Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance

scientific article published on 24 June 2016

Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00125-016-4031-3
P932PMC publication ID5506102
P698PubMed publication ID27342408

P50authorMohamed A ElrayessQ59566964
Morana JaganjacQ41876125
P2093author name stringNayef A Mazloum
Vidya Mohamed-Ali
Mohammed Alsayrafi
Moataz Bashah
Fatima Al-Khelaifi
Ilhame Diboun
Houari Abdesselem
Wael Kafienah
Shamma Almuraikhy
P2860cites workAdipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescenceQ24626078
Mechanisms and Metabolic Implications of Regional Differences among Fat DepotsQ27004113
Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrowQ28281346
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker ratsQ28379378
Increased oxidative stress in obesity and its impact on metabolic syndromeQ29012150
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factorQ29547912
Dynamics of fat cell turnover in humansQ29615688
Adipocyte differentiation from the inside outQ29615690
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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humansQ29622900
Interleukin-6 represses the transcription of the CCAAT/enhancer binding protein-alpha gene in hepatoma cells by inhibiting its ability to autoactivate the proximal promoter regionQ33195176
Adipocyte turnover: relevance to human adipose tissue morphologyQ33556451
Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiationQ33694864
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesQ33918445
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The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesityQ34271384
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophilsQ62658841
Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesisQ62658906
Relationship between degree of obesity and in vivo insulin action in manQ69885304
Surface protein characterization of human adipose tissue-derived stromal cellsQ74559072
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depotsQ80596917
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1Q34449273
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A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes.Q35061663
Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fatQ35130591
Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4Q37110526
Plasma triglyceride/HDL-cholesterol ratio, insulin resistance, and cardiometabolic risk in young adultsQ37163053
RANTES release by human adipose tissue in vivo and evidence for depot-specific differencesQ37216728
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammationQ37236239
Inflammation and impaired adipogenesis in hypertrophic obesity in man.Q37557999
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Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?Q37979422
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Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistanceQ41299746
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscleQ42135596
Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes.Q42439066
Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte functionQ42504083
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjectsQ42797512
Pref-1, a preadipocyte secreted factor that inhibits adipogenesisQ42833486
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone.Q42834547
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitroQ43982432
Chronic exposure to interleukin-6 causes hepatic insulin resistance in miceQ44631827
Differentiation of adipose stem cellsQ45878079
The metabolically healthy but obese individual presents a favorable inflammation profileQ46458620
Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes.Q47344563
Adipose tissue and metabolic alterations: regional differences in fat cell size and number matter, but differently: a cross-sectional studyQ47580330
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P921main subjectobesityQ12174
insulin resistanceQ1053470
adipogenesisQ2824461
P304page(s)2406-2416
P577publication date2016-06-24
P1433published inDiabetologiaQ5270140
P1476titleInterleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance
P478volume59

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