Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking

scientific article published on 7 May 2008

Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1040542385
P356DOI10.1186/AR2421
P932PMC publication ID2483441
P698PubMed publication ID18462498
P5875ResearchGate publication ID5390127

P50authorImmaculata De VivoQ28805339
Karen H CostenbaderQ87706447
Shun-Chiao ChangQ87894124
Robert M PlengeQ93117290
Elizabeth W KarlsonQ98839527
P2860cites workGenetic signatures of strong recent positive selection at the lactase geneQ24533797
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Q24538382
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide studyQ24657292
A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritisQ24805387
Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W alleleQ24812738
Meta-analysis in clinical trialsQ27860779
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritisQ28183279
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseQ28201947
Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetesQ28237016
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch populationQ28248685
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetesQ28248848
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritisQ28267921
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosusQ28301821
Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effectQ28301839
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancerQ28303909
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisQ28306666
The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE statusQ30160337
Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphataseQ30175917
Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twinsQ31460983
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.Q33942125
A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritisQ33982255
Rheumatoid arthritis. The genetic componentsQ34526896
Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patientsQ34897145
Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident casesQ35201241
Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA.Q35550244
Coffee consumption and risk of rheumatoid arthritisQ35581958
A simple and improved correction for population stratification in case-control studiesQ35752599
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritisQ35752661
Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health StudyQ35941063
The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern SwedenQ36392280
Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in womenQ36496352
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosusQ37070948
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study.Q37486377
Reproductive factors, smoking, and the risk for rheumatoid arthritisQ37787524
Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based studyQ42599672
Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.Q42673023
Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope allelesQ42674479
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullinationQ42676934
Calculating measures of biological interactionQ43922226
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteinsQ44687984
The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcomeQ44800330
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseasesQ46368513
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity geneQ46525978
Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.Q46689842
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British populationQ46721533
Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase familiesQ47985297
The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955-1985.Q50639396
Association between plasma prolactin concentrations and risk of breast cancer among predominately premenopausal women.Q51502917
A SAS program calculating three measures of interaction with confidence intervals.Q52293384
The CTLA4+49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern IrelandQ56902258
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathiesQ56904666
CTLA4 polymorphisms in Spanish patients with rheumatoid arthritisQ56907181
Interaction: A word with two meanings creates confusionQ57224701
Demonstrating stratification in a European American populationQ57418313
Reproductive factors and family history of breast cancer in relation to plasma estrogen and prolactin levels in postmenopausal women in the Nurses' Health Study (United States)Q57751978
Confidence interval estimation of interactionQ67550286
Exogenous sex hormones and the risk of rheumatoid arthritisQ68851681
Reproducibility and validity of self-reported menopausal status in a prospective cohort studyQ69105109
The independence and stability of socioeconomic predictors of morbidity in systemic lupus erythematosusQ72526722
Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of biasQ74028329
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105Q74587900
A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionalsQ77738626
Nodular disease in rheumatoid arthritis: association with cigarette smoking and HLA-DRB1/TNF gene interactionQ78472025
Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4IgQ79290408
PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysisQ79693938
P433issue3
P921main subjectrheumatoid arthritisQ187255
P304page(s)R52
P577publication date2008-05-07
P1433published inArthritis Research and TherapyQ15757229
P1476titleGenetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
P478volume10

Reverse relations

cites work (P2860)
Q35993541A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study
Q57462783An Analytic Approach Using Candidate Gene Selection and Logic Forest to Identify Gene by Environment Interactions (G × E) for Systemic Lupus Erythematosus in African Americans
Q42639562An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis
Q38609269Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis
Q53093196Association between the CTLA-4 +49 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis.
Q88559342Cigarette smoking and the pathogenesis of systemic lupus erythematosus
Q44001527Clonal expansions in selected TCR BV families of rheumatoid arthritis patients are reduced by treatment with the TNFα inhibitors etanercept and infliximab
Q34103237Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk
Q42970803Current concepts in the genetic diagnostics of rheumatoid arthritis.
Q37642588Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
Q34268152Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis
Q51018383Elevated BMI and antibodies to citrullinated proteins interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses' Health Studies.
Q35638839Environmental Basis of Autoimmunity
Q36110733Environmental and gene-environment interactions and risk of rheumatoid arthritis
Q34187692Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis
Q38193918Gene-environment interaction in autoimmune disease
Q31031177Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset
Q35125868Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
Q37218558Genome-wide association studies and gene expression profiles of rheumatoid arthritis: An analysis.
Q28281906Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Q36708347Genomic modulators of the immune response
Q41656686In ACPA-positive RA patients, antibodies to EBNA35-58Cit, a citrullinated peptide from the Epstein-Barr nuclear antigen-1, strongly cross-react with the peptide β60-74Cit which bears the immunodominant epitope of citrullinated fibrin.
Q38235035Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis
Q33895460Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases
Q35762538Modifiable risk factors for RA: prevention, better than cure?
Q34229828Nicotine: specific role in angiogenesis, proliferation and apoptosis
Q34081898PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
Q51604912PTPN22 C1858T and the risk of psoriasis: a meta-analysis.
Q36441438Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies
Q56898076Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis
Q36540858Post-Traumatic Stress Disorder and Risk for Incident Rheumatoid Arthritis
Q38036102Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis
Q37350863Rheumatoid arthritis and smoking: putting the pieces together
Q37315484Rheumatoid arthritis: a view of the current genetic landscape
Q58796858Risk factor assessment of rheumatoid arthritis in North Kerala
Q35053753Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis
Q90207982The Contribution of PTPN22 to Rheumatic Disease
Q34206322The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
Q33642586The genetics and epigenetics of autoimmune diseases
Q50181592The relationship of PADI4_94 polymorphisms with the morbidity of rheumatoid arthritis in Caucasian and Asian populations: a meta-analysis and system review
Q37817050The swollen joint, the thickened artery, and the smoking gun: tobacco exposure, citrullination and rheumatoid arthritis
Q37967566The therapeutic potential of epigenetics in autoimmune diseases.
Q37270709What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases
Q83079598[Effects of smoking on the thyroid gland, digestive system, kidney and bone]

Search more.