Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode

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Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode is …
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scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.8047S
P6179Dimensions Publication ID1001947143
P356DOI10.1038/NCOMMS9047
P932PMC publication ID4560775
P698PubMed publication ID26292967
P5875ResearchGate publication ID281139680

P2093author name stringOla Sabet
Georgia Xouri
Philippe I H Bastiaens
Yannick Brüggemann
Angel Stanoev
Rabea Stockert
P2860cites workThreshold-controlled ubiquitination of the EGFR directs receptor fateQ24296784
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathwayQ24301313
Identification of the switch in early-to-late endosome transitionQ24309112
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with AktQ24310260
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targetsQ24313085
Conformational coupling across the plasma membrane in activation of the EGF receptorQ24313122
PTP1B regulates Eph receptor function and traffickingQ24313351
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatasesQ24323070
Cell signaling by receptor tyrosine kinasesQ24598357
Rab11 regulates recycling through the pericentriolar recycling endosomeQ24681897
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinaseQ27617539
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane regionQ27635000
Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3)Q27650800
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assemblyQ27660230
Architecture of Eph receptor clustersQ27661948
Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsQ27679152
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptorsQ28207179
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-MetQ28207199
Eph/ephrin signalling during developmentQ28277802
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinasesQ28590498
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptorsQ28647596
Eph-ephrin bidirectional signaling in physiology and diseaseQ29617975
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomesQ29619337
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathwayQ29620272
A photoactivatable GFP for selective photolabeling of proteins and cellsQ29620329
Eph receptors and ephrins in cancer: bidirectional signalling and beyondQ34021365
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.Q34158339
Imaging biochemistry inside cellsQ34228151
Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.Q34288873
Lateral phosphorylation propagation: an aspect of feedback signalling?Q35613400
Redox regulation of protein-tyrosine phosphatasesQ35998127
Identification of two lysosomal membrane glycoproteinsQ36212360
Recruitment of Eph receptors into signaling clusters does not require ephrin contactQ36322098
Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5aQ36342565
Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assayQ36388189
Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymesQ36408150
Repulsion or adhesion: receptors make the callQ36576257
Endocytosis of receptor tyrosine kinasesQ36783457
Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathwayQ36993347
Eph, a protein family coming of age: more confusion, insight, or complexity?Q37138899
Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestrationQ37169470
EphA2 signaling following endocytosis: role of Tiam1.Q37385339
The composition of EphB2 clusters determines the strength in the cellular repulsion response.Q37550642
The endocytic matrixQ37683362
Signaling from the living plasma membraneQ37854177
Eph-dependent cell-cell adhesion and segregation in development and cancer.Q37971902
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cellsQ39656465
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.Q39995504
Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.Q40186431
Red-edge anisotropy microscopy enables dynamic imaging of homo-FRET between green fluorescent proteins in cellsQ40562831
Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cellsQ40641471
Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption.Q40670984
Negative regulation of EphA2 receptor by Cbl.Q40714708
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathwayQ40808897
A Continuous Spectrophotometric and Fluorometric Assay for Protein Tyrosine Phosphatase Using Phosphotyrosine-Containing PeptidesQ41503236
Lateral propagation of EGF signaling after local stimulation is dependent on receptor density.Q42525174
Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O.Q42802380
Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interactionQ43179203
EphA2 overexpression causes tumorigenesis of mammary epithelial cells.Q43561178
Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulumQ43901714
Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulationQ44026940
c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.Q44259057
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagationQ44419417
Precise measurement of protein interacting fractions with fluorescence lifetime imaging microscopyQ45360459
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadateQ71973575
E-cadherin regulates the function of the EphA2 receptor tyrosine kinaseQ73053220
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)8047
P577publication date2015-08-21
P1433published inNature CommunicationsQ573880
P1476titleUbiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode
P478volume6

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cites work (P2860)
Q58705164A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
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Q38816457EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling
Q37350976EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells
Q49384083Emerging roles of extracellular vesicles in cellular senescence and aging
Q46756335EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens
Q54980075EphA2 transmembrane domain is uniquely required for keratinocyte migration by regulating ephrin-A1 levels.
Q41059776Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance
Q92709824Ephrin-A5 potentiates netrin-1 axon guidance by enhancing Neogenin availability
Q37063781Exosomes expand the sphere of influence of Eph receptors and ephrins
Q91932843Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
Q89896370Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions
Q30842168Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
Q33745433Reversible Cryo-arrests of Living Cells to Pause Molecular Movements for High-resolution Imaging
Q28828817Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution
Q41543057SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.
Q26766002Signal processing by the endosomal system
Q42208698Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
Q48228631The EGFR odyssey - from activation to destruction in space and time.
Q57147941The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures
Q92668882The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance

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