Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease

scientific article

Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.00463.2016
P932PMC publication ID5206344
P698PubMed publication ID27694217

P50authorChandramohan ChitrajuQ57306408
P2093author name stringLi Wang
Peter M Kang
Olivier Kocher
Ayce Yesilaltay
Monty Krieger
Rinku Pal
Qingen Ke
German A Pihan
Marsha L Penman
P2860cites workARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2Q24306476
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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolismQ24646308
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type IQ24673266
ACTH Regulation of Adrenal SR-B1Q26744697
Dietary manipulation and social isolation alter disease progression in a murine model of coronary heart diseaseQ27313306
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complexQ27618075
Crystal structures of the Dab homology domains of mouse disabled 1 and 2Q27641511
In Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1Q27664175
Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type IQ27667919
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZQ27732927
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Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor proteinQ28186061
Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein MetabolismQ28208721
A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liverQ28214792
Identification of scavenger receptor SR-BI as a high density lipoprotein receptorQ28273182
Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient miceQ28365792
Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor unQ28593554
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart diseaseQ29147547
Recognition of unique carboxyl-terminal motifs by distinct PDZ domainsQ29547580
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein EQ29615236
Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice.Q30528268
Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmissionQ30541733
Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient miceQ30942732
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient miceQ31961261
Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient miceQ33379402
Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cellsQ33713740
Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signalingQ33723587
Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BIQ33767978
Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruptionQ34181941
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptorsQ34263181
Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmAQ34357781
Targeted disruption of the PDZK1 gene by homologous recombinationQ34472849
Excess cholesterol induces mouse egg activation and may cause female infertility.Q34581244
The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity.Q34655581
Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infectionQ34657110
Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fastingQ34737784
The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissuesQ35146324
Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouseQ35163535
PDZ domains-glue and guide.Q35169335
Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusionQ35492308
Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiologyQ35603368
Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout miceQ35776623
Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1.Q36071114
Genome-wide functional annotation of dual-specificity protein- and lipid-binding modules that regulate protein interactionsQ36200455
SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearanceQ36227219
The prevalence and significance of PDZ domain-phosphoinositide interactionsQ36555156
Influence of PDZK1 on lipoprotein metabolism and atherosclerosisQ36708971
Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)Q36779623
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localizationQ36808468
Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).Q37000612
Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid productionQ37190356
Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat.Q37358799
Structures and target recognition modes of PDZ domains: recurring themes and emerging picturesQ38136699
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthaseQ38299352
Comparison of class B scavenger receptors, CD36 and scavenger receptor BI (SR-BI), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptakeQ38330118
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infectionQ39941948
Quantitative multi-gene transcriptional profiling using real-time PCR with a master templateQ40422373
A single point mutation in epsilon-COP results in temperature-sensitive, lethal defects in membrane transport in a Chinese hamster ovary cell mutantQ40939407
Scavenger receptor class B type I as a mediator of cellular cholesterol efflux to lipoproteins and phospholipid acceptorsQ41052382
Metabolism of HDL-cholesteryl ester in the rat, studied with a nonhydrolyzable analog, cholesteryl linoleyl etherQ42259584
Analysis of chimeric receptors shows that multiple distinct functional activities of scavenger receptor, class B, type I (SR-BI), are localized to the extracellular receptor domainQ43585944
Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolismQ43855742
Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.Q43893087
Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient miceQ43893171
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivoQ44090023
Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liverQ44364001
Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse modelsQ45147977
Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor geneQ45877135
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levelsQ45881945
Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 miceQ46557767
Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.Q46734243
HDL cholesterol levels are an important factor for determining the lifespan of erythrocytesQ46786279
Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertilityQ46892860
Therapeutic use of H2O2-responsive anti-oxidant polymer nanoparticles for doxorubicin-induced cardiomyopathyQ46901426
SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cellsQ48010257
Adaptor protein disabled-2 modulates low density lipoprotein receptor synthesis in fibroblasts from patients with autosomal recessive hypercholesterolaemia.Q51795019
Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal glandQ71903440
Cholesteryl ester transfer between high density lipoprotein and phospholipid bilayersQ72431821
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
Scavenger receptor class B, type I-mediated [3H]cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptorQ72992440
Regulation of adrenal scavenger receptor-BI expression by ACTH and cellular cholesterol poolsQ73045943
Characterization of a new form of inherited hypercholesterolemia: familial recessive hypercholesterolemiaQ74598521
PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or functionQ79988027
Genetic variant of the scavenger receptor BI in humansQ83176299
The effects of diet on occlusive coronary artery atherosclerosis and myocardial infarction in scavenger receptor class B, type 1/low-density lipoprotein receptor double knockout miceQ85294487
P433issue6
P921main subjecthypercholesterolemiaQ762713
P304page(s)H1392-H1408
P577publication date2016-09-30
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleCarboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease
P478volume311