unique DNA binding domain converts T-cell factors into strong Wnt effectors | Q36315950 | ||
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men | Q37163530 | ||
Tissue-specific alternative splicing of TCF7L2. | Q37357621 | ||
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands | Q37376927 | ||
TCF7L2 splice variants have distinct effects on beta-cell turnover and function | Q39584862 | ||
C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila | Q41445240 | ||
The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. | Q44471539 | ||
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome | Q45185677 | ||
A new beta-catenin-dependent activation domain in T cell factor. | Q45943500 | ||
Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. | Q51795810 | ||
Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans. | Q54504030 | ||
Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk | Q57116521 | ||
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution | Q57278407 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported | Q19125045 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 11 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | glucose | Q37525 |
glycobiology | Q899224 | ||
fatty acid | Q61476 | ||
P304 | page(s) | 2807-2813 | |
P577 | publication date | 2012-10-18 | |
P1433 | published in | Diabetes | Q895262 |
P1476 | title | Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism | |
P478 | volume | 61 |
Q21563356 | A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue |
Q47201450 | Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss |
Q36926175 | Allelic expression imbalance: tipping the scales to elucidate the function of type 2 diabetes-associated loci. |
Q64914282 | Assessment of TCF7L2 expression after bariatric surgery. |
Q35131356 | Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2. |
Q57298248 | Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos |
Q42292375 | Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2. |
Q37251062 | Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes |
Q34419372 | Downregulation of type II diabetes mellitus and maturity onset diabetes of young pathways in human pancreatic islets from hyperglycemic donors. |
Q52322398 | Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits. |
Q37639793 | Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. |
Q51372835 | Genetics of type 2 diabetes. |
Q33882617 | Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells |
Q60044531 | Palmitate- and C6 ceramide-induced pre-mRNA alternative splicing occurs in a PP2A dependent manner |
Q35036444 | Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146 |
Q58779722 | Regulation of Osteoblast Metabolism by Wnt Signaling |
Q38132748 | Regulation of alternative splicing in obesity and weight loss |
Q34002255 | Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition |
Q34555421 | TCF7L2 is a master regulator of insulin production and processing |
Q47215931 | The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function. |
Q53689686 | The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance. |
Q34712012 | The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells |
Q38751178 | The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5. |
Q90356643 | Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese |
Q50661902 | Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation. |
Q36339601 | Understanding the elusive mechanism of action of TCF7L2 in metabolism. |
Q37702457 | Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. |
Search more.