| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0952-7915(97)80088-X |
| P698 | PubMed publication ID | 9203419 |
| P50 | author | Benjamin G. Neel | Q59158915 |
| P2093 | author name string | Neel BG | |
| P2860 | cites work | Profound block in thymocyte development in mice lacking p56lck | Q24298882 |
| Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase) | Q24301219 | ||
| Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions | Q24307776 | ||
| PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase | Q24308342 | ||
| Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C | Q24309230 | ||
| Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C | Q24309260 | ||
| CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation | Q24310493 | ||
| cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain | Q24311784 | ||
| Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 | Q24314461 | ||
| Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor | Q24318464 | ||
| Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro | Q24318630 | ||
| Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases | Q24323070 | ||
| Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1 | Q24323312 | ||
| Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains | Q70664749 | ||
| A tyrosine-phosphorylated 110-120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells | Q71425907 | ||
| Protein tyrosine phosphatases and the control of cellular signaling responses | Q71475516 | ||
| CD45 protein-tyrosine phosphatase associates with the WW domain-containing protein, CD45AP, through the transmembrane region | Q71585736 | ||
| Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C | Q71701862 | ||
| Distinct isoforms of the CD45 protein-tyrosine phosphatase differentially regulate interleukin 2 secretion and activation signal pathways involving Vav in T cells | Q71743398 | ||
| CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells | Q71825314 | ||
| CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells | Q71833551 | ||
| Point mutation in the second phosphatase domain of CD45 abrogates tyrosine phosphatase activity | Q72401998 | ||
| CD45 protein-tyrosine phosphatase is specifically associated with a 116-kDa tyrosine-phosphorylated glycoprotein | Q72466163 | ||
| Regulation of B-cell activation by CD45: a question of mechanism | Q72768326 | ||
| Induction of protein-tyrosine phosphatase LC-PTP by IL-2 in human T cells. LC-PTP is an early response gene | Q72770999 | ||
| Protein tyrosine phosphatases | Q72882944 | ||
| Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3'-kinase in myeloid cells | Q73427529 | ||
| Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation | Q24329121 | ||
| Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. | Q24647903 | ||
| Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells | Q24677276 | ||
| Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling | Q24678964 | ||
| Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization | Q27733166 | ||
| Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP | Q28118925 | ||
| Origin of murine B cell lineages | Q28268291 | ||
| Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45 | Q28271742 | ||
| The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells | Q28279049 | ||
| Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling | Q28279660 | ||
| FAP-1: a protein tyrosine phosphatase that associates with Fas | Q28287693 | ||
| Characterization of a novel protein-binding module--the WW domain | Q28295526 | ||
| Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product | Q28300755 | ||
| Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase | Q28300799 | ||
| CD22 is a negative regulator of B-cell receptor signalling | Q28302610 | ||
| Apoptosis by death factor | Q28304002 | ||
| Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice | Q28504799 | ||
| Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase | Q28507508 | ||
| Differential requirements of CD45 for lymphocyte development and function | Q28508466 | ||
| Hyperresponsive B cells in CD22-deficient mice | Q28510573 | ||
| Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice | Q28510812 | ||
| CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation | Q28511906 | ||
| Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells | Q28588373 | ||
| Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 | Q28592092 | ||
| A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP | Q28615693 | ||
| Recognition of unique carboxyl-terminal motifs by distinct PDZ domains | Q29547580 | ||
| The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes | Q30193457 | ||
| Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness | Q30453894 | ||
| Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. | Q34308479 | ||
| From form to function: signaling by protein tyrosine phosphatases. | Q34405391 | ||
| Protein tyrosine phosphatases in signal transduction. | Q34419522 | ||
| Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain | Q35886042 | ||
| Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production | Q36229904 | ||
| The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations | Q36231744 | ||
| Eosinophilia in transgenic mice expressing interleukin 5. | Q36353850 | ||
| Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation. | Q36362458 | ||
| Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice | Q36366149 | ||
| B and T cells are not required for the viable motheaten phenotype | Q36366195 | ||
| Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases | Q36676146 | ||
| CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli | Q36730988 | ||
| The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation | Q37635718 | ||
| Genetically determined murine models of immunodeficiency | Q39657786 | ||
| Self-tolerance checkpoints in B lymphocyte development | Q40373293 | ||
| Of ITAMs and ITIMs: turning on and off the B cell antigen receptor | Q40400995 | ||
| Regulation of immune function by protein tyrosine phosphatases | Q40404832 | ||
| Signaling through the hematopoietic cytokine receptors. | Q40444894 | ||
| MHC-recognizing receptors: they're not just for T cells anymore. | Q40451337 | ||
| Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function | Q40631138 | ||
| CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development | Q40661212 | ||
| Molecular basis of the motheaten phenotype | Q40694874 | ||
| Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction | Q40756303 | ||
| Inhibitory MHC class I receptors on NK cells and T cells | Q41113089 | ||
| Reversible phosphorylation and mitotic control | Q41133357 | ||
| Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation | Q41147414 | ||
| Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. | Q41166947 | ||
| An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line. | Q41182907 | ||
| Form and function in protein dephosphorylation | Q41193500 | ||
| The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation | Q41255832 | ||
| The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? | Q41285966 | ||
| Characterization of the Interaction between CD45 and CD45-AP | Q41296604 | ||
| Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation. | Q41302172 | ||
| Antigen receptor‐initiated growth inhibition is blocked in CD45‐loss variants of a mature B lymphoma, with limited effects on apoptosis | Q41315932 | ||
| Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein | Q41334085 | ||
| Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis | Q41357125 | ||
| Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. | Q41471767 | ||
| Negative regulation of apoptotic death in immature B cells by CD45. | Q41477790 | ||
| Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45. | Q41559108 | ||
| Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. | Q41678661 | ||
| Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain | Q42064327 | ||
| Fibronectin type III modules in the receptor phosphatase CD45 and tapeworm antigens | Q42843098 | ||
| Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase | Q46161173 | ||
| Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. | Q46463458 | ||
| Inhibitory MHC class I receptors on NK and T cells: a standard nomenclature | Q48787037 | ||
| CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. | Q52198671 | ||
| Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells. | Q53442265 | ||
| CD22 regulates thymus-independent responses and the lifespan of B cells. | Q55066830 | ||
| Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4 | Q56908993 | ||
| Regulation of lymphocyte activation by the cell-surface molecule CD22 | Q56964563 | ||
| Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells | Q57185508 | ||
| A role for CD5 in TCR-mediated signal transduction and thymocyte selection | Q57198373 | ||
| Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway | Q59068009 | ||
| Prevention and reversal of renal allograft rejection by antibody against CD45RB | Q60079374 | ||
| Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation | Q69355760 | ||
| P433 | issue | 3 | |
| P304 | page(s) | 405-420 | |
| P577 | publication date | 1997-06-01 | |
| P1433 | published in | Current Opinion in Immunology | Q15752917 |
| P1476 | title | Role of phosphatases in lymphocyte activation | |
| P478 | volume | 9 |
| Q35179402 | A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis |
| Q77719710 | Abnormal pattern of tyrosine phosphorylation in unstimulated peripheral blood T lymphocytes from patients with systemic lupus erythematosus |
| Q33961297 | Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps |
| Q46113259 | An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity |
| Q41750955 | Analysis of antigen receptor signalling using mouse gene targeting |
| Q28140552 | Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk |
| Q74144662 | CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection |
| Q24554515 | CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1 |
| Q28145666 | CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling |
| Q34180660 | Combinatorial control of the specificity of protein tyrosine phosphatases |
| Q28359634 | Comparative study of protein tyrosine phosphatase-epsilon isoforms: membrane localization confers specificity in cellular signalling |
| Q35705524 | Dileucine and YXXL motifs in the cytoplasmic tail of the bovine leukemia virus transmembrane envelope protein affect protein expression on the cell surface |
| Q42811183 | Distribution of the src-homology-2-domain-containing inositol 5-phosphatase SHIP-2 in both non-haemopoietic and haemopoietic cells and possible involvement of SHIP-2 in negative signalling of B-cells |
| Q28185990 | Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells |
| Q34034843 | ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury |
| Q73104360 | Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo |
| Q22254637 | FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells |
| Q57364728 | Fc receptor-mediated phagocytosis |
| Q41732769 | Genetic analysis of protein tyrosine phosphatases |
| Q34203817 | Greater frequency of CD5-negative CD8(+) T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation |
| Q22010565 | Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity |
| Q34170862 | IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex |
| Q24522530 | Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages |
| Q34941159 | Impact of oxidative stress on signal transduction control by phosphotyrosine phosphatases |
| Q36370009 | Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell |
| Q34763949 | Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck |
| Q38302734 | Intercellular adhesion molecule-1 (ICAM-1) gene expression in human T cells is regulated by phosphotyrosyl phosphatase activity. Involvement of NF-kappaB, Ets, and palindromic interferon-gamma-responsive element-binding sites |
| Q27004012 | Intestine immune homeostasis after alcohol and burn injury |
| Q43648824 | Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts |
| Q40724050 | Molecular mechanisms underlying SHP-1 gene expression |
| Q31032344 | PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit |
| Q40996486 | Peptide antagonism and T cell receptor interactions with peptide-MHC complexes |
| Q77366768 | Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen |
| Q30653230 | Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis |
| Q36713273 | Protein tyrosine phosphatase function: the substrate perspective |
| Q77946535 | Protein tyrosine phosphatases: counting the trees in the forest |
| Q77481930 | Recent advances in the understanding of interleukin-2 signal transduction |
| Q77785363 | Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts |
| Q36011208 | Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells |
| Q22010599 | Regulation of acidification and apoptosis by SHP-1 and Bcl-2 |
| Q41650140 | Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase |
| Q39674676 | Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts |
| Q40784834 | Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation |
| Q24290736 | SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways |
| Q28284908 | SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors |
| Q33958723 | SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation |
| Q43611489 | Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes |
| Q37063739 | Signaling defects in anti-tumor T cells |
| Q31942406 | Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation |
| Q28211340 | Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase |
| Q45345628 | Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity |
| Q37002380 | Survival of monocytes and macrophages and their role in health and disease |
| Q31936284 | Switched at birth: a new family for PECAM-1. |
| Q77419198 | T cells with a quiescent phenotype (CD45RA+) are overabundant in the blood and involuted lymphoid tissues in wasting protein and energy deficiencies |
| Q41008340 | The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1. |
| Q28205975 | The SOCS box: a tale of destruction and degradation |
| Q77631387 | The diversity and possible functions of the inositol polyphosphate 5-phosphatases |
| Q35076675 | The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits |
| Q28144584 | The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2 |
| Q40682176 | Treatment of human T cells with bisperoxovanadium phosphotyrosyl phosphatase inhibitors leads to activation of cyclooxygenase-2 gene |
| Q37271492 | Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice |
| Q34827219 | src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation |
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