Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex

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Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex is …
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scholarly articleQ13442814

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P819ADS bibcode1999Sci...284..812H
P356DOI10.1126/SCIENCE.284.5415.812
P8608Fatcat IDrelease_i6ee6oeohbdcdaorquf3zou5pm
P3181OpenCitations bibliographic resource ID40422
P698PubMed publication ID10221915
P5875ResearchGate publication ID13076371

P2093author name stringW A Lim
D S Bredt
K E Prehoda
B J Hillier
K S Christopherson
P433issue5415
P407language of work or nameEnglishQ1860
P304page(s)812-5
P577publication date1999-04-30
P1433published inScienceQ192864
P1476titleUnexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
P478volume284

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cites work (P2860)
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Q28587855Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy
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Q24300217Structure of the membrane-tethering GRASP domain reveals a unique PDZ ligand interaction that mediates Golgi biogenesis
Q27654546Structure of the second PDZ domain from human zonula occludens 2
Q38136699Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures
Q49076902Subcellular localization of neuronal nitric oxide synthase in rat small intestine
Q36488231Subcellular targeting and trafficking of nitric oxide synthases
Q27640613Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95
Q34995237Synthetic protein scaffolds provide modular control over metabolic flux.
Q88782959Syntrophin binds directly to multiple spectrin-like repeats in dystrophin and mediates binding of nNOS to repeats 16-17
Q38069443Syntrophin proteins as Santa Claus: role(s) in cell signal transduction
Q57039821Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy
Q40233858TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes.
Q27642341Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding
Q101574532Targeting receptor complexes: a new dimension in drug discovery
Q30159752Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels
Q35909871The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins
Q33952347The PDZ domain of the SpoIVB serine peptidase facilitates multiple functions
Q28506494The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells
Q27636859The PDZ1 domain of SAP90. Characterization of structure and binding
Q24538474The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions
Q22254751The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Q39214025The characterization of the nuclear dynamics of syntenin-2, a PIP2 binding PDZ protein
Q98196738The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission
Q38019679The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains
Q36518490The emerging role of PDZ adapter proteins for regulation of intestinal ion transport
Q34386676The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain.
Q34478082The light chains of microtubule-associated proteins MAP1A and MAP1B interact with α1-syntrophin in the central and peripheral nervous system
Q54287344The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor.
Q28115307The multiple-specificity landscape of modular peptide recognition domains
Q35834674The muscular dystrophies: from genes to therapies
Q28582443The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death
Q35054394The origin of CDR H3 structural diversity
Q24306862The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization
Q24291771The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I
Q28484777The role of flexibility and conformational selection in the binding promiscuity of PDZ domains
Q37395713The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.
Q47070117The second PDZ domain of INAD is a type I domain involved in binding to eye protein kinase C. Mutational analysis and naturally occurring variants
Q22254181The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL
Q36943279Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study
Q28583323Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein
Q36317205Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration
Q40044008Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling
Q40556555Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust
Q48229749Translational readthrough generates new astrocyte AQP4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport.
Q42982201Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication
Q51124608Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain.
Q24673218U2AF homology motifs: protein recognition in the RRM world
Q34134919USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses
Q41195544Understanding the effect of alternative splicing in the folding and function of the second PDZ from protein tyrosine phosphatase-BL.
Q36168383Understanding the role of phosphorylation in the binding mechanism of a PDZ domain
Q48179080Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models.
Q27659324Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms
Q40323844YaeL proteolysis of RseA is controlled by the PDZ domain of YaeL and a Gln-rich region of RseA.
Q56890049ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability
Q44159120Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
Q48085924gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins
Q30168747hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions
Q37272766modPDZpep: a web resource for structure based analysis of human PDZ-mediated interaction networks
Q36321159{alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner
Q36535303α2 and α3 helices of dystrophin R16 and R17 frame a microdomain in the α1 helix of dystrophin R17 for neuronal NOS binding
Q39252573β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

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