SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (scientific article (publication date: May 2002))

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Q42257091	Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation
Q33417684	Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway
Q24685842	Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles
Q36086300	Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice
Q36776696	Cholesterol: from feeding to gene regulation
Q28504868	Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression
Q89658772	Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish
Q45928058	Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance.
Q34904117	Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats.
Q45261151	Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs
Q36514288	Chronic exposure to low-dose arsenic modulates lipogenic gene expression in mice
Q38323357	Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice
Q34559843	Chronic social defeat stress disrupts regulation of lipid synthesis
Q64101969	Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites
Q37726319	Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats
Q42800723	Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors
Q92882095	Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold
Q101226470	Circulating expression of Hsa_circRNA_102893 contributes to early gestational diabetes mellitus detection
Q58611996	Circulating miRNA measurements are reflective of cholesterol-based changes in rainbow trout (Oncorhynchus mykiss)
Q39094141	Cirsium brevicaule A. GRAY leaf inhibits adipogenesis in 3T3-L1 cells and C57BL/6 mice
Q34668864	Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes
Q37420502	Clinical Significance of Determining Plasma MicroRNA33b in Type 2 Diabetic Patients with Dyslipidemia
Q38549782	Clinically Relevant Mechanisms of Lipid Synthesis, Transport, and Storage
Q35111476	Clinically used selective oestrogen receptor modulators increase LDL receptor activity in primary human lymphocytes.
Q30319871	Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs
Q46510270	Cloning and Characterization of Lxr and Srebp1, and Their Potential Roles in Regulation of LC-PUFA Biosynthesis in Rabbitfish Siganus canaliculatus
Q42685997	Cloning, comparative characterization of porcine SCAP gene, and identification of its two splice variants
Q40260041	Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.
Q33267280	Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profiling
Q89810232	Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice
Q36503263	Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue
Q24683425	Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
Q84509552	Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats
Q64108612	Combined effects of ambient particulate matter exposure and a high-fat diet on oxidative stress and steatohepatitis in mice
Q25255682	Combined expression trait correlations and expression quantitative trait locus mapping
Q38619155	Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems.
Q92267409	Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH
Q34600814	Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats
Q33464797	Comparison of electrospray ionization and atmospheric chemical ionization coupled with the liquid chromatography-tandem mass spectrometry for the analysis of cholesteryl esters
Q37087635	Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue
Q28508811	Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver
Q37325136	Complex assembly on the human CYP17 promoter
Q37400096	Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Q33591054	Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai
Q37496600	Conjugated and free sterols from black bean (Phaseolus vulgaris L.) seed coats as cholesterol micelle disruptors and their effect on lipid metabolism and cholesterol transport in rat primary hepatocytes.
Q30855130	Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.
Q34949033	Consequences of cellular cholesterol accumulation: basic concepts and physiological implications
Q34472170	Consequences of exchanging carbohydrates for proteins in the cholesterol metabolism of mice fed a high-fat diet
Q33953637	Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Q36289207	Construction and evaluation of an adenoviral vector for the liver-specific expression of the serine/arginine-rich splicing factor, SRSF3.
Q37034365	Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver
Q37486355	Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms
Q91673069	Control of LDL Uptake in Human Cells by Targeting the LDLR Regulatory Long Non-coding RNA BM450697
Q49211331	Control of Muscle Metabolism by the Mediator Complex
Q34119006	Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase
Q36650322	Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation
Q35857084	Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
Q34191246	Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice
Q44512717	Copper induces the expression of cholesterogenic genes in human macrophages
Q33727315	Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes.
Q92059085	Corticosterone-mediated physiological stress modulates hepatic lipid metabolism, metabolite profiles, and systemic responses in chickens
Q33874248	Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes
Q93161614	CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling
Q88064814	Curcumin and dietary polyphenol research: beyond drug discovery
Q38840947	Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes
Q37482957	Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1
Q41919315	Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells
Q97526776	Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
Q26749224	Current trends in oxysterol research
Q35688145	Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production
Q36911423	Cytochrome P450--physiological key factor against cholesterol accumulation and the atherosclerotic vascular process
Q24320231	DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation
Q97525815	Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
Q34626518	Deciphering the nuclear bile acid receptor FXR paradigm
Q36063700	Deciphering the roles of the constitutive androstane receptor in energy metabolism
Q34510189	Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe
Q92398568	Decoding inflammation, its causes, genomic responses, and emerging countermeasures
Q28588292	Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
Q93000058	Deep transcriptome analysis using RNA-Seq suggests novel insights into molecular aspects of fat-tail metabolism in sheep
Q43215288	Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease
Q35027768	Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice
Q33706071	Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism
Q47875169	Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis
Q37089101	Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
Q34565290	Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance
Q50978081	Deletion of HNF1α in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice.
