Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

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Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases is …
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scholarly articleQ13442814

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P819ADS bibcode1997PNAS...94.1680F
P356DOI10.1073/PNAS.94.5.1680
P8608Fatcat IDrelease_ry6iba57fratvn7keglks6p3lm
P3181OpenCitations bibliographic resource ID3204783
P932PMC publication ID19976
P698PubMed publication ID9050838
P5875ResearchGate publication ID14160297

P50authorTony TiganisQ37382684
P2093author name stringN K Tonks
A J Flint
D Barford
P2860cites workThe nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequenceQ24301399
Substrate specificity of the protein tyrosine phosphatasesQ24309619
Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1BQ24311668
COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleusQ24316086
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1BQ24557671
Cloning of a cDNA for a major human protein-tyrosine-phosphataseQ24558722
A catalytic mechanism for the dual-specific phosphatasesQ24563405
Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.Q24647903
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1BQ27729426
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstateQ27730850
Crystal structure of human protein tyrosine phosphatase 1BQ27731235
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860608
Cloning and expression of a protein-tyrosine-phosphataseQ28577079
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivoQ29615244
Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblastsQ30442281
Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylationQ34050342
From form to function: signaling by protein tyrosine phosphatases.Q34405391
Purification of the major protein-tyrosine-phosphatases of human placentaQ34554142
Characterization of the major protein-tyrosine-phosphatases of human placenta.Q34554150
Dissecting the catalytic mechanism of protein-tyrosine phosphatasesQ35063279
Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chainQ35886042
The Yersinia tyrosine phosphatase: specificity of a bacterial virulence determinant for phosphoproteins in the J774A.1 macrophageQ36232127
Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysisQ36799816
The Cys(X)5Arg catalytic motif in phosphoester hydrolysisQ38301012
Protein tyrosine phosphatases take off.Q41143264
Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.Q45949013
Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signalingQ46765571
Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediateQ50335611
Protein tyrosine phosphatases and the control of cellular signaling responsesQ71475516
Purification and crystallization of the catalytic domain of human protein tyrosine phosphatase 1B expressed in Escherichia coliQ72023400
Acidic residues are involved in substrate recognition by two soluble protein tyrosine phosphatases, PTP-5 and rrbPTP-1Q72609567
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1680-5
P577publication date1997-03-04
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDevelopment of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases
P478volume94

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Q26996773Mining the function of protein tyrosine phosphatases in health and disease
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Q34213559Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation
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Q35382936Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma
Q40653756Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking
Q40852967Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway
Q22254632Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
Q42952088N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth
Q24321559Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP
Q34281830Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.
Q42656002Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B.
Q35916532Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury
Q43939997Neu-mediated phosphorylation of protein tyrosine phosphatase epsilon is critical for activation of Src in mammary tumor cells
Q37377130New functional aspects of the atypical protein tyrosine phosphatase VHZ.
Q38903183New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA: hints of a bacterial modulation of macrophage bioenergetics state.
Q34047274Nuclear tyrosine phosphorylation: the beginning of a map.
Q37233426Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl
Q24322705P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Q41849340PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells
Q22011205PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta
Q37807363PRL‐3 phosphatase and cancer metastasis
Q28287950PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase
Q28217868PTEN associates with the vault particles in HeLa cells
Q40404987PTEN functions by recruitment to cytoplasmic vesicles
Q43104730PTEN: sometimes taking it off can be better than putting it on.
Q24317102PTP-1B is an essential positive regulator of platelet integrin signaling
Q27312034PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.
Q33557675PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity
Q36602604PTP1B and TC-PTP: novel roles in immune-cell signaling
Q37992232PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
Q37074418PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
Q43135410PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis
Q36040491PTP1B inhibition suggests a therapeutic strategy for Rett syndrome
Q36969867PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
Q24313351PTP1B regulates Eph receptor function and trafficking
Q24294879PTP1B regulates leptin signal transduction in vivo
Q37728307PTP1B: a double agent in metabolism and oncogenesis
Q34209253PTP1B: from the sidelines to the front lines!
Q24606638PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction
Q31032344PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit
Q35094072PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase
Q37081432PTPL1: a large phosphatase with a split personality
Q90132188PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response
Q92578183PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization
Q41828282Paladin is an antiphosphatase that regulates neural crest cell formation and migration
Q38892813Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.
Q38285175Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies
Q48013149Phosphatases and kinases in lymphocyte signaling
Q24295196Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration
Q28180428Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon
Q28589506Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor
Q34263558Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors
Q51836870Photogenerated quinone methides as protein affinity labeling reagents.
