Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

scientific article

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ART.27439
P932PMC publication ID2951335
P698PubMed publication ID20201080
P5875ResearchGate publication ID41722888

P2093author name stringAntony Rosen
Marjan Gucek
Xiaoming Zhu
Felipe Andrade
Erika Darrah
Robert N Cole
P2860cites workDetailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control studyQ21195665
Histone deimination antagonizes arginine methylationQ24302163
Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4Q24310773
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Q24538382
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodiesQ24564876
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritisQ28183279
Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytesQ28210002
PAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseQ28212615
Structural basis for Ca(2+)-induced activation of human PAD4Q28271512
Human PAD4 regulates histone arginine methylation levels via demethyliminationQ28280359
Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrinQ30425949
Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approachQ33264597
Immunity to citrullinated proteins in rheumatoid arthritisQ34732863
Posttranslational modifications of self-antigensQ36193038
Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?Q36683135
High mobility group proteins and their post-translational modificationsQ37015673
Role of histone modifications in defining chromatin structure and functionQ37069217
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.Q37217463
A novel superfamily of enzymes that catalyze the modification of guanidino groups.Q42656917
Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytesQ43858818
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritisQ45091885
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritisQ46453983
Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritisQ46680324
Content of Citrulline and Other Amino-Acids in a Protein of Hair FolliclesQ59094246
Occurrence of Citrulline in ProteinsQ79064459
Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severityQ79843008
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agentsQ81820607
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in KoreansQ82132463
P433issue6
P304page(s)1630-1640
P577publication date2010-06-01
P1433published inArthritis & RheumatologyQ4797636
P1476titleAutocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation
P478volume62

Reverse relations

cites work (P2860)
Q36474561Activation of PAD4 in NET formation
Q89174659Affinity Maturation Drives Epitope Spreading and Generation of Proinflammatory Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis
Q34190363Anti-CCP antibodies: the past, the present and the future
Q50969960Autoantibodies: double agents in human disease.
Q34969938Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity
Q37492376Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis
Q36509456Chemical Proteomic Platform To Identify Citrullinated Proteins
Q35722457Chemical biology of protein arginine modifications in epigenetic regulation
Q38263755Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms.
Q34947947Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53
Q52932746Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features.
Q40697747Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis
Q35202486Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology
Q92734113Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases
Q36588860Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity
Q60920704Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Q42054161Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen During Antigen-Processing
Q37088914Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity
Q37534355Evolution of a mass spectrometry-grade protease with PTM-directed specificity.
Q36508933Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps
Q33952292Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4).
Q34575065Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4
Q37465513Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
Q40834260How citrullination invaded rheumatoid arthritis research
Q48005731Human Deiminases: Isoforms, Substrate Specificities, Kinetics, and Detection
Q38657171Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis
Q35984220Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF.
Q39903023Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.
Q37982673In vivo relevance of citrullinated proteins and the challenges in their detection.
Q43218595Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire
Q42210248Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release.
Q93270547PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets
Q38747640PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis
Q47971862Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation
Q35825742Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis
Q35830530Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions
Q45137792Presence and role of anti-citrullinated protein antibodies in experimental arthritis models
Q86301346Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases
Q33729177Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.
Q38435747Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis
Q40895418The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis
Q38061870The protein arginine deiminases: Structure, function, inhibition, and disease.
Q44436437Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis

Search more.