Q37081953	Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
Q46755385	Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification
Q33695928	Desalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells
Q39877327	Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line
Q46699493	Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes
Q36744605	Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake
Q90282381	Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling
Q37444112	Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice
Q38653024	Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
Q35499561	Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism
Q38105993	Diagnosis and management of familial dyslipoproteinemias
Q35800445	Diet as a risk factor for cholesterol gallstone disease.
Q36125408	Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice
Q90596855	Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
Q43481512	Diet-induced dyslipidemia impairs reverse cholesterol transport in hamsters
Q47956509	Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity-Related Genes
Q92662926	Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice
Q34076091	Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys
Q33999048	Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway
Q50677335	Dietary cholesterol supplementation to a plant-based diet suppresses the complete pathway of cholesterol synthesis and induces bile acid production in Atlantic salmon (Salmo salar L.).
Q34661688	Dietary fat content and fiber type modulate hind gut microbial community and metabolic markers in the pig.
Q35992718	Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model.
Q36221625	Dietary fiber prevents obesity-related liver lipotoxicity by modulating sterol-regulatory element binding protein pathway in C57BL/6J mice fed a high-fat/cholesterol diet
Q28569638	Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats
Q40987059	Dietary restriction, caloric value and the accumulation of hepatic fat.
Q33758991	Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling
Q36335120	Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats
Q39450746	Dietary ɛ-Polylysine Decreased Serum and Liver Lipid Contents by Enhancing Fecal Lipid Excretion Irrespective of Increased Hepatic Fatty Acid Biosynthesis-Related Enzymes Activities in Rats
Q35048444	Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats
Q41888201	Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes
Q89954501	Differential effects of Chinese high-fat dietary habits on lipid metabolism: mechanisms and health implications
Q44619259	Differential effects of polyunsaturated fatty acids on sterol synthesis rates in adult and fetal tissues of the hamster: consequence of altered sterol balance
Q30492215	Differential expression and function of ABCG1 and ABCG4 during development and aging
Q36769335	Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums
Q84763447	Differential expression of lipid metabolism related genes in porcine muscle tissue leading to different intramuscular fat deposition
Q36198324	Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains.
Q30412216	Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading
Q28743462	Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance
Q28085501	Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome
Q37066522	Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.
Q37008856	Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production
Q39848785	Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation
Q37511111	Disruption of cholesterol homeostasis by plant sterols
Q36196777	Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia
Q34536893	Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning
Q36867631	Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice.
Q37472798	Dissecting the role of insulin resistance in the metabolic syndrome
Q28506866	Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo
Q55197599	Distinct correlations between lipogenic gene expression and fatty acid composition of subcutaneous fat among cattle breeds.
Q28513775	Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c
Q28586335	Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model
Q47708428	Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
Q34190312	Diversity, topographic differentiation, and positional memory in human fibroblasts
Q24553299	Do oxysterols control cholesterol homeostasis?
Q36725271	Docosahexaenoic acid (DHA) and hepatic gene transcription
Q38352477	Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells
Q28576771	Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways
Q47923241	Does Sirt2 Regulate Cholesterol Biosynthesis During Oligodendroglial Differentiation In Vitro and In Vivo?
Q37659358	Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey
Q37155389	Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs
Q49959094	Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Q36300675	Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition
Q33260941	Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs
Q26866577	Dual functions of Insig proteins in cholesterol homeostasis
Q28540472	Dual mode action of mangiferin in mouse liver under high fat diet
Q90466739	Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply
Q64113157	Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis
Q45298923	Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.
Q37135525	Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase
Q37076334	Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
Q59340519	Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model
Q33746400	Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling
Q36727852	Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury
Q37033133	E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.
Q34296575	EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
Q33396126	ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.
Q61444249	ENOblock inhibits the pathology of diet-induced obesity
Q37685967	ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes.
Q33620277	ER stress and hepatic lipid metabolism
Q42088790	ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum
Q35313420	Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression
Q50959095	Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer's disease.
Q34221799	Early steps in steroidogenesis: intracellular cholesterol trafficking
Q53270887	Effect and mechanism of waterborne prolonged Zn exposure influencing hepatic lipid metabolism in javelin goby Synechogobius hasta.
Q33494969	Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
Q35783538	Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis
Q41064729	Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats.
Q99246655	Effect of INSIG1 on the milk fat synthesis of buffalo mammary epithelial cells
Q41006475	Effect of anti-hyperlipidemia drugs on the alpha-tocopherol concentration and their potential for murine malaria infection
Q42995318	Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice
Q49923423	Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells.
Q28588503	Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia
Q41498850	Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets
Q99578828	Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice
Q33804734	Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet
Q50108375	Effect of genetic polymorphisms in SREBF-SCAP pathway on therapeutic response to rosuvastatin in Saudi metabolic syndrome patients.
