Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

scientific article published on 21 June 2019

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2019NatCo..10.2757G
P356DOI10.1038/S41467-019-10688-X
P932PMC publication ID6588633
P698PubMed publication ID31227697

P50authorUlf SmithQ56809371
P2093author name stringBirgit Gustafson
Annika Nerstedt
P2860cites workFunctional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?Q38368484
ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.Q38700338
Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipidsQ38809397
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and FrailtyQ39032248
Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of SenescenceQ39344951
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.Q40476668
The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissueQ42649980
Unmasking Transcriptional Heterogeneity in Senescent CellsQ42777490
DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of AdipocytesQ42809189
Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes.Q47344563
BMP4 and BMP Antagonists Regulate Human White and Beige AdipogenesisQ47757011
Insulin action and age. European Group for the Study of Insulin Resistance (EGIR).Q51028523
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body compositionQ53697033
A crucial role for adipose tissue p53 in the regulation of insulin resistanceQ84491291
Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?Q87415819
Senolytics improve physical function and increase lifespan in old ageQ89486364
Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic ObesityQ90685537
Targeting senescent cells alleviates obesity-induced metabolic dysfunctionQ92589039
Cellular senescence in aging and age-related disease: from mechanisms to therapyQ26773500
Pathophysiology of Human Visceral Obesity: An UpdateQ26864356
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersQ28252088
Dynamics of fat cell turnover in humansQ29615688
Adipocyte turnover: relevance to human adipose tissue morphologyQ33556451
Transcriptional control of preadipocyte determination by Zfp423.Q33753951
Cellular senescence drives age-dependent hepatic steatosis.Q33810220
Genetic Predisposition for Type 2 Diabetes, but Not for Overweight/Obesity, Is Associated with a Restricted AdipogenesisQ33885827
Adipose-derived mesenchymal stromal/stem cells: An update on their phenotype in vivo and in vitroQ34038832
Cellular senescence: from physiology to pathologyQ34041305
Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switchQ34056522
Regulation of early adipose commitment by Zfp521.Q34499279
Targeting senescent cells enhances adipogenesis and metabolic function in old ageQ34505890
Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene.Q35016478
Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemiaQ35849887
WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.Q36616934
Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4Q37110526
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammationQ37236239
Imaging mass spectrometry demonstrates age-related decline in human adipose plasticityQ37677435
Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the InternatioQ37691742
P433issue1
P921main subjectadipogenesisQ2824461
P304page(s)2757
P577publication date2019-06-21
P1433published inNature CommunicationsQ573880
P1476titleReduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
P478volume10

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cites work (P2860)
Q96609566Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese men
Q104479851Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
Q98226258Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation
Q94522061Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes
Q98611605Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men
Q90393831Role of p53 in the Regulation of Cellular Senescence
Q101564351Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver
Q90246578The role of cellular senescence in ageing and endocrine disease

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