Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments

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Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...854581I
P356DOI10.1371/JOURNAL.PONE.0054581
P932PMC publication ID3563628
P698PubMed publication ID23390500
P5875ResearchGate publication ID235416873

P50authorStephane BetziQ55117889
Nicolas LenfantQ55137620
Ylva IvarssonQ55299924
Xavier MorelliQ37376632
Jolanta PolanowskaQ43118120
Jean-Paul BorgQ49224201
P2093author name stringPascale Zimmermann
Jérôme Reboul
Anna Maria Wawrzyniak
Driss Chiheb
Elke Vermeiren
Frédérique Lembo
Rudra Kashyap
P2860cites workCharacterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilamentsQ24290826
The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1Q24301988
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinasesQ24303438
Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cellsQ24314419
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functionsQ24314508
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartmentsQ24316079
EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motifQ24320229
Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1Q24337436
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cellsQ24599234
Scaffold proteins: hubs for controlling the flow of cellular informationQ24611517
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral buddingQ24645971
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complexQ27618075
Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranesQ27648706
PDZ domains of Par-3 as potential phosphoinositide signaling integratorsQ27649319
Structural basis for the regulated protease and chaperone function of DegPQ27650659
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domainsQ27934605
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphataseQ28118769
The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor proteinQ28198177
ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctionsQ28251954
Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinasesQ28276144
Translation of the phosphoinositide code by PI effectorsQ28285651
Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylationQ50335975
Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain.Q51124608
Nucleolar localization of protein B23 (37/5.1) by immunocytochemical techniquesQ70154916
Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicingQ74520175
Phosphoinositide synthesis and degradation in isolated rat liver peroxisomesQ79256584
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95Q28290055
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)Q28640016
Extensions of PDZ domains as important structural and functional elementsQ30398142
Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactionsQ30476030
Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Q33636764
A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding.Q33756741
Structure of the split PH domain and distinct lipid-binding properties of the PH-PDZ supramodule of alpha-syntrophinQ34324850
Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction networkQ34516482
Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transitionQ34968585
Phosphoinositide signaling: new tools and insights.Q35078016
Nuclear lipid signallingQ35120151
Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulinQ35639837
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cellsQ36118986
Genome-wide functional annotation of dual-specificity protein- and lipid-binding modules that regulate protein interactionsQ36200455
A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactionsQ36235244
Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide poolsQ36255578
Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteinsQ36256280
Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomesQ36530215
Determining selectivity of phosphoinositide-binding domainsQ36531104
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identityQ36822749
Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafishQ36851334
Plasticity of PDZ domains in ligand recognition and signaling.Q38009191
The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domainsQ38019679
The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domainQ39794504
The tandem PDZ domains of syntenin promote cell invasionQ40142496
Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6.Q40378604
PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membraneQ40721942
Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion.Q41064785
The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesisQ41859255
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.Q41966849
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imagingQ42093938
Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytesQ47761769
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domainsQ47895700
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)e54581
P577publication date2013-02-04
P1433published inPLOS OneQ564954
P1476titlePrevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments
P478volume8

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cites work (P2860)
Q39006035Biochemical Large-Scale Interaction Analysis of Murine Olfactory Receptors and Associated Signaling Proteins with Post-Synaptic Density 95, Drosophila Discs Large, Zona-Occludens 1 (PDZ) Domains
Q28116457Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
Q28115000Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes
Q26778952Membrane Binding and Modulation of the PDZ Domain of PICK1
Q91913292Specificity in PDZ-peptide interaction networks: Computational analysis and review
Q87893432Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling
Q39014592Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2.
Q39145697The human PDZome: a gateway to PSD95-Disc large-zonula occludens (PDZ)-mediated functions
Q57134574Three-dimensional Cellular Raman Analysis: Evidence of Highly Ordered Lipids Within Cell Nuclei

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