Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger

scientific article

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI117903
P3181OpenCitations bibliographic resource ID2433532
P932PMC publication ID295815
P698PubMed publication ID7738182

P2093author name stringY Wang
S Shenolikar
E J Weinman
D Steplock
P2860cites workIsolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactorQ33904680
Regulation of the renal Na+-H+ exchanger by protein phosphorylationQ38300529
Regulation of the renal brush border membrane Na(+)-H+ exchangerQ40852812
Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line.Q41509579
Regulation of integrin gene expression by substrate adherenceQ41593842
Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinaseQ42493778
Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM.Q43703855
Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase.Q46493439
The mercury-sensitive residue at cysteine 189 in the CHIP28 water channelQ49155866
Parathyroid hormone and dibutyryl cAMP inhibit Na+/H+ exchange in renal brush border vesiclesQ50917649
Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinaseQ68459009
Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchangerQ69826278
Relationship among parathyroid hormone, cAMP, and calcium on proximal tubule sodium transportQ70099545
cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranesQ70164212
Use of stock solutions to simplify mRNA quantitation by reverse transcription--PCR assaysQ72086338
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2143-9
P577publication date1995-05-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleCharacterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger
P478volume95

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cites work (P2860)
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Q28217140Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate
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Q28212817Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2
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Q24678695Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
Q42446313Identification of sites required for down-regulation of Na+/H+ exchanger NHE3 activity by cAMP-dependent protein kinase. phosphorylation-dependent and -independent mechanisms
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Q28184044Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells
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Q35602856Molecular biology of major components of chloride cells
Q28593876Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor
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Q40829201N-terminal PDZ domain is required for NHERF dimerization
Q35746077NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas
Q24320465NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
Q24315976NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin
Q28566881NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli
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Q36059428NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.
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Q28569226NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function
Q28594196NHERF-1 is required for renal adaptation to a low-phosphate diet
Q28586939NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes
Q49894086NHERF1 Between Promises and Hopes: Overview on Cancer and Prospective Openings
Q37631384NHERF1 Enhances Cisplatin Sensitivity in Human Cervical Cancer Cells
Q39452623NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production
Q37246058NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia
Q36288731NHERF1/EBP50 controls lactation by establishing basal membrane polarity complexes with prolactin receptor
Q24294023NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
Q34096013NHERF1/EBP50 in Breast Cancer: Clinical Perspectives
Q36910196NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells
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Q31955806NHERF: targeting and trafficking membrane proteins
Q34391269NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane
Q37412617Na+-H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST.
Q39043299Na+/H+ Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 Heterodimer
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Q24563377PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane
Q35913827PDZ interactions and proximal tubular phosphate reabsorption
Q36135269PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli
Q35980372PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes
Q34154837PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters.
Q35907048PTH-mediated inhibition of the renal transport of phosphate
Q41308389Parathyroid Hormone and Parathyroid Hormone-related Peptide Inhibit the Apical Na+/H+ Exchanger NHE-3 Isoform in Renal Cells (OK) via a Dual Signaling Cascade Involving Protein Kinase A and C
Q40443094Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes.
Q28272686Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)
Q43726481Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase
Q24294974Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets
Q58611871Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)
Q34467912Physiology, phylogeny, and functions of the TRP superfamily of cation channels
Q24292155Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes
Q24515074Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity
Q28577406Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea
Q33774792Posttranscriptional regulation of the proximal tubule NaPi-II transporter in response to PTH and dietary P(i).
Q28214893Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor
Q40426090Protein kinase C regulates the phosphorylation and oligomerization of ERM binding phosphoprotein 50.
Q33712466Protein modules as organizers of membrane structure
Q36178341Protein/protein interactions (PDZ) in proximal tubules
Q35135447Proteins modulating TRP channel function
Q34563763Proximal tubular handling of phosphate: A molecular perspective
Q28140211Proximal tubular phosphate reabsorption: molecular mechanisms
Q26863645Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors
Q28218864Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)
Q33536481Regulation of cortical structure by the ezrin-radixin-moesin protein family
Q34662162Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction
Q36779623Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)
Q36629251Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells
Q41099053Regulation of the Epithelial Brush Border Na+/H+ Exchanger Isoform 3 Stably Expressed in Fibroblasts by Fibroblast Growth Factor and Phorbol Esters Is Not through Changes in Phosphorylation of the Exchanger
Q28579273Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex
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Q34134874Role of endocytosis in mediating downregulation of G-protein-coupled receptors
Q39076960Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.
Q28215471SLC26A3 mutations in congenital chloride diarrhea
Q28282331Shank2 associates with and regulates Na+/H+ exchanger 3
Q52647032Shank2 mutant mice display a hypersecretory response to cholera toxin.
Q34019706Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA.
Q33748611Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity
Q28645766Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control
Q33178506Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule
Q47983634Specific expression of ezrin, a cytoskeletal-membrane linker protein, in a subset of chick retinotectal and sensory projections
Q91666333Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle
Q27631209Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator
Q27638205Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors
Q37382049Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
Q28510488Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting
Q33831383Targeting of membrane transporters in renal epithelia: when cell biology meets physiology
Q36538416Temporal and spatial regulation of ezrin-radixin-moesin-binding phosphoprotein-50-kDa (EBP50) during embryo implantation in mouse uterus
Q28140731The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells
Q35555968The ERM protein, ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection
Q27314709The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization
Q24338409The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity
Q34397161The TRP superfamily of cation channels
Q24310009The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
Q47859501The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule
Q39343398The detection of EBP50 expression using quantum dot immunohistochemistry in pancreatic cancer tissue and down-regulated EBP50 effect on PC-2 cells
Q36518490The emerging role of PDZ adapter proteins for regulation of intestinal ion transport
Q36156821The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation.
Q24300981The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus
Q28576784The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli
Q37433460The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity
Q40999069The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.
Q36149219The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a.
Q24302333The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner
Q37270609The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics.
Q30491433The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton
Q30478396Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions
Q34286270Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions
Q40490834Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor
Q24683312Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50
Q33871626cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor
Q24569613cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein
Q28255347kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins

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