The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues

scientific article

The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1210/ER.2001-0037
P698PubMed publication ID12788804
P5875ResearchGate publication ID10723273

P2093author name stringMonty Krieger
Helena E Miettinen
Attilio Rigotti
P2860cites workCholesteryl ester is transported from caveolae to internal membranes as part of a caveolin-annexin II lipid-protein complexQ40762364
P433issue3
P304page(s)357-387
P577publication date2003-06-01
P1433published inEndocrine ReviewsQ3054007
P1476titleThe role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues
P478volume24

Reverse relations

cites work (P2860)
Q4485564817β-Estradiol regulates scavenger receptor class BI gene expression via protein kinase C in vascular endothelial cells.
Q37665457A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis
Q38874507A new trichostatin analog from Streptomyces sp. CPCC 203909.
Q26744697ACTH Regulation of Adrenal SR-B1
Q33997963ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level
Q34737784Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting
Q37149894Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition.
Q60921133Alcohol Pattern Consumption Differently Affects the Efficiency of Macrophage Reverse Cholesterol Transport in Vivo
Q27487872Analysis of a conserved RGE/RGD motif in HCV E2 in mediating entry
Q38639118Animal models of coronary heart disease.
Q28511491ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36
Q50420416Association of rs5888 SNP in SCARB1 gene with coronary artery disease : Study of a Han Chinese population.
Q35611085Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake
Q36616904Biomimetic, synthetic HDL nanostructures for lymphoma
Q57241788Blocking HCV entry as potential antiviral therapy
Q33435708Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease
Q33934310Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Q36405130Cellular cholesterol homeostasis in vascular endothelial cells
Q34921017Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1
Q46266055Characterization of cholesterol metabolism in Sertoli cells and spermatogenesis (Review).
Q39232151Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein
Q34019174Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins
Q37095012Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells
Q36501289Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis
Q37377173Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2
Q90725689Cholesterol: A Gatekeeper of Male Fertility?
Q39374915Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation
Q51469653Clinical impact of scavenger receptor class B type I gene polymorphisms on human female fertility.
Q43583442Clusterin facilitates in vivo clearance of extracellular misfolded proteins
Q40195068Consequences of over-expression of rat Scavenger Receptor, SR-BI, in an adrenal cell model
Q43202367Contributions of a disulfide bond and a reduced cysteine side chain to the intrinsic activity of the high-density lipoprotein receptor SR-BI.
Q37222682Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CE
Q26830841Critical insights into cardiovascular disease from basic research on the oxidation of phospholipids: the γ-hydroxyalkenal phospholipid hypothesis
Q44854863Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide
Q33899448Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI.
Q45079531Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.
Q40390167Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux
Q34467689Differential effects of testosterone, dihydrotestosterone and estradiol on carotenoid deposition in an avian sexually selected signal.
Q40530556Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI.
Q34806027Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet
Q28582095Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues
Q50299805Disassembly of SR-BI-bound spherical HDL
Q35626125Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake
Q27485638Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding
Q38733357EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.
Q34221799Early steps in steroidogenesis: intracellular cholesterol trafficking
Q54319458Effect of the metabolic environment at key stages of follicle development in cattle: focus on steroid biosynthesis.
Q57375119Effects of amino acid substitutions at glycine 420 on SR-BI cholesterol transport function
Q36335152Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice
Q35694689Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals
Q90503839Even Cancer Cells Watch Their Cholesterol!
Q34581244Excess cholesterol induces mouse egg activation and may cause female infertility.
Q35134086Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity
Q88605247Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states
Q38376197Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis
Q40543539Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat.
Q42002226Expression pattern and tissue localization of the class B scavenger receptor BmSCRBQ4 in Bombyx mori
Q30528268Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice.
Q92466281Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model
Q37022485Fluorescence techniques using dehydroergosterol to study cholesterol trafficking
Q37271503Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women
Q44827064Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester.
Q34998020Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport
Q38195221HDL hypothesis: where do we stand now?
Q36387151HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains
Q34812700Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis
Q36946317Hepatitis C virus entry
Q35182834Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion
Q34496687High Density Lipoprotein Nanoparticles Deliver RNAi to Endothelial Cells to Inhibit Angiogenesis.
Q44730641High density lipoprotein uptake by scavenger receptor SR-BII.
Q37584875High-density lipoprotein metabolism and the human embryo.
Q36726706Hitch-hiking between cells on lipoprotein particles.
Q35533422Human FABP1 T94A variant enhances cholesterol uptake
Q35080215Human endothelial progenitor cells internalize high-density lipoprotein
Q28292554Human ocular carotenoid-binding proteins
Q48486252Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia
Q45292359Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors
Q38941086Icariin inhibits foam cell formation by down-regulating the expression of CD36 and up-regulating the expression of SR-BI.
Q37240487Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease
Q27667919Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I
Q37330041Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
Q55340190Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages.
Q34735178Impact of genetic variants in human scavenger receptor class B type I (SCARB1) on plasma lipid traits.
Q26864485Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization
