Pathogenic role of antibodies to citrullinated proteins in rheumatoid arthritis

scientific article published on May 2006

Pathogenic role of antibodies to citrullinated proteins in rheumatoid arthritis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1586/1744666X.2.3.365
P698PubMed publication ID20476908

P2093author name stringPatrick J Venables
David Moyes
Andrew J Kinloch
Karin E Lundberg
P2860cites workDetailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control studyQ21195665
Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentinQ21195679
Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)Q22010390
Histone deimination antagonizes arginine methylationQ24302163
Comparison of enzymatic properties between hPADI2 and hPADI4Q24337201
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in KoreansQ82132463
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Q24538382
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodiesQ24564876
The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodiesQ24628871
Anti-keratin antibodies in rheumatoid arthritisQ24678035
Autoantibody profile in rheumatoid arthritis during long-term infliximab treatmentQ24800888
Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritisQ24801080
Insights into rheumatoid arthritis derived from the Sa immune systemQ24805044
Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritisQ24813085
Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severityQ24816615
Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritisQ24816803
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritisQ28183279
Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's diseaseQ28185679
Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytesQ28210002
PAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseQ28212615
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom populationQ28255873
Association between PADI4 and rheumatoid arthritis: a replication studyQ28275244
Human PAD4 regulates histone arginine methylation levels via demethyliminationQ28280359
Immunoscreening of phage-displayed cDNA-encoded polypeptides identifies B cell targets in autoimmune diseaseQ30863519
Effects of paclitaxel on cultured synovial cells from patients with rheumatoid arthritisQ31000977
Increased peptidylarginine deiminase type II in hypoxic astrocytesQ31130784
Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twinsQ31460983
The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrinQ32133798
Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosisQ33211732
Redefining the HLA and RA association: to be or not to be anti-CCP positive.Q33341777
A NEW SERUM FACTOR IN PATIENTS WITH RHEUMATOID ARTHRITIS; THE ANTIPERINUCLEAR FACTOR.Q33626291
TNF signaling in vascular endothelial cellsQ34288800
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.Q34388910
Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermisQ34394482
Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti-citrullinated protein antibodies in rheumatoid arthritisQ34498497
Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritisQ34650192
Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective studyQ34896439
Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis is associated with clinical improvementQ35553375
Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP).Q35554533
Rheumatoid factor, but not anti-cyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritisQ35555152
A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French populationQ35555382
Blockade of tumour necrosis factor {alpha} significantly alters the serum level of IgG- and IgA-rheumatoid factor in patients with rheumatoid arthritis.Q35555920
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritisQ35556014
Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodiesQ35556073
The effect of etanercept on anti-cyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritisQ35636615
Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope allelesQ35636886
Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific markerQ35941559
Rheumatoid factor on a daily basisQ36086125
Use and significance of anti-CCP autoantibodies in rheumatoid arthritisQ36270234
Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritisQ36294995
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study.Q37486377
Granulocyte-specific antinuclear antibodies. Possible significance for the pathogenesis, clinical features and diagnosis of rheumatoid arthritisQ40099221
The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritisQ40304964
Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donorsQ40532147
Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis.Q41824468
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophagesQ41855355
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritisQ42631739
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullinationQ42676934
Methotrexate effect on anti-cyclic citrullinated peptide antibody levels in rheumatoid arthritisQ43048544
Production of anti-CCP antibodies and matrix metalloproteinase-3 by human rheumatoid arthritis synovial tissues using SCID miceQ43048637
Citrullination and autoimmune disease: 8th Bertine Koperberg meetingQ43049440
Peptidylarginine deiminase: a candidate factor in demyelinating diseaseQ44027704
Defects in the regulation of B cell apoptosis are required for the production of citrullinated peptide autoantibodies in miceQ44541039
Citrullination of synovial proteins in murine models of rheumatoid arthritisQ44586791
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisQ44616885
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteinsQ44687984
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptideQ44791267
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort studyQ44800314
Citrullination of self-proteins and autoimmunityQ44967035
Absence of citrulline-specific autoantibodies in animal models of autoimmunityQ44973891
Influence of arginine deimination on antigenicity of fibrinogenQ45027012
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritisQ45091885
The presence of citrullinated proteins is not specific for rheumatoid synovial tissueQ45141270
Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitidesQ46425912
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritisQ46439121
Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calciumQ46464269
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish populationQ46584884
Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunityQ46625270
Citrullination of fibronectin in rheumatoid arthritis synovial tissueQ46655039
A novel microtubule independent effect of paclitaxel: the inhibition of peptidylarginine deiminase from bovine brainQ48375587
Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome.Q50747871
Genetic and genomic studies of PADI4 in rheumatoid arthritisQ57667794
Alpha-enolase: a novel cytosolic autoantigen in ANCA positive vasculitisQ70616885
Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1Q73053618
In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serumQ73486207
Identification of the gene loci that predispose to rheumatoid arthritisQ77786365
Antibodies against cyclic citrullinated peptides in patients affected by rheumatoid arthritis before and after infliximab treatmentQ81430222
P433issue3
P921main subjectrheumatoid arthritisQ187255
P304page(s)365-375
P577publication date2006-05-01
P1433published inExpert Review of Clinical ImmunologyQ15733763
P1476titlePathogenic role of antibodies to citrullinated proteins in rheumatoid arthritis
P478volume2

Reverse relations

cites work (P2860)
Q51070244Antibodies to Cyclic Citrullinated Peptides in Patients With Juvenile Idiopathic Arthritis and Patients With Rheumatoid Arthritis: Shared Expression of the Inherently Autoreactive 9G4 Idiotype.
Q36204117Autoantibodies binding to citrullinated telopeptide of type II collagen and to cyclic citrullinated peptides predict synergistically the development of seropositive rheumatoid arthritis
Q37039335B cells as effectors and regulators of sex-biased arthritis.
Q37754775Citrullinated collagens in the pathogenesis of rheumatoid arthritis
Q43162163Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis
Q33886419Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice

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