Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation

scientific article published on 07 April 2009

Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB08-1770
P932PMC publication ID2699851
P698PubMed publication ID19351711
P5875ResearchGate publication ID24262653

P2093author name stringAnn Hammarstedt
Ulf Smith
Birgit Gustafson
Petter Isakson
P2860cites workSubcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesityQ51032064
Relation of body fat distribution to metabolic complications of obesityQ51652119
In vitro differentiation of mesenchymal progenitor cells derived from porcine umbilical cord blood.Q53506426
A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjectsQ53847918
Large-scale isolation of CD133+ progenitor cells from G-CSF mobilized peripheral blood stem cells.Q54785700
Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophyQ58642121
Committed subcutaneous preadipocytes are reduced in human obesityQ79345667
Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytesQ80010792
Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytesQ24304097
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Inflammation and metabolic disordersQ27860923
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker ratsQ28379378
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factorQ29547912
Dynamics of fat cell turnover in humansQ29615688
TLR4 links innate immunity and fatty acid-induced insulin resistanceQ29617577
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humansQ29622900
Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distributionQ33822416
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesQ33918445
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transportQ34478969
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in miceQ35970899
Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?Q36773597
Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosisQ36933062
Fat cell distribution and metabolismQ39661396
Effects of age, sex, and clinical conditions on adipose tissue cellularity in manQ39946915
Preadipocyte conversion to macrophage. Evidence of plasticity.Q40678700
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid1Q41722978
Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.Q42027895
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjectsQ42797512
Distinct transcriptional profiles of adipogenesis in vivo and in vitroQ42827325
Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesionQ42827506
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.Q42828385
Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and resistinQ42829111
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humansQ44730563
Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazoneQ46620643
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
inflammationQ101991
P304page(s)1550-1557
P577publication date2009-04-07
P1433published inDiabetesQ895262
P1476titleImpaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation
P478volume58

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