Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor

scientific article published on 02 May 2019

Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS20092174
P953full work available at URLhttps://www.mdpi.com/1422-0067/20/9/2174
P932PMC publication ID6539144
P698PubMed publication ID31052493

P50authorEwa BieleckaQ56191688
Joanna KozielQ90311708
Marta KamińskaQ91742536
Katherine FalkowskiQ91742540
Danuta BryzekQ91742544
Tomasz KantykaQ92702131
Malgorzata BenedykQ92741093
Piotr MydelQ97424901
P2093author name stringAlicia Wong
Ardita Aliko
Stanisław Malicki
P2860cites workHistone deimination antagonizes arginine methylationQ24302163
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Q24538382
Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesisQ26991867
Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype geneQ27666536
Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective InhibitorsQ27675108
Neutrophil extracellular traps kill bacteriaQ27860996
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritisQ28183279
PAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseQ28212615
Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity.Q30523071
Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV.Q33219645
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminaseQ33876323
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.Q33907872
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular trapsQ34096547
Anti-CCP Antibody, a Marker for the Early Detection of Rheumatoid ArthritisQ34601833
Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular trapsQ34751933
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.Q34904630
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitorQ35057027
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.Q35549296
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritisQ35825742
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responsesQ36925292
NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritisQ37056181
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potentialQ37165601
Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs.Q37282551
Citrullination under physiological and pathological conditionsQ37988241
The protein arginine deiminases: Structure, function, inhibition, and disease.Q38061870
Lessons to be learned from periodontitisQ38078201
Biological relevance of citrullinations: diagnostic, prognostic and therapeutic optionsQ38292450
Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activityQ38946971
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritisQ38995539
An emerging role for neutrophil extracellular traps in noninfectious diseaseQ39166302
The case for periodontitis in the pathogenesis of rheumatoid arthritisQ40081890
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritisQ40697747
A novel superfamily of enzymes that catalyze the modification of guanidino groups.Q42656917
A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluationQ42855831
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitorsQ43076584
Porphyromonas gingivalis peptidylarginine deiminase substrate specificityQ43660031
Citrullination of synovial proteins in murine models of rheumatoid arthritisQ44586791
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritisQ45091885
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammationQ46925018
Conserved Citrullinating Exoenzymes in Porphyromonas SpeciesQ47234763
Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients.Q48333733
A novel microtubule independent effect of paclitaxel: the inhibition of peptidylarginine deiminase from bovine brainQ48375587
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrixQ59131874
Extraction, purification and analysis of histonesQ80422717
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in KoreansQ82132463
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2174
P577publication date2019-01-01
2019-05-02
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleDiscovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor
P478volume20

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cites work (P2860)
Q92314304An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders
Q90452458Increased Circulating Levels of Neutrophil Extracellular Traps During Cardiopulmonary Bypass
Q92421763Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases

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