Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)

scientific article published on 12 March 2013

Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs) is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M112.437368
P932PMC publication ID3630890
P698PubMed publication ID23482569
P5875ResearchGate publication ID236038895

P50authorFredric B KraemerQ57026392
Wen-jun ShenQ42605986
P2093author name stringZhonghua Zhang
C Chris Yun
Catherine H Berlot
Jie Hu
Salman Azhar
Zhigang Hu
P2860cites workA novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptorQ24294304
The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminusQ24300981
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signalingQ24303571
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchangeQ24310009
NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrinQ24315976
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteinsQ24316901
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activationQ24563311
cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory proteinQ24569613
Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchangerQ24629554
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type IQ24673266
Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin familyQ24678695
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factorsQ26863645
Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunityQ27015870
Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applicationsQ27632278
The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domainsQ28118246
Assembly of asparagine-linked oligosaccharidesQ28131690
Interaction of the type IIa Na/Pi cotransporter with PDZ proteinsQ28139020
Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2Q28140591
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activityQ28142263
The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulationQ28206397
Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein MetabolismQ28208721
PDZ domains: structural modules for protein complex assemblyQ28210680
Identification of scavenger receptor SR-BI as a high density lipoprotein receptorQ28273182
Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bileQ28507887
Hormonal regulation of adrenal microvillar channel formationQ28567185
Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalinQ28582784
ERM proteins and merlin: integrators at the cell cortexQ29619893
PDZ Domain Proteins: Plug and Play!Q30164767
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient miceQ31961261
Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroidogenic cell modelQ32033476
NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.Q33289407
Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cellsQ33345889
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in miceQ33409811
Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cellsQ33713740
Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteinsQ33762954
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormonesQ33934310
Apical Scaffolding Protein NHERF2 Modulates the Localization of Alternatively Spliced Plasma Membrane Ca2+ Pump 2B Variants in Polarized Epithelial CellsQ34181530
Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.Q34291387
MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cellsQ34304540
Cholesterol uptake by the 'selective' pathway of ovarian granulosa cells: early intracellular eventsQ71831178
Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal glandQ71903440
The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesisQ72868844
Expression and microvillar localization of scavenger receptor class B, type I (SR-BI) and selective cholesteryl ester uptake in Leydig cells from rat testisQ73520309
Estrogen receptor regulation of the Na+/H+ exchange regulatory factorQ77932795
Genetic variant of the scavenger receptor BI in humansQ83176299
Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidasesQ34432942
Morphological evidence that high density lipoproteins are not internalized by steroid-producing cells during in situ organ perfusionQ34617491
Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four PDZ domains of PDZK1.Q34657849
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activityQ34782190
Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesisQ34922440
The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissuesQ35146324
Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connectionQ35212913
Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomainsQ35266868
Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalizationQ36098021
NHERF family and NHE3 regulationQ36132944
The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity.Q36349480
The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.Q36387923
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localizationQ36808468
Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonadQ37348207
Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat.Q37358799
The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transportQ37524286
Fine-tuning of GPCR activity by receptor-interacting proteinsQ37638132
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolismQ37899345
Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds. Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5.Q38314411
Comparison of class B scavenger receptors, CD36 and scavenger receptor BI (SR-BI), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptakeQ38330118
The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domainQ38332891
Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptakeQ38361053
Na+/H+ Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 HeterodimerQ39043299
Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.Q40027003
Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI.Q40530556
Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targetingQ40557360
Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transportQ40682227
Angiotensin II promotes selective uptake of high density lipoprotein cholesterol esters in bovine adrenal glomerulosa and human adrenocortical carcinoma cells through induction of scavenger receptor class B type I.Q40779463
Oligomerization of NHERF-1 and NHERF-2 PDZ domains: differential regulation by association with receptor carboxyl-termini and by phosphorylationQ40792096
The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.Q40999069
Human granulosa cells use high density lipoprotein cholesterol for steroidogenesisQ41723020
A nonendocytotic mechanism for the selective uptake of high density lipoprotein-associated cholesterol esters.Q41914111
Selective uptake of high-density lipoprotein-associated cholesteryl esters by human hepatocytes in primary cultureQ41935392
Utilization of cholesterol-rich lipoproteins by perfused rat adrenalsQ42193781
The selective pathway and a high-density lipoprotein receptor (SR-BI) in ovarian granulosa cells of the mouseQ42467884
Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liverQ44364001
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levelsQ45881945
Expression and microvillar localization of scavenger receptor, class B, type I (a high density lipoprotein receptor) in luteinized and hormone-desensitized rat ovarian modelsQ46200888
Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.Q46535745
LH/hCG-stimulated androgen production and selective HDL-cholesterol transport are inhibited by a dominant-negative CREB construct in primary cultures of rat theca-interstitial cellsQ46757806
NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors.Q51796458
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)11416-11435
P577publication date2013-03-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleRegulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)
P478volume288

Reverse relations

cites work (P2860)
Q26744697ACTH Regulation of Adrenal SR-B1
Q52606603Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells.
Q33435708Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease
Q36987523Cell-Specific Polymorphism and Hormonal Regulation of DNA Methylation in Scavenger Receptor Class B, Type I.
Q41847058Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver
Q37708374Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis
Q35035952Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland
Q35186664Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1.
Q33894679New developments in selective cholesteryl ester uptake
Q50123852Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway
Q38293434Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational
Q42512668Regulation of adrenal and ovarian steroidogenesis by miR-132.
Q36688121SNARE-Mediated Cholesterol Movement to Mitochondria Supports Steroidogenesis in Rodent Cells
Q46215753SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux
Q57115959Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function
Q53742308Shear stress regulates endothelial cell function through SRB1-eNOS signaling pathway.

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