| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Andrew P Cope | Q61091985 |
| P2093 | author name string | Lena Svensson | |
| Manoj Saini | |||
| Garth L Burn | |||
| Cristina Sanchez-Blanco | |||
| P2860 | cites work | Subcellular localization of intracellular protein tyrosine phosphatases in T cells | Q24273420 |
| The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation | Q24292410 | ||
| Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases | Q24302097 | ||
| Identification of substrates of human protein-tyrosine phosphatase PTPN22 | Q24303819 | ||
| Identification of a variant form of tyrosine phosphatase LYP | Q24305267 | ||
| The tyrosine kinase Csk dimerizes through Its SH3 domain | Q24314372 | ||
| PTPN22 gene regulates natural killer cell proliferation during in vitro expansion | Q24316976 | ||
| Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant | Q24317388 | ||
| Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling | Q24318432 | ||
| Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases | Q24323070 | ||
| Positive and negative regulation of T-cell activation through kinases and phosphatases | Q24535649 | ||
| Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4 | Q24538382 | ||
| Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue | Q24630403 | ||
| T cell activation | Q24658051 | ||
| PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase | Q24679587 | ||
| Crystal Structure of the Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights into Redox Regulation, | Q27654834 | ||
| Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes | Q28237016 | ||
| Recent advances in the genetics of autoimmune disease | Q28238782 | ||
| Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population | Q28248685 | ||
| A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes | Q28248848 | ||
| A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis | Q28267921 | ||
| Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk) | Q28270491 | ||
| Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. | Q28273794 | ||
| HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity? | Q28277382 | ||
| Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant | Q28280659 | ||
| Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model | Q28283437 | ||
| Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus | Q28289699 | ||
| Protein tyrosine phosphatases and the immune response | Q28300971 | ||
| Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus | Q28301821 | ||
| PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells | Q28590230 | ||
| Protein tyrosine phosphatases: from genes, to function, to disease | Q29614826 | ||
| Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population | Q46831303 | ||
| Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population. | Q46883159 | ||
| Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis. | Q46912103 | ||
| The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population. | Q51807268 | ||
| No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | Q51932778 | ||
| Tempo and mode in the endocannaboinoid system. | Q52840210 | ||
| Genetic Influence of PTPN22 R620W Polymorphism in Tuberculosis | Q56452948 | ||
| Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection | Q57307108 | ||
| PTPN22 and invasive bacterial disease | Q57763988 | ||
| Replication validity of genetic association studies | Q29615456 | ||
| A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling. | Q30157747 | ||
| Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase | Q30175917 | ||
| The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. | Q32170429 | ||
| Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. | Q33942125 | ||
| Constitutively active Lck kinase in T cells drives antigen receptor signal transduction | Q34376930 | ||
| Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease | Q34556560 | ||
| Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins | Q34612482 | ||
| Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain | Q35041312 | ||
| Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. | Q35184781 | ||
| Protein tyrosine phosphatases in T cell physiology. | Q35818873 | ||
| Pathogenic autoantibodies in lupus nephritis | Q36054822 | ||
| The tipping points in the initiation of B cell signalling: how small changes make big differences. | Q36121790 | ||
| The Vav family: at the crossroads of signaling pathways | Q36232743 | ||
| PTPN22: setting thresholds for autoimmunity | Q36491114 | ||
| A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus | Q37292827 | ||
| PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. | Q37396708 | ||
| Natural killer cells in human autoimmunity | Q37628235 | ||
| Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population | Q39158993 | ||
| Molecular basis of the motheaten phenotype | Q40694874 | ||
| The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population | Q42164342 | ||
| Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70 | Q42481636 | ||
| Deep resequencing reveals excess rare recent variants consistent with explosive population growth | Q42700588 | ||
| Csk-mediated phosphorylation of substrates is regulated by substrate tyrosine phosphorylation | Q42828442 | ||
| Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice | Q42942030 | ||
| PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection | Q42984199 | ||
| Localization of PTP-FERM in nerve processes through its FERM domain | Q43915251 | ||
| PTPN22 C1858T polymorphism and human brucellosis. | Q44549601 | ||
| Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck. | Q44881978 | ||
| The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease | Q45142894 | ||
| An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity | Q46113259 | ||
| The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update | Q46200110 | ||
| Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases | Q46368513 | ||
| Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population | Q46396187 | ||
| No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome | Q46525705 | ||
| Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene | Q46525978 | ||
| Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset | Q46534885 | ||
| PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis | Q46557023 | ||
| Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort | Q46573581 | ||
| A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo | Q46599062 | ||
| Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort. | Q46689842 | ||
| PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases | Q46703705 | ||
| Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease | Q46732649 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 3689-3698 | |
| P577 | publication date | 2011-04-20 | |
| P1433 | published in | FEBS Letters | Q1388051 |
| P1476 | title | Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? | |
| P478 | volume | 585 |
| Q64075676 | 'RA and the microbiome: do host genetic factors provide the link? |
| Q27678355 | A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases |
| Q33591011 | A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis |
| Q34380329 | Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis |
| Q33924642 | Altered B cell signalling in autoimmunity |
| Q39643697 | Association Between PTPN22 Polymorphisms and IgE Responses to Staphylococcal Superantigens in Chronic Urticaria |
| Q54336569 | Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families. |
| Q36335826 | Association between PTPN22 C1858T polymorphism and alopecia areata risk |
| Q28597963 | Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden |
| Q89792592 | Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo |
| Q46840442 | Association of PTPN22 1858C→T polymorphism, HLA-DRB1 shared epitope and autoantibodies with rheumatoid arthritis. |
| Q90219465 | Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils |
| Q37479048 | Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
| Q51046617 | Association of STAT4 rs7574865 and PTPN22 rs2476601 polymorphisms with rheumatoid arthritis and non-systemically reacting antibodies in Egyptian patients. |
| Q37033053 | Autoimmune Variant PTPN22 C1858T Is Associated With Impaired Responses to Influenza Vaccination |
| Q99711793 | Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective? |
| Q38030480 | Autologous regulatory T cells for the treatment of type 1 diabetes |
| Q64262983 | B Cells as a Therapeutic Target in Paediatric Rheumatic Disease |
| Q34982012 | Biomarkers predicting a need for intensive treatment in patients with early arthritis |
| Q39022002 | C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes? |
| Q38127357 | Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes. |
| Q33837769 | Coherent somatic mutation in autoimmune disease |
| Q48004863 | Coincidence of PTPN22 c.1858CC and FCRL3 -169CC genotypes as a biomarker of preserved residual β-cell function in children with type 1 diabetes. |
| Q38909947 | Construction of a Comprehensive Protein-Protein Interaction Map for Vitiligo Disease to Identify Key Regulatory Elements: A Systemic Approach |
| Q54161634 | Distribution of PTPN22 polymorphisms in SLE from western Mexico: correlation with mRNA expression and disease activity. |
| Q26741457 | Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents |
| Q35857726 | Effect of the PTPN22 and INS risk genotypes on the progression to clinical type 1 diabetes after the initiation of β-cell autoimmunity |
| Q91864017 | Epigenetic influences on genetically triggered thoracic aortic aneurysm |
| Q26770562 | Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease |
| Q41026453 | Genetic link of type 1 diabetes susceptibility loci with rheumatoid arthritis in Pakistani patients. |
| Q34288248 | Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus |
| Q35921093 | Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis |
| Q37958780 | Genetics of systemic sclerosis: an update |
| Q34278457 | Hashimoto's Thyroiditis: From Genes to the Disease |
| Q33594416 | Hypothyroidism among pediatric patients with type 1 diabetes mellitus, from patients' characteristics to disease severity |
| Q48522341 | Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort |
| Q38034937 | Influence of type 1 diabetes genes on disease progression: similarities and differences between countries |
| Q34967191 | Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery. |
| Q26827065 | Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics |
| Q36437284 | Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases |
| Q39207486 | Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling |
| Q34187065 | No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations |
| Q52660643 | Novel insights into the aetiology of granulomatosis with polyangiitis-a case-control study using the Clinical Practice Research Datalink. |
| Q47839399 | PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update |
| Q89666188 | PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion |
| Q51604912 | PTPN22 C1858T and the risk of psoriasis: a meta-analysis. |
| Q92701665 | PTPN22 Gene Polymorphisms Are Associated with Susceptibility to Large Artery Atherosclerotic Stroke and Microembolic Signals |
| Q34946314 | PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes |
| Q42075872 | PTPN22 in autoimmunity: different cell and different way. |
| Q35221741 | PTPN22: the archetypal non-HLA autoimmunity gene |
| Q90479784 | Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses |
| Q42064816 | Protein tyrosine phosphatase PTPN22 +1858C/T polymorphism is associated with active vitiligo |
| Q42685362 | Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells. |
| Q47742898 | Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice. |
| Q57961646 | Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses |
| Q38003542 | Protein tyrosine phosphatases in lymphocyte activation and autoimmunity |
| Q41953614 | Recent advances in genetic predisposition of myasthenia gravis |
| Q38006992 | Review of the risks and benefits of yellow fever vaccination including some new analyses |
| Q27005625 | Risk factors and primary prevention trials for type 1 diabetes |
| Q46154464 | Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype |
| Q34259510 | Road to fulfilment: taming the immune response to restore vision |
| Q58716481 | Robust Innate Immunity of Young Rabbits Mediates Resistance to Rabbit Hemorrhagic Disease Caused by Lagovirus Europaeus GI.1 But Not GI.2 |
| Q38904874 | Role of the C1858T polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in children and adolescents with type 1 diabetes |
| Q35186565 | STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients |
| Q39323124 | Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity. |
| Q34888501 | Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms. |
| Q37993692 | T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. |
| Q89860622 | The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review |
| Q58544776 | The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease |
| Q38788500 | The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population. |
| Q34399280 | The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis |
| Q64987239 | The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies. |
| Q45301092 | The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals |
| Q40867605 | The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico |
| Q60651239 | The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization |
| Q58714558 | The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens |
| Q84372521 | The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis |
| Q28080019 | The thymus and rheumatology: should we care? |
| Q38858288 | Thymic Germinal Centers and Corticosteroids in Myasthenia Gravis: an Immunopathological Study in 1035 Cases and a Critical Review |
| Q35309080 | Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22. |
| Q38543383 | Understanding the major risk factors in the beginning and the progression of rheumatoid arthritis: current scenario and future prospects |
| Q84027456 | [Psoriasis and inflammatory bowel diseases] |
| Q37657125 | rs2476601 polymorphism in PTPN22 is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls |
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