AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response.

scientific article

AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBADIS.2014.07.002
P932PMC publication ID6408939
P698PubMed publication ID25016145
P5875ResearchGate publication ID263860401

P2093author name stringJiyeon Lee
Hongliang Li
Chaoyong He
Zhonglin Xie
Ming-Hui Zou
Qing Min
Changhan Ouyang
P2860cites workDissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetesQ36720530
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Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acidsQ37575390
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The interplay between autophagy and apoptosis in the diabetic heartQ38186863
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitusQ38319698
Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2.Q39965365
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
Clenbuterol inhibits SREBP-1c expression by activating CREB1.Q40099558
7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4BQ42044570
Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats.Q44286316
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathwayQ44297061
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.Q46890287
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesityQ80146743
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR actionQ24302566
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveQ24306328
Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesQ24656627
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signalingQ27008029
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
TSC2 mediates cellular energy response to control cell growth and survivalQ27860970
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingQ28131740
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob miceQ28144106
The AMP-activated protein kinase cascade--a unifying system for energy controlQ28239257
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysQ28242180
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient statusQ28245724
Upstream and downstream of mTORQ28277365
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stressQ28570993
Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liverQ28577788
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Coping with stress: eIF2 kinases and translational controlQ29619787
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivoQ33675689
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.Q33821960
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in agingQ33912952
Management of cellular energy by the AMP-activated protein kinase systemQ34209246
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 miceQ35043474
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.Q35213694
Acute exercise activates AMPK and eNOS in the mouse aortaQ35395455
AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathyQ35534097
Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistanceQ35922894
Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese miceQ36454186
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.Q36497296
P433issue9
P921main subjectendoplasmic reticulumQ79927
P1104number of pages11
P304page(s)1844-1854
P577publication date2014-07-10
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleAMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response
P478volume1842

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