Q38304734Impact of vitamin A on high-density lipoprotein-cholesterol and scavenger receptor class BI in the obese rat.
Q38501225Implications of scavenger receptors in the safe development of nanotherapeutics
Q27664175In Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1
Q46897446Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients
Q35811972Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport
Q36708971Influence of PDZK1 on lipoprotein metabolism and atherosclerosis
Q30857888Insulin and angiotensin II induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes
Q40306384Involvement of mitogen-activated protein kinases in class B scavenger receptor type I-induced phagocytosis of apoptotic cells
Q28585335Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression
Q35758221LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
Q46757806LH/hCG-stimulated androgen production and selective HDL-cholesterol transport are inhibited by a dominant-negative CREB construct in primary cultures of rat theca-interstitial cells
Q35754362Lipoprotein kinetics in the metabolic syndrome: pathophysiological and therapeutic lessons from stable isotope studies
Q36272611Liposome opsonization
Q30942732Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice
Q37404695Lung vitamin E transport processes are affected by both age and environmental oxidants in mice
Q30693939Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease
Q34132240Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin.
Q52927684MACULAR PIGMENT DISTRIBUTION RESPONSES TO HIGH-DOSE ZEAXANTHIN SUPPLEMENTATION IN PATIENTS WITH MACULAR TELANGIECTASIA TYPE 2.
Q36520311Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
Q51794680Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.
Q35693911Metabolism of carotenoids and retinoids related to vision
Q37650114Micro-RNAs and High-Density Lipoprotein Metabolism.
Q37331060MicroRNA-122: a new player in the negative regulation of LH receptor expression by the LH receptor mRNA binding protein (LRBP).
Q34304540MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells
Q27021139Molecular mechanisms of cellular cholesterol efflux
Q34726050Negatively cooperative binding of high-density lipoprotein to the HDL receptor SR-BI
Q33894679New developments in selective cholesteryl ester uptake
Q35157201New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
Q36145366Non-vesicular sterol transport in cells
Q37000612Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).
Q34657849Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four PDZ domains of PDZK1.
Q33490601Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein
Q33580624Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease
Q36808468Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization
Q33743839Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages
Q93052161Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
Q35575019Phaleria macrocarpa Boerl. (Thymelaeaceae) leaves increase SR-BI expression and reduce cholesterol levels in rats fed a high cholesterol diet.
Q35093667Physiological Role of a Multigrain Diet in Metabolic Regulations of Lipid and Antioxidant Profiles in Hypercholesteremic Rats: Multigrain diet in hyperlipemia
Q36032978Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo
Q58751295Primary genetic disorders affecting high density lipoprotein (HDL)
Q35944538Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice
Q35774863Purification and characterisation of the extracellular cholesterol oxidase enzyme from Enterococcus hirae
Q40570776Quality control in the apoA-I secretory pathway: deletion of apoA-I helix 6 leads to the formation of cytosolic phospholipid inclusions.
Q29147547Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Q34016103Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1.
Q36779623Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)
Q34397435Regulation of platelet function by class B scavenger receptors in hyperlipidemia
Q28382976Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke
Q46069993Retracted: Advances in the physiological and pathological implications of cholesterol.
Q27490535Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants
Q33767978Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI
Q47377607Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering
Q33945072Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT.
Q36691137SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner
Q24297669SIRT1 deacetylates and positively regulates the nuclear receptor LXR
Q36018198SR-BI and HDL cholesteryl ester metabolism
Q35919260SR-BI and protein-protein interactions in hepatic high density lipoprotein metabolism.
Q36227219SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance
Q92627442Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas
Q57115959Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function
Q35215415Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia
Q24299462Scavenger receptor SR-BI in macrophage lipid metabolism
Q34375724Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model
Q24304399Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure
Q34246570Scavenger receptor class B type I: a multifunctional receptor
Q34622857Scavenger receptor class B, type I (Scarb1) deficiency promotes osteoblastogenesis but stunts terminal osteocyte differentiation
Q38127564Scavenger receptors in homeostasis and immunity
Q38859778Secretin, at the hub of water-salt homeostasis
Q39783113Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters.
Q38221447Steroidogenesis-adrenal cell signal transduction
Q57072613Sterol Metabolism and Transport in Atherosclerosis and Cancer
Q36456339Structural identification and cardiovascular activities of oxidized phospholipids.
Q24338905Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36
Q28208721Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism
Q34763617Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles
Q38615654Targeting HCV entry for development of therapeutics
Q28070244Targeting the SR-B1 Receptor as a Gateway for Cancer Therapy and Imaging
Q91639477The SR-B1 Receptor as a Potential Target for Treating Glioblastoma
Q33719403The SR-BI partner PDZK1 facilitates hepatitis C virus entry.
Q42788265The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic lesions in apoE knockout mice
Q43152103The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
Q39455897The effect of statins on the organs: similar or contradictory?
Q34178582The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors
Q33379402Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice
Q57021147Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure
Q54992860Water-Soluble Fish Protein Intake Led to Lower Serum and Liver Cholesterol Concentrations in Obese Zucker fa/fa Rats.
Q34248289microRNAs and HDL life cycle.
Q33508828rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration

Search more.