Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research

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Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2015.00020
P932PMC publication ID4322731
P698PubMed publication ID25713537
P5875ResearchGate publication ID271405934

P2093author name stringThomas Friedrich
Kirstin Hobiger
P2860cites workVoltage-Controlled Enzymes: The New JanusBifronsQ21129281
The lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activitiesQ22009915
A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and YQ22010933
Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomesQ24290296
Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activationQ24290536
Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activationQ24290901
Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulationQ24297363
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclinsQ24314904
The purification and characterization of a human dual-specific protein tyrosine phosphataseQ24315749
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexesQ24318882
Structure of human PIR1, an atypical dual-specificity phosphataseQ24321790
Coupling of the phosphatase activity of Ci-VSP to its voltage sensor activity over the entire range of voltage sensitivityQ48676430
What if higher plants lack a CDC25 phosphatase?Q49074647
Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediateQ50335611
Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian.Q51892982
The catalytic acid in the dephosphorylation of the Cdk2-pTpY/CycA protein complex by Cdc25B phosphatase.Q54791217
The 18 kDa cytosolic acid phosphatase from bovine liver has phosphotyrosine phosphatase activity on the autophosphorylated epidermal growth factor receptorQ58199761
Aspartic-129 is an essential residue in the catalytic mechanism of the low M r phosphotyrosine protein phosphataseQ58291404
Red Cell Acid Phosphatase Variants: A New Human PolymorphismQ59068918
Leaving group dependence and proton inventory studies of the phosphorylation of a cytoplasmic phosphotyrosyl protein phosphatase from bovine heartQ68253861
The molecular basis of the differing kinetic behavior of the two low molecular mass phosphotyrosine protein phosphatase isoformsQ70937660
The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphataseQ72607148
Comparative kinetic analysis and substrate specificity of the tandem catalytic domains of the receptor-like protein-tyrosine phosphatase alphaQ73119344
Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1Q73243848
Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2Q73836216
Dual-specific Cdc25B phosphatase: in search of the catalytic acidQ74290644
Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulationQ74457509
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatasesQ24323070
14-3-3 proteins associate with cdc25 phosphatasesQ24324041
Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LARQ24556532
Expression cloning of a human dual-specificity phosphataseQ24562377
A catalytic mechanism for the dual-specific phosphatasesQ24563405
Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.Q24647903
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationQ24677034
ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interfaceQ27301222
The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanismQ27619897
Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycleQ27620131
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediateQ27641430
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1BQ27641431
Insights into the Reaction of Protein-tyrosine Phosphatase 1B: CRYSTAL STRUCTURES FOR TRANSITION STATE ANALOGS OF BOTH CATALYTIC STEPSQ27660261
Crystal Structure of the Cytoplasmic Phosphatase and Tensin Homolog (PTEN)-like Region of Ciona intestinalis Voltage-sensing Phosphatase Provides Insight into Substrate Specificity and Redox Regulation of the Phosphoinositide Phosphatase ActivityQ27667692
A glutamate switch controls voltage-sensitive phosphatase functionQ27678935
Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substratesQ27685301
Crystal structure of bovine heart phosphotyrosyl phosphatase at 2.2-A resolutionQ27729419
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1BQ27729426
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstateQ27730850
The crystal structure of a low-molecular-weight phosphotyrosine protein phosphataseQ27730852
Crystal structure of human protein tyrosine phosphatase 1BQ27731235
Crystal structure of the dual specificity protein phosphatase VHRQ27732778
Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallographyQ27749490
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25AQ27757908
Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificityQ27765114
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
PTEN and myotubularin: novel phosphoinositide phosphatasesQ27937321
Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphataseQ28115861
Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydratesQ28116113
PTEN: The down side of PI 3-kinase signalling.Q34540849
Oxidants painting the cysteine chapel: redox regulation of PTPsQ34552511
Purification of the major protein-tyrosine-phosphatases of human placentaQ34554142
Characterization of the major protein-tyrosine-phosphatases of human placenta.Q34554150
Tumor suppressor PTEN acts through dynamic interaction with the plasma membraneQ34574432
A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor.Q34609218
Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.Q34648275
Pten signaling in gliomasQ34707865
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatasesQ34765642
Low molecular weight protein tyrosine phosphatases: small, but smart.Q34777984
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphateQ34784803
Targeting protein tyrosine phosphatases for anticancer drug discoveryQ34789961
Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphataseQ34891762
The linker pivot in Ci-VSP: the key to unlock catalysisQ34906624
Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential.Q34979031
CD45: a critical regulator of signaling thresholds in immune cellsQ34987899
The two faces of PTP1B in cancerQ35005347
Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistanceQ35023360
Dissecting the catalytic mechanism of protein-tyrosine phosphatasesQ35063279
Membrane-binding and activation mechanism of PTEN.Q35145882
Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferationQ35146110
Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularinQ35584128
Redox regulation of PTEN and protein tyrosine phosphatases in H(2)O(2) mediated cell signalingQ35689670
Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancerQ35861503
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebratesQ35933396
Functions and mechanisms of redox regulation of cysteine-based phosphatasesQ36124979
Redox redux: revisiting PTPs and the control of cell signalingQ36151514
Evolution of the voltage sensor domain of the voltage-sensitive phosphoinositide phosphatase VSP/TPTE suggests a role as a proton channel in eutherian mammalsQ36179844
Redox regulation of PI 3-kinase signalling via inactivation of PTENQ36266420
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45Q36403197
Cdc25: mechanisms of checkpoint inhibition and recoveryQ36471975
Regulation of PTEN function as a PIP3 gatekeeper through membrane interactionQ36544446
Emerging roles of nuclear protein phosphatasesQ36743535
Cdc25 phosphatases: structure, specificity, and mechanismQ36747424
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosisQ34040409
Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancerQ34087341
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probesQ34089143
Family ties of gated pores: evolution of the sensor moduleQ34153984
Combinatorial control of the specificity of protein tyrosine phosphatasesQ34180660
Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependenceQ34187806
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP)Q34278006
Low-molecular-weight protein tyrosine phosphatase is a positive component of the fibroblast growth factor receptor signaling pathwayQ34279545
A human phospholipid phosphatase activated by a transmembrane control moduleQ34294291
Protein tyrosine phosphatases as potential therapeutic targetsQ34295063
Functional diversity of voltage-sensing phosphatases in two urodele amphibiansQ34297477
Protein tyrosine phosphatases: prospects for therapeuticsQ34318066
Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons.Q34328870
Substrate-trapping techniques in the identification of cellular PTP targetsQ34374862
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensorQ34419859
Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsyQ34444806
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathwayQ28142838
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphateQ28186818
An overview of the protein tyrosine phosphatase superfamilyQ28188951
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipidsQ28203936
Cdc25C interacts with PCNA at G2/M transitionQ28207568
Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1Q28212329
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxisQ28242514
Protein tyrosine phosphatases in the human genomeQ28265924
Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphataseQ28266581
The structure and mechanism of protein phosphatases: insights into catalysis and regulationQ28275119
Cdc25 phosphatases and cancerQ28278269
Protein tyrosine phosphatases: mechanisms of catalysis and regulationQ28288979
Enzymatic detoxification of cyanide: clues from Pseudomonas aeruginosa RhodaneseQ28289954
TPIP: a novel phosphoinositide 3-phosphataseQ28364566
Dual mode of degradation of Cdc25 A phosphataseQ28386155
Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymesQ28583016
The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene familyQ28588732
Rapid destruction of human Cdc25A in response to DNA damageQ28611930
The TPTE gene family: cellular expression, subcellular localization and alternative splicingQ28678657
A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogenQ29347520
Protein tyrosine phosphatases: from genes, to function, to diseaseQ29614826
Reversible inactivation of the tumor suppressor PTEN by H2O2Q29615204
Prediction of a ligand-induced conformational change in the catalytic core of Cdc25A.Q30325800
Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.Q30441600
HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.Q30828692
The cdk-activating kinase (CAK): from yeast to mammals.Q33585306
Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screeningQ33600807
Tyrosine phosphorylation of A17 during vaccinia virus infection: involvement of the H1 phosphatase and the F10 kinase.Q33649199
The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relationsQ33758088
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.Q33802097
Phosphoinositide phosphatases in cell biology and diseaseQ33862413
A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicingQ33862828
Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21.Q33921281
PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphataseQ33940647
Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domainQ33974931
Identification of new inhibitors for low molecular weight protein tyrosine phosphatase isoform B.Q43966806
Catalytic mechanism of Cdc25.Q44237172
Kidney specific expression of cTPTE during development of the chick embryoQ44247237
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.Q44705461
Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bondQ44862123
Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation.Q45094371
Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensorQ45323409
Protein phosphorylation in signaling--50 years and countingQ46541371
Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancersQ46612262
Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer developmentQ46762835
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changesQ46791213
The low-molecular-weight acid phosphatase from bovine liver: isolation, amino acid composition, and chemical modification studiesQ47287151
Site-directed mutagenesis, kinetic, and spectroscopic studies of the P-loop residues in a low molecular weight protein tyrosine phosphataseQ47322995
Subcellular distribution of low- and high-molecular-weight acid phosphatasesQ47335093
Alterations of low molecular weight acid phosphatase protein level in Alzheimer's diseaseQ47343610
Asp129 of low molecular weight protein tyrosine phosphatase is involved in leaving group protonationQ47367748
Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brainsQ47392334
Cloning, expression and characterisation of a new human low Mr phosphotyrosine protein phosphatase originating by alternative splicing.Q47763944
cdc25+ functions as an inducer in the mitotic control of fission yeastQ48366414
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal LectureQ48575949
Allergy and ACP1 genetic polymorphismQ36772729
Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysisQ36799816
PTP1B as a drug target: recent developments in PTP1B inhibitor discoveryQ36805716
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
CDC25 phosphatases in cancer cells: key players? Good targets?Q36849329
Protein tyrosine phosphatases: dual-specificity phosphatases in health and diseaseQ37094068
Protein tyrosine phosphatases: structure-function relationshipsQ37094073
Glycogen and its metabolism: some new developments and old themesQ37095413
Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulationsQ37153228
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP.Q37267670
Evolution of protein phosphatases in plants and animalsQ37355920
Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphataseQ37365173
PTP1B: a double agent in metabolism and oncogenesisQ37728307
PI(3)king apart PTEN's role in cancer.Q37771785
Voltage-sensing phosphatase: its molecular relationship with PTEN.Q37847813
Regulation of protein tyrosine phosphatases by reversible oxidationQ37920470
Regulation of intracellular signalling through cysteine oxidation by reactive oxygen speciesQ37979774
New insights in the activity of voltage sensitive phosphatasesQ38000457
Redox regulation of tumor suppressor PTEN in cancer and aging (Review).Q38073546
Biochemistry and structure of phosphoinositide phosphatasesQ38076803
Protein tyrosine phosphatases: structure, function, and implication in human disease.Q38122079
PTP1B: a simple enzyme for a complex worldQ38123537
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human diseaseQ38125356
The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.Q38288824
Redox regulation of the tumor suppressor PTEN by glutathioneQ39679407
Differential redox regulation within the PTP superfamilyQ40161680
Redox regulation of PTEN by S-nitrosothiolsQ40406877
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motifQ40601438
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transitionQ40793182
Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulationQ40795994
The cdc25B phosphatase is essential for the G2/M phase transition in human cellsQ41021031
Structural, catalytic, and functional properties of low M(r), phosphotyrosine protein phosphatases. Evidence of a long evolutionary history.Q41467925
Identification of an essential acidic residue in Cdc25 protein phosphatase and a general three-dimensional model for a core region in protein phosphatasesQ41492501
Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.Q41501980
Structure and function of the low Mr phosphotyrosine protein phosphatasesQ41633407
The role of CD45 and CD45-associated molecules in T cell activationQ41682334
Crystal structure of low-molecular-weight protein tyrosine phosphatase from Mycobacterium tuberculosis at 1.9-A resolutionQ42019139
Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.Q42169520
Coupling of Ci-VSP modules requires a combination of structure and electrostatics within the linkerQ42230567
Low molecular weight phosphotyrosine protein phosphatase from PC12 cells. Purification, some properties and expression during neurogenesis in vitro and in vivoQ42442721
PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like proteinQ42444048
A Tyr/Ser protein phosphatase encoded by vaccinia virusQ42621801
Application of neural oscillators to study the effects of walking speed on rhythmic activations at the ankleQ42738452
LMW-PTP is a negative regulator of insulin-mediated mitotic and metabolic signallingQ42795847
The low M(r) protein-tyrosine phosphatase is involved in Rho-mediated cytoskeleton rearrangement after integrin and platelet-derived growth factor stimulation.Q42805494
Purification and characterization of a low-molecular-weight acid phosphatase--a phosphotyrosyl-protein phosphatase from bovine heartQ43409433
P407language of work or nameEnglishQ1860
P304page(s)20
P577publication date2015-01-10
P1433published inFrontiers in PharmacologyQ2681208
P1476titleVoltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research
P478volume6

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cites work (P2860)
Q64910882A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN.
Q36703549Allosteric substrate switching in a voltage-sensing lipid phosphatase
Q41234223Editorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes
Q38968792Hysteresis in voltage-gated channels
Q52655508Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates.

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