Q37611336Physiological signaling specificity by protein tyrosine phosphatases
Q44283243Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif
Q24298615Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
Q30325800Prediction of a ligand-induced conformational change in the catalytic core of Cdc25A.
Q33194214Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library
Q44112967Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition
Q46935318Prolonged EGFR signaling by ERBB2-mediated sequestration at the plasma membrane
Q34805653Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice
Q38200472Protein phosphatases in pancreatic islets.
Q43115433Protein phosphorylation and protein phosphatases. De Panne, Belgium, September 19-24, 1999.
Q39228225Protein tyrosine phosphatase 1B (PTP1B) modulates palmitate-induced cytokine production in macrophage cells
Q24311296Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo
Q35002509Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling
Q27305216Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes
Q36437015Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies
Q24296932Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling
Q36928998Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation
Q37969987Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases
Q24290951Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation
Q41879189Protein tyrosine phosphatase PTP1B in cell adhesion and migration
Q36729655Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells
Q35146110Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation
Q44774251Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells
Q37387988Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src.
Q36713273Protein tyrosine phosphatase function: the substrate perspective
Q40442779Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization
Q36489196Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells.
Q24304888Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells
Q34023798Protein tyrosine phosphatase-1B in diabetes
Q36798438Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina
Q34419522Protein tyrosine phosphatases in signal transduction.
Q33565458Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation
Q24622527Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction
Q77946535Protein tyrosine phosphatases: counting the trees in the forest
Q29614826Protein tyrosine phosphatases: from genes, to function, to disease
Q53852755Protein tyrosine phosphatases: their role in insulin action and potential as drug targets.
Q35185678Protein tyrosyl phosphatases in T cell activation: implication for human immunodeficiency virus transcriptional activity
Q34509577Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling
Q37112768Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells
Q46761334Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure
Q24295233Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors
Q35118726Protein-tyrosine phosphatase 1B substrates and metabolic regulation
Q39603499Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling
Q46962386Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth
Q38362451Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells
Q33832583Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells
Q40033133Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling
Q48021656Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
Q36430193Protein-tyrosine phosphatases and cancer
Q41739061Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis
Q35074889Proteomics: the first decade and beyond
Q34381500Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases
Q51090377Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response.
Q28468277Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells
Q38252989R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development
Q24300000Reactivation of oxidized PTP1B and PTEN by thioredoxin 1
Q33630136Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation
Q24675717Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia
Q24312704Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration
Q33761927Receptor protein tyrosine phosphatases are novel components of a polycystin complex
Q36731957Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body
Q34963286Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function
Q53045957Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation.
Q24293413Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function
Q27695708Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation
Q27664961Recognition of Nucleoside Monophosphate Substrates by Haemophilus influenzae Class C Acid Phosphatase
Q36476273Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation
Q37073431Redox regulation of interleukin-4 signaling
Q35174581Redox regulation of protein kinases
Q27641430Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
Q33800728Redox regulation of signal transduction in mammalian cells
Q39802746Regulation and function of protein kinases and phosphatases
Q36588906Regulation and functional relevance of milk fat globules and their components in the mammary gland
Q41607150Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.
Q24653458Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
Q36741267Regulation of ROS signal transduction by NADPH oxidase 4 localization
Q45923768Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling.
Q33815738Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B
Q28298939Regulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesion
Q53777253Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.
Q28511379Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes
Q28295462Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST
Q35108594Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
Q24296501Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP
Q44932599Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.
Q24292424Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts
Q42788780Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).
Q24299014Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase
Q91756829Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2
Q40672244Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols
Q34288873Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.
Q24316395Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase
Q42565548Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B
Q42665532Relation between the flexibility of the WPD loop and the activity of the catalytic domain of protein tyrosine phosphatase SHP-1.
Q41465181Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis.
Q22253482Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha
Q41650140Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase
Q29615579Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
Q33996724Role of JNK in network formation of human lung microvascular endothelial cells
Q41514648Role of phosphatases in lymphocyte activation.
Q33796479Role of protein phosphatases in the regulation of human mast cell and basophil function
Q42199994Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells
Q43817828Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells
Q33834442Roles of protein tyrosine phosphatases in cell migration and adhesion
Q74129083SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase
Q40550696SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway
Q24292512SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription
Q28284908SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors
Q89722310SUMO Protease SMT7 Modulates Ribosomal Protein L30 and Regulates Cell-size Checkpoint Function
Q33924999SUMOylation of Psmd1 controls Adrm1 interaction with the proteasome
Q24294324Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
Q36301565Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.
