ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

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ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M208539200
P8608Fatcat IDrelease_ri3is52spba63emz6wmggptd7m
P3181OpenCitations bibliographic resource ID3907421
P698PubMed publication ID12221107
P5875ResearchGate publication ID11168591

P50authorHelen HobbsQ21433424
Jonathan C. CohenQ24063837
P2093author name stringMing Yi
Guocheng He
Peter Michaely
Sarita Gupta
P2860cites workThe mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sitesQ24301593
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainQ24536014
The structure and function of the beta 2-adaptin appendage domainQ24599597
Peptide-in-groove interactions link target proteins to the beta-propeller of clathrinQ27621166
Further additions to MolScript version 1.4, including reading and contouring of electron-density mapsQ27860974
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pitsQ28142257
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor proteinQ28186061
Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysisQ28207619
beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptinQ28214555
Clathrin and adaptorsQ28280468
Enhanced morphine analgesia in mice lacking beta-arrestin 2Q28504554
A requirement for ankyrin binding to clathrin during coated pit buddingQ28579368
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptorQ29618735
Diversity in protein recognition by PTB domainsQ33801830
Characterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemiaQ33857941
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptorsQ34196707
Clathrin-binding proteins: got a motif? Join the network!Q34328624
Dockers at the crossroadsQ34465504
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteinsQ34568617
Clathrin adaptors really adaptQ34709976
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic miceQ36223333
The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformationQ36256170
Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolismQ39289456
The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformationQ67802007
Characterization of a new form of inherited hypercholesterolemia: familial recessive hypercholesterolemiaQ74598521
P433issue46
P407language of work or nameEnglishQ1860
P921main subjectLow density lipoprotein receptor adaptor protein 1Q6693000
low-density lipoprotein particle receptor bindingQ14890332
AP-2 adaptor complex bindingQ21106401
Low density lipoprotein receptor adaptor protein 1Q21496937
P304page(s)44044-9
P577publication date2002-11-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2
P478volume277

Reverse relations

cites work (P2860)
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Q30430390ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells
Q36992932ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression
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Q36279579Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer
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Q37002668The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation
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Q38980152Using human genetics to discover new therapeutic targets for plasma lipids
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Q44565939Xenopus autosomal recessive hypercholesterolemia protein couples lipoprotein receptors with the AP-2 complex in oocytes and embryos and is required for vitellogenesis

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