Citrullination of autoantigens: upstream of TNFα in the pathogenesis of rheumatoid arthritis.

scientific article published on 23 June 2011

Citrullination of autoantigens: upstream of TNFα in the pathogenesis of rheumatoid arthritis. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.FEBSLET.2011.06.006
P698PubMed publication ID21704035
P5875ResearchGate publication ID51248672

P50authorAndrew KinlochQ81459128
P2093author name stringPatrick J Venables
Anne-Marie Quirke
Benjamin A C Fisher
P2860cites workHistone deimination antagonizes arginine methylationQ24302163
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Q24538382
RANK is essential for osteoclast and lymph node developmentQ24598872
Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritisQ24629328
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide studyQ24657292
Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritisQ24801080
Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritisQ24813085
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritisQ28183279
PAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseQ28212615
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom populationQ28255873
Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6Q28256812
Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritisQ28264978
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritisQ28267921
Association between PADI4 and rheumatoid arthritis: a replication studyQ28275244
Human PAD4 regulates histone arginine methylation levels via demethyliminationQ28280359
Cytokines in the pathogenesis of rheumatoid arthritisQ28303865
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisQ28306666
Protein carbamylation links inflammation, smoking, uremia and atherogenesis.Q30364367
A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritisQ33982255
Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies.Q34015846
Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.Q34027609
The rheumatoid arthritis HLA-DRB1 shared epitopeQ34067135
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian populationQ34081898
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular trapsQ34096547
HLA class II association with rheumatoid arthritis: facts and interpretationsQ34132727
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritisQ34137749
Twin concordance rates for rheumatoid arthritis: results from a nationwide study.Q34357436
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.Q34388910
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish populationQ46584884
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cellsQ46643896
Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogenQ46724742
Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticleQ46847500
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammationQ46925018
Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England.Q50925165
Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins.Q51032043
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.Q52917057
A "case control" study on the rôle of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO).Q53348043
2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiativeQ56506042
Rheumatoid arthritisQ57349151
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalisQ58023171
Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their RelativesQ58234823
Identification of citrullinated vimentin peptides as T cell epitopes in HLAâ DR4â positive patients with rheumatoid arthritisQ58234841
Decreasing incidence and prevalence of rheumatoid arthritis in pima indians over a twenty-five—year periodQ59150875
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritisQ34498921
Citrullination: a posttranslational modification in health and diseaseQ34531257
Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health StudyQ34604666
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritisQ35011877
Immune dysregulation by the rheumatoid arthritis shared epitopeQ35037009
A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French populationQ35555382
The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destructionQ35637373
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritisQ35752661
Erosive arthritisQ35901078
Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapy.Q36006214
Rheumatoid arthritis in American Indians and Alaska Natives: a review of the literatureQ36031009
Use and significance of anti-CCP autoantibodies in rheumatoid arthritisQ36270234
Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritisQ36294995
Monocytes regulate osteoclast-activating factor production by releasing prostaglandinsQ36342717
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic miceQ36537972
Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!Q36639940
Cigarette smoking and autoimmune disease: what can we learn from epidemiology?Q36677000
Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritisQ36955312
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.Q37124853
Rheumatoid arthritis and smoking: putting the pieces togetherQ37350863
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritisQ37700775
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritisQ39875697
Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalisQ40512781
Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitriteQ40917292
Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll‐like receptor 4 and Fcγ receptorQ41612590
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteinsQ41825751
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophagesQ41855355
Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.Q41870758
Citrullination is an inflammation-dependent processQ42140650
A novel superfamily of enzymes that catalyze the modification of guanidino groups.Q42656917
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullinationQ42676934
Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritisQ42874449
Anticitrulline antibodies can be caused by homocitrulline-containing proteins in rabbits.Q42975230
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritisQ44064388
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisQ44616885
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteinsQ44687984
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort studyQ44800314
The presence of citrullinated proteins is not specific for rheumatoid synovial tissueQ45141270
Determination of cyanide exposure by gas chromatography-mass spectrometry analysis of cyanide-exposed plasma proteins.Q45589696
An intriguing relationship between the immune response to citrullinated vimentin and the HLA shared epitope: comment on the article by Verpoort et al.Q46343359
Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase.Q46343375
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritisQ46439121
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritisQ46453983
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
pathogenesisQ372016
P304page(s)3681-3688
P577publication date2011-06-23
P1433published inFEBS LettersQ1388051
P1476titleCitrullination of autoantigens: upstream of TNFα in the pathogenesis of rheumatoid arthritis
P478volume585

Reverse relations

cites work (P2860)
Q53132137Anti-citrullinated protein antibodies activated ERK1/2 and JNK mitogen-activated protein kinases via binding to surface-expressed citrullinated GRP78 on mononuclear cells.
Q52932746Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features.
Q28085328Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity
Q40401924Epidemiology: Then and Now.
Q34568233Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages
Q35946934Gilt required for RTL550-CYS-MOG to treat experimental autoimmune encephalomyelitis
Q37465513Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
Q40834260How citrullination invaded rheumatoid arthritis research
Q38632859Incidence of inflammatory joint diseases in Finland: results from a population-based epidemiological study
Q34105680Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis
Q37690985Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease
Q40081890The case for periodontitis in the pathogenesis of rheumatoid arthritis
Q51679039The dependency on neighboring amino acids for reactivity of anti-citrullinated protein antibodies to citrullinated proteins.
Q27022645The effect of targeted rheumatoid arthritis therapies on anti-citrullinated protein autoantibody levels and B cell responses
Q36456814The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA.
Q64945497The inflammatory function of human IgA.

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