Q29617413Signaling--2000 and beyond
Q36047190Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography.
Q36426218Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1.
Q92607280Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4
Q34768047Specificity profiling of protein phosphatases toward phosphoseryl and phosphothreonyl peptides
Q27936648Ssu72 Is an RNA polymerase II CTD phosphatase
Q50891541Steered Molecular Dynamics for Investigating the Interactions Between Insulin Receptor Tyrosine Kinase (IRK) and Variants of Protein Tyrosine Phosphatase 1B (PTP1B).
Q28546701Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1
Q52655508Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates.
Q34012560Structural and evolutionary relationships among protein tyrosine phosphatase domains
Q39631199Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction
Q27631738Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme
Q27638439Structure determination of T cell protein-tyrosine phosphatase
Q35071031Structure-function analyses of tyrosine phosphatase PTP69D in giant fiber synapse formation of Drosophila
Q39660456Studying the Regulation of MAP Kinase by MAP Kinase Phosphatases In Vitro and in Cell Systems
Q27315888Subcellular Partitioning of Protein Tyrosine Phosphatase 1B to the Endoplasmic Reticulum and Mitochondria Depends Sensitively on the Composition of Its Tail Anchor
Q37095466Substrate specificity of R3 receptor-like protein-tyrosine phosphatase subfamily toward receptor protein-tyrosine kinases
Q24309015Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
Q33811181Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.
Q34060655Sumo-dependent substrate targeting of the SUMO protease Ulp1
Q47608480Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase
Q41485755Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases
Q30541159Synaptic plasticity: one STEP at a time
Q24297041T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
Q28590621T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation
Q35806647T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts
Q34005525TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
Q24291860TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
Q51577103Tailor-Made Protein Tyrosine Phosphatases: In Vitro Site-Directed Mutagenesis of PTEN and PTPRZ-B.
Q33554884Targeting PTPs with small molecule inhibitors in cancer treatment
Q45292159Teaching resources. Protein phosphatases
Q41008340The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.
Q48207784The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy.
Q39117221The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling.
Q28145888The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP
Q35770577The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice
Q52937486The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites.
Q58377593The Role of TCPTP in Cancer
Q24306901The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities
Q43074065The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche
Q24292506The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3
Q27661333The Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46
Q43607722The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase
Q40826483The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages
Q27931733The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression
Q36403213The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation
Q34308157The application of modular protein domains in proteomics
Q43862884The catalytic mechanism of Cdc25A phosphatase
Q37233379The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F.
Q24620636The chemical biology of protein phosphorylation
Q64101666The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion
Q24682886The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage
Q37405181The phosphatase SHP2 regulates the spacing effect for long-term memory induction
Q37630230The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity
Q28507911The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions
Q24679774The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin
Q40784926The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.
Q28144437The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling
Q30009978The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1
Q30156949The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation
Q31157967The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1
Q96765569The receptor PTPRU is a redox sensitive pseudophosphatase
Q37428899The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism.
Q24299978The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1
Q24622106The role of protein tyrosine phosphatase 1B in Ras signaling
Q24301273The role of protein-tyrosine phosphatase 1B in integrin signaling
Q77631111The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-zeta in vivo
Q30498983The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala
Q27633455The structure of apo protein-tyrosine phosphatase 1B C215S mutant: More than just an S → O change
Q28141335The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells
Q24310022The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)
Q24307844The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking
Q34654408The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling
Q52540578Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.
Q40023975Transmembrane glycoprotein gp150 is a substrate for receptor tyrosine phosphatase DPTP10D in Drosophila cells
Q34365568Trypanosomatid protein phosphatases
Q27315422Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling
Q36308947Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells
Q40623571Tyrosine phosphatase PTP1B modulates store-operated calcium influx.
Q28247569Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4
Q44323339Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells
Q35128273Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells
Q38953607Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation
Q24676902Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro
Q40816324Tyrosine-phosphorylated caveolin is a physiological substrate of the low M(r) protein-tyrosine phosphatase
Q30663794Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode
Q51577059Use of Dominant-Negative/Substrate Trapping PTP Mutations to Search for PTP Interactors/Substrates.
Q30539522VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
Q35661770Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
Q30159671Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface
Q27749490Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography
Q28086901Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research
Q34026657Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
Q88754820miCLIP-MaPseq, a Substrate Identification Approach for Radical SAM RNA Methylating Enzymes
Q35604861γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.