Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4

scientific article

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1086/498651
P3181OpenCitations bibliographic resource ID1831211
P932PMC publication ID1285162
P698PubMed publication ID16380915
P5875ResearchGate publication ID7390312

P50authorDavid AltshulerQ5230746
Lars KlareskogQ5912759
Peter K. GregersenQ7175067
Robert M PlengeQ93117290
Daniel L. KastnerQ96817021
Elizabeth W KarlsonQ98839527
Lars AlfredssonQ30349390
Shaun PurcellQ32652871
Elaine F. RemmersQ37369653
John D. RiouxQ37629789
Leonid PadyukovQ42291137
Frederick WolfeQ59689263
P2093author name stringAnnette T Lee
P2860cites workNo association of interleukin-4 gene polymorphisms in Chinese patients with rheumatoid arthritis in TaiwanQ78736879
TNFR2 position 196 polymorphism in Japanese patients with rheumatoid arthritis: comment on the article by Dieudé et alQ78794994
No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypesQ80337674
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseQ22251291
A comprehensive review of genetic association studiesQ22337119
The effects of human population structure on large genetic association studiesQ22337233
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseQ22337234
Assessing the impact of population stratification on genetic association studiesQ22337235
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunitiesQ24537702
Complex genetic predisposition in adult and juvenile rheumatoid arthritisQ24798945
The structure of haplotype blocks in the human genomeQ27860500
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseQ27860821
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritisQ28182995
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritisQ28183279
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseQ28201947
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch populationQ28248685
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom populationQ28255873
Genetic variation in DLG5 is associated with inflammatory bowel diseaseQ28258422
Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitopeQ28266117
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritisQ28267921
Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritisQ77872958
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritisQ78472031
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetesQ28271534
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosusQ28301821
Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effectQ28301839
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetesQ28304750
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisQ28306666
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarctionQ28581447
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetesQ29308585
Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traitsQ29614876
Replication validity of genetic association studiesQ29615456
Genome-wide association studies for common diseases and complex traitsQ29615822
Assessing the probability that a positive report is false: an approach for molecular epidemiology studiesQ29616285
Evolving concepts of rheumatoid arthritisQ29618020
The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE statusQ30160337
A note on robust variance estimation for cluster-correlated dataQ30600512
Chip-based genotyping by mass spectrometryQ30761976
Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up studyQ33565041
A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritisQ33982255
Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibilitQ34113270
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritisQ34114509
Recent findings on genes associated with inflammatory disease.Q34411274
The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritisQ34506331
Case-control studies of association in structured or admixed populations.Q34539216
Genome-wide association studies: theoretical and practical concernsQ34555195
Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident casesQ35201241
Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritisQ35834701
New approaches to gene hunting in IBD.Q35854527
The contribution of HLA to rheumatoid arthritis.Q38695243
HLA-Dw4 in adult and juvenile rheumatoid arthritisQ39842670
Clustering of disease features within 512 multicase rheumatoid arthritis familiesQ40524816
Predicting mortality in patients with rheumatoid arthritisQ40582797
Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis.Q40691132
Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferredQ42617129
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritisQ42631739
Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.Q42673023
Development of rheumatoid arthritis is not associated with two polymorphisms in the Crohn's disease gene CARD15.Q42695065
Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritisQ43505551
Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis.Q44137392
HLA-DRB1 genotype associations in 793 white patients from a rheumatoid arthritis inception cohort: frequency, severity, and treatment biasQ44159740
'Racial' differences in genetic effects for complex diseasesQ44586727
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptideQ44791267
The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean populationQ44931363
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseasesQ46368513
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity geneQ46525978
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish populationQ46584884
Analysis of CARD15/NOD2 haplotypes fails to identify common variants associated with rheumatoid arthritis susceptibility.Q46680320
Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritisQ47948650
Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneityQ50108689
The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955-1985.Q50639396
The influence of sex on the phenotype of rheumatoid arthritis.Q50888543
Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population.Q51497016
Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritisQ52990372
Genome-wide strategies for detecting multiple loci that influence complex diseases.Q53624440
Cytotoxic T-lymphocyte antigen-4-CT60 polymorphism in rheumatoid arthritis.Q54693158
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetesQ56706427
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathiesQ56904666
Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in CaucasiansQ57306878
Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasisQ57533024
Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: Different effects of non-major histocompatibility complex quantitative trait loci in males and femalesQ57533055
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn diseaseQ57606857
SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian populationQ57697279
Tumor necrosis factor receptor type II (exon 6) and interleukin-6 (−174) gene polymorphisms are not associated with family history but tumor necrosis factor receptor type II is associated with hypertension in patients with rheumatoid arthritis fromQ57819629
Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritisQ61658654
A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune DiseasesQ62734302
Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritisQ64461890
HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantationQ67522337
Tumor necrosis factor receptor 2 microsatellite and exon 6 polymorphisms in rheumatoid arthritis in TaiwanQ73064661
CARD15/NOD2 analysis in rheumatoid arthritis susceptibilityQ73537547
The influence of sex on rheumatoid arthritis: a prospective study of onset and outcome after 2 yearsQ75405962
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
SwedenQ34
P304page(s)1044-60
P577publication date2005-12-01
P1433published inAmerican Journal of Human GeneticsQ4744249
P1476titleReplication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4
P478volume77

