Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1

scientific article

Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2013.04.001
P932PMC publication ID4058784
P698PubMed publication ID23583913

P50authorDavid CowburnQ41044138
P2093author name stringZimei Bu
Shibani Bhattacharya
Natalia Orlova
Jahan Ali Khajeh
Jeong Ho Ju
P2860cites workEnergetics of peptide recognition by the second PDZ domain of human protein tyrosine phosphatase 1EQ24293758
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligandsQ24294023
The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent mannerQ24302333
Ligand-dependent dynamics and intramolecular signaling in a PDZ domainQ24303478
A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95Q24304455
The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eyeQ24307816
NHERF1 mutations and responsiveness of renal parathyroid hormoneQ24311831
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteinsQ24316901
Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1Q24337436
The relation between the divergence of sequence and structure in proteinsQ24531519
Activation of nanoscale allosteric protein domain motion revealed by neutron spin echo spectroscopyQ24606859
Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin familyQ24678695
Structural and energetic basis of allosteryQ26825355
Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factorsQ26863645
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complexQ27618075
Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulatorQ27631209
Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domainsQ27631751
Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptorsQ27638205
Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BLQ27638244
Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95Q27640613
Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineeringQ27643278
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensionsQ27644225
Creating conformational entropy by increasing interdomain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95Q27653107
A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formationQ27658822
Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1EQ27664457
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27Q27667305
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZQ27732927
Automated NOESY interpretation with ambiguous distance restraints: the refined NMR solution structure of the pleckstrin homology domain from beta-spectrinQ27739804
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxationQ27860508
Using NMRView to visualize and analyze the NMR spectra of macromoleculesQ27860567
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Torsion angle dynamics for NMR structure calculation with the new program DYANAQ27860808
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNAQ28119124
The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membraneQ28138284
Mechanism and role of PDZ domains in signaling complex assemblyQ28190934
Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1Q28251491
Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)Q28272686
Recognition of unique carboxyl-terminal motifs by distinct PDZ domainsQ29547580
Multiple sequence alignment using ClustalW and ClustalXQ29547698
Evolutionarily conserved pathways of energetic connectivity in protein familiesQ29615037
Backbone dynamics of Escherichia coli ribonuclease HI: correlations with structure and function in an active enzymeQ29616524
Beyond the binding site: the role of the β₂-β₃ loop and extra-domain structures in PDZ domainsQ30010158
The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recyclingQ41893473
Interactions outside the boundaries of the canonical binding groove of a PDZ domain influence ligand binding.Q45369369
NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95.Q46028694
The Multi-PDZ domain protein MUPP1 as a lipid raft-associated scaffolding protein controlling the acrosome reaction in mammalian spermatozoaQ46982688
The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant moleculeQ47859501
Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding.Q55046212
Scaffold proteins as dynamic switchesQ58035261
Mapping of the spectral densities of N-H bond motions in eglin c using heteronuclear relaxation experimentsQ67549863
Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assemblyQ80573069
Protein function and allostery: a dynamic relationshipQ83273837
Spectral density function mapping using 15N relaxation data exclusivelyQ30193137
The linkage between protein folding and functional cooperativity: two sides of the same coin?Q30330262
Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility.Q30384111
Extensions of PDZ domains as important structural and functional elementsQ30398142
Conformational dynamics and thermodynamics of protein-ligand binding studied by NMR relaxationQ30414491
The binding of the PDZ tandem of syntenin to target proteins.Q30439757
Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain.Q30616861
Change in allosteric network affects binding affinities of PDZ domains: analysis through perturbation response scanningQ31036350
NHERF: targeting and trafficking membrane proteinsQ31955806
A specificity map for the PDZ domain familyQ33373127
A sequential binding mechanism in a PDZ domain.Q33460634
Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cellsQ33571668
A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organizationQ33818470
Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolutionQ34162330
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKAQ34468233
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interactionQ34662162
Analysis of CFTR interactome in the macromolecular complexesQ35228705
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteinsQ35850129
Structural basis for NHERF1 PDZ domain bindingQ35881936
Is allostery an intrinsic property of all dynamic proteins?Q35894622
Regulation of ion transport by the NHERF family of PDZ proteinsQ35952169
Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transportQ36097909
PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilliQ36135269
The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.Q36387923
Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factorQ36662166
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic densityQ37372485
Hidden dynamic allostery in a PDZ domain.Q37416575
The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transportQ37524286
Structural diversity of PDZ-lipid interactionsQ37679068
The regulation of renal phosphate transportQ37853251
Plasticity of PDZ domains in ligand recognition and signaling.Q38009191
The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domainsQ38019679
Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulatorQ40380183
PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulatorQ40712140
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)2509-28
P577publication date2013-07-24
P1433published inJournal of Molecular BiologyQ925779
P1476titleLigand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1
P478volume425

Reverse relations

cites work (P2860)
Q46368190A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction.
Q28548258Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1
Q51101460Controllable Activation of Nanoscale Dynamics in a Disordered Protein Alters Binding Kinetics.
Q41193412Different conformational dynamics of PDZ1 and PDZ2 in full-length EBP50 analyzed by hydrogen/deuterium exchange mass spectrometry.
Q89517063In vivo crystals reveal critical features of the interaction between cystic fibrosis transmembrane conductance regulator (CFTR) and the PDZ2 domain of Na+/H+ exchange cofactor NHERF1
Q38779098Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling
Q35628688Nanoscale protein domain motion and long-range allostery in signaling proteins- a view from neutron spin echo sprectroscopy
Q40777350On the analysis and comparison of conformer-specific essential dynamics upon ligand binding to a protein
Q28255119Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering
Q30364686Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.
Q35235024Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction.
Q27680153Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1
Q87893432Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling
Q38136699Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures
Q41871958Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove
Q91052598The CYSMA web server: An example of integrative tool for in silico analysis of missense variants identified in Mendelian disorders
Q37270609The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics.

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