Q36951041	Effect of high-intensity exercise and high-fat diet on lipid metabolism in the liver of rats
Q35122536	Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1-infected patients
Q30986308	Effect of the feeding system on the fatty acid composition, expression of the Delta9-desaturase, Peroxisome Proliferator-Activated Receptor Alpha, Gamma, and Sterol Regulatory Element Binding Protein 1 genes in the semitendinous muscle of light [...]
Q55132113	Effects of Dietary Intake of Japanese Mushrooms on Visceral Fat Accumulation and Gut Microbiota in Mice.
Q91656920	Effects of Gelidium elegans on Weight and Fat Mass Reduction and Obesity Biomarkers in Overweight or Obese Adults: A Randomized Double-Blinded Study
Q35053466	Effects of HIV protease inhibitor therapy on lipid metabolism
Q34987299	Effects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice.
Q92082401	Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice
Q33959600	Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin
Q34955169	Effects of adiposity on plasma lipid response to reductions in dietary saturated fatty acids and cholesterol
Q34776347	Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism
Q38289690	Effects of atherogenic diet and atorvastatin treatment on gene expression profiles in the C57BL/6J mouse liver
Q39474573	Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor
Q27312061	Effects of dietary pantothenic acid on growth, intestinal function, anti-oxidative status and fatty acids synthesis of juvenile blunt snout bream Megalobrama amblycephala
Q48638860	Effects of dietary sea cucumber saponin on the gene expression rhythm involved in circadian clock and lipid metabolism in mice during nighttime-feeding
Q46097289	Effects of elevated fatty acid and glucose concentrations on pancreatic islet function in vitro
Q64249304	Effects of feeding ethanol on growth performances, carcass characteristics, and lipid metabolism of finishing Korean cattle (Hanwoo) steers
Q30319689	Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens
Q35609581	Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus
Q42367387	Effects of ingredients of Korean brown rice cookies on attenuation of cholesterol level and oxidative stress in high-fat diet-fed mice
Q35349492	Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages
Q44783076	Effects of phenotypic residual feed intake on response to a glucose tolerance test and gene expression in the insulin signaling pathway in longissimus dorsi in beef cattle
Q43515242	Effects of simvaglyzin and atorvaglyzin on the expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase in rat liver.
Q51320999	Effects of soyabean meal- or whey-based diets on lipid metabolism in weaned piglets.
Q35834373	Effects of sterol regulatory element-binding protein (SREBP) in chickens
Q51063528	Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition.
Q46984001	Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats
Q48226610	Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice.
Q93079612	Egg white hydrolysate enhances insulin sensitivity in high-fat diet-induced insulin-resistant rats via Akt activation
Q93251378	Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux
Q37640920	Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia.
Q36727408	Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition
Q39233176	Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer
Q41377073	Emerging roles of SIRT1 in fatty liver diseases
Q37287593	Endocrine and paracrine role of bile acids
Q34545426	Endocrine functions of bile acids
Q38742656	Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer
Q40445739	Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.
Q38863830	Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis
Q37250797	Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells
Q38557011	Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease
Q37834712	Endoplasmic reticulum stress and lipid dysregulation
Q47449487	Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes.
Q39148101	Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells
Q88031578	Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells
Q26996783	Energy metabolism in the liver
Q35022447	Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation
Q37724743	Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats
Q64098523	Enhanced early-life nutrition upregulates cholesterol biosynthetic gene expression and Sertoli cell maturation in testes of pre-pubertal Holstein bulls
Q35646093	Enhanced fatty acid flux triggered by adiponectin overexpression
Q54373460	Epidemiology: Chronic disease, cancer, and exercise - a common link.
Q64234550	Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice
Q33577973	Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation
Q24339552	Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis
Q86847327	Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice
Q52599636	Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease.
Q57687713	European Obesity Summit (EOS) - Joint Congress of EASOand IFSO-EC, Gothenburg, Sweden, June 1 - 4, 2016: Abstracts
Q90503839	Even Cancer Cells Watch Their Cholesterol!
Q28756853	Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species
Q37426801	Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
Q93052749	Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets
Q87756489	Exenatide Prevents Diet-induced Hepatocellular Injury in A CEACAM1-Dependent Mechanism
Q54941250	Exenatide induces carcinoembryonic antigen-related cell adhesion molecule 1 expression to prevent hepatic steatosis.
