Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia

scientific article (publication date: August 2003)

Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M304855200
P953full work available at URLhttp://www.jbc.org/article/S0021925820844020/pdf
https://api.elsevier.com/content/article/PII:S0021925820844020?httpAccept=text/plain
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https://syndication.highwire.org/content/doi/10.1074/jbc.M304855200
P698PubMed publication ID12746448

P50authorHelen HobbsQ21433424
Jonathan C. CohenQ24063837
P2093author name stringWei-Ping Li
Joachim Herz
Robert E. Hammer
Christopher Jones
P2860cites workReeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2Q22010158
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transductionQ22254170
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptorQ24297663
Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursorQ24301384
The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptorQ24304115
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2Q24306476
Molecular mechanisms of autosomal recessive hypercholesterolemiaQ24315900
The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machineryQ24321718
Dual roles for the Dab2 adaptor protein in embryonic development and kidney transportQ24536278
Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnantsQ24564846
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor proteinQ28186061
Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysisQ28207619
Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis ratesQ28209002
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonistQ28286186
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor proteinQ28290411
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsQ28509783
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genesQ29547355
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycolurilQ29618344
Diversity in protein recognition by PTB domainsQ33801830
Characterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemiaQ33857941
The role of the LDL receptor in apolipoprotein B secretionQ33939089
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptorsQ34196707
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptorsQ34263181
PTB or not PTB -- that is the questionQ34575900
Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouseQ35553097
Homologous recombination for gene replacement in mouse cell lines.Q40571100
A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptorQ40801530
Molecular medicine. The cholesterol quartetQ43613380
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structureQ47614862
Sustained somatic gene inactivation by viral transfer of Cre recombinase.Q47948186
Molecular genetics of familial hypercholesterolemia in Spain: Ten novel LDLR mutations and population analysisQ57837960
19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cellsQ70193016
Characterization of a new form of inherited hypercholesterolemia: familial recessive hypercholesterolemiaQ74598521
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
lipoproteinQ28350
Low density lipoprotein receptorQ14872730
Early endosome antigen 1Q14911544
hypercholesterolemiaQ762713
signal transducing adaptor proteinQ5964993
endocytosisQ189814
Low density lipoprotein receptor adaptor protein 1Q21496937
autosomal recessive hypercholesterolemiaQ30988959
P304page(s)29024-30
P577publication date2003-05-13
2003-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleNormal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia
Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia
P478volume278

Reverse relations

cites work (P2860)
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