A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study

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A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1153316V
P356DOI10.1371/JOURNAL.PONE.0153316
P932PMC publication ID4836711
P698PubMed publication ID27092776
P5875ResearchGate publication ID301534050

P50authorJosef S SmolenQ66753681
František ŠpoutilQ42318175
Guenter SteinerQ45738278
P2093author name stringJozef Rovensky
Zdenko Killinger
Richard Imrich
Adela Penesova
Miroslav Vlcek
Ivana Jochmanova
Ivica Lazurova
Branislav Vohnout
Katarina Krskova
Andrea Marko
Katarina Raslova
Lucia Vernerova
Milada Meskova
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Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control StudiesQ57537059
The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritisQ58234961
Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritisQ58912774
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Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk lociQ37388847
Recent progress in rheumatoid arthritis genetics: one step towards improved patient careQ37443734
Rheumatoid arthritis and metabolic syndromeQ38236740
Measures of human population structure show heterogeneity among genomic regionsQ40509741
A genome-wide screen of gene-gene interactions for rheumatoid arthritis susceptibilityQ42685398
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Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteinsQ44687984
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish populationQ46584884
Activation of interferon regulatory factor 5 by site specific phosphorylationQ24307504
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Q24538382
Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritisQ24812184
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A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritisQ29417158
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritisQ30419111
Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onsetQ31031177
The effect of multiple genetic variants in predicting the risk of type 2 diabetesQ33519326
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex regionQ33868008
The rheumatoid arthritis HLA-DRB1 shared epitopeQ34067135
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian populationQ34081898
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis riskQ34103237
Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markersQ34125266
Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort studyQ34156559
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritisQ34250412
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health recordsQ34458840
The Disease Activity Score and the EULAR response criteriaQ34651201
CTLA-4 and autoimmunity: new insights into the dual regulator of toleranceQ34654251
Genotype score in addition to common risk factors for prediction of type 2 diabetesQ34884376
Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritisQ34897056
Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smokingQ34998359
Mixed lymphocyte cultures in rheumatoid arthritisQ35200536
Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestationsQ35553712
CTLA4 gene polymorphism and autoimmunityQ36079873
Association between PADI4 and rheumatoid arthritis: a meta-analysisQ36383132
Genome-wide linkage and positional association analyses identify associations of novel AFF3 and NTM genes with triglycerides: the GenSalt study.Q36600473
Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patientsQ36679775
Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smokingQ36790341
Non-replication and inconsistency in the genome-wide association settingQ36841272
Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid ArthritisQ37046219
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)e0153316
P577publication date2016-04-19
P1433published inPLOS OneQ564954
P1476titleA Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study
P478volume11

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cites work (P2860)
Q90150217Associations of TRAF1/C5 rs10818488 and rs3761847 polymorphisms with genetic susceptibility to rheumatoid arthritis: a case-control study and updated meta-analysis
Q41470976IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors
Q92570188KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis
Q59791524Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
Q33591346Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis

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