Q28294805	Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle
Q37561703	Experimental rat models to study the metabolic syndrome
Q37986051	Exploitation of lipid components by viral and host proteins for hepatitis C virus infection
Q35827127	Exploration of the Hypothalamic-Pituitary-Adrenal Axis to Improve Animal Welfare by Means of Genetic Selection: Lessons from the South African Merino
Q24815022	Exploring hepatic hormone actions using a compilation of gene expression profiles
Q40494469	Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands
Q40646962	Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion
Q39271419	Expression of R132H mutational IDH1 in human U87 glioblastoma cells affects the SREBP1a pathway and induces cellular proliferation
Q37696792	Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.
Q90494043	Expression of SREBP2 and cholesterol metabolism related genes in TCGA glioma cohorts
Q33962008	Expression of fatty acid synthase in nonalcoholic fatty liver disease.
Q35120129	Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken
Q34231924	Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation
Q36877761	Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats
Q34138315	Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling
Q51737577	FXR Activation by Obeticholic Acid or Non-Steroidal Agonists Induces a Human-Like Lipoprotein Cholesterol Change in Mice with Humanized Chimeric Liver.
Q45068059	Factors affecting adipose tissue development in chickens: A review
Q58555382	Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease
Q41779360	Familial hypercholesterolaemia
Q57818471	Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice
Q37508029	Farnesoid X receptor-Acting through bile acids to treat metabolic disorders.
Q35921709	Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
Q40690647	Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
Q33856101	Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling
Q97527055	Fatty Acid Composition and Regulatory Gene Expression in Late-Term Embryos of ACRB and COBB Broilers
Q57373134	Fatty Acid Regulation of Gene Transcription
Q35139141	Fatty acid signaling: the new function of intracellular lipases
Q51795557	Fatty acid supplied as triglyceride regulates SRE-mediated gene expression as efficiently as free fatty acids.
Q49960728	Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
Q35343063	Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan.
Q37613511	Fatty acid-regulated transcription factors in the liver
Q47846781	Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway.
Q38678326	Fatty liver and FGF21 physiology
Q91551847	Fatty liver diseases, mechanisms, and potential therapeutic plant medicines
Q92614731	Fatty liver formation in fulminant type 1 diabetes
Q92759389	Feature Article: Transplantation of neuregulin 4-overexpressing adipose-derived mesenchymal stem cells ameliorates insulin resistance by attenuating hepatic steatosis
Q37168356	Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
Q28512190	Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis
Q37173755	Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase
Q43293545	Feeding pregnant rats a low-protein diet alters the hepatic expression of SREBP-1c in their offspring via a glucocorticoid-related mechanism
Q55036636	Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome.
Q35092731	Fermentation of soy milk via Lactobacillus plantarum improves dysregulated lipid metabolism in rats on a high cholesterol diet
Q36184925	Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats.
Q47970720	Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice
Q26766528	Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
Q58107270	Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism
Q42359780	Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions
Q35338937	Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
Q41815877	Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway
Q38023567	Flavonoids and metabolic syndrome
Q57149857	Flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats modulate lipid metabolism and biliary cholesterol secretion in C57BL/6 mice
Q47997031	Flavonoids extracted from Linaria vulgaris protect against hyperlipidemia and hepatic steatosis induced by western-type diet in mice
Q35769202	Flaxseed Oil Containing α -Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
Q85394276	Fluoxetine induces hepatic lipid accumulation via both promotion of the SREBP1c-related lipogenesis and reduction of lipolysis in primary mouse hepatocytes
Q91167055	Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression
Q33777071	Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome
Q35451879	Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis
Q36016844	FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c
Q26997647	From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport
Q37126009	From fatty streak to fatty liver: 33 years of joint publications in the JCI
Q35078197	From gallstones to genes: two hundred years of sterol research. A tribute to George J. Schroepfer Jr.
Q37596560	From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis
Q26801099	Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity
Q47340121	Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways
Q34117313	Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
Q93127569	Function and Transcriptional Regulation of Bovine TORC2 Gene in Adipocytes: Roles of C/EBP, XBP1, INSM1 and ZNF263
Q34359084	Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells
Q90640539	Functional Comparison of High and Low Molecular Weight Chitosan on Lipid Metabolism and Signals in High-Fat Diet-Fed Rats
Q33720216	Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea).
Q44770240	Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution
Q26744062	Fundamentals of cancer metabolism
Q37625838	GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
Q28834044	GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway
Q36173755	GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice
Q92508950	GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells
Q42237860	GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion
Q38303031	GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells
Q33616651	Gelidium elegans Regulates the AMPK-PRDM16-UCP-1 Pathway and Has a Synergistic Effect with Orlistat on Obesity-Associated Features in Mice Fed a High-Fat Diet
Q91831481	Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet
Q33309487	Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells
Q33356782	Gene networks driving bovine milk fat synthesis during the lactation cycle
Q28190497	Gene switching by metabolic enzymes--how did you get