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Q37070948STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
Q94450975Self-reactive T cells induce and perpetuate chronic relapsing arthritis
Q36027446Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate
Q56890888Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients
Q83208728Shared susceptibility variations in autoimmune diseases: a brief perspective on common issues
Q33519222Simultaneous analysis of all single-nucleotide polymorphisms in genome-wide association study of rheumatoid arthritis
Q33872866Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population
Q33519363Single versus multiple imputation for genotypic data.
Q37401378Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis
Q35011877Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
Q33339386Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus
Q64240473Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset
Q36376793Susceptibility to JRA/JIA: complementing general autoimmune and arthritis traits
Q92684874Susceptible loci associated with autoimmune disease as potential biomarkers for checkpoint inhibitor-induced immune-related adverse events
Q35920930Synovial expression of Th17-related and cancer-associated genes is regulated by the arthritis severity locus Cia10.
Q24288912Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information
Q37324840T cells in rheumatoid arthritis
Q37993692T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man.
Q39818926TCR-CD3ζ gene polymorphisms and expression profile in rheumatoid arthritis.
Q24657292TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
Q41830089TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.
Q43812054The -319C/+49G/CT60G haplotype of CTLA-4 gene confers susceptibility to rheumatoid arthritis in Mexican population
Q36801049The Development of Novel Therapies for Rheumatoid Arthritis
Q37453924The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
Q35605624The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients
Q84444178The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population
Q36392280The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden
Q34661548The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome
Q35108626The expanded human disease network combining protein-protein interaction information.
Q37738107The genetics of juvenile idiopathic arthritis: what is new in 2010?
Q36590524The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility
Q36056490The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients
Q58714558The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
Q50181592The relationship of PADI4_94 polymorphisms with the morbidity of rheumatoid arthritis in Caucasian and Asian populations: a meta-analysis and system review
Q37817050The swollen joint, the thickened artery, and the smoking gun: tobacco exposure, citrullination and rheumatoid arthritis
Q42596336Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study
Q33409947Tissue-specific genetic control of splicing: implications for the study of complex traits
Q96689535Truncated tests for combining evidence of summary statistics
Q36788412Tumor necrosis factor receptor-associated factor 1 influences KRN/I-Ag7 mouse arthritis autoantibody production
Q33706812Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis
Q37729042Update on the genetic risk factors for rheumatoid arthritis
Q33519311Using a higher criticism statistic to detect modest effects in a genome-wide study of rheumatoid arthritis.
Q38122628Validating therapeutic targets through human genetics
Q44532167Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population
Q37755264What does the immunogenetic basis of rheumatoid arthritis teach us about the immunobiology of the disease?
Q37270709What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases
Q34026657Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
Q83497234[Genetics of rheumatoid arthritis]
Q85069904[How do T-cells become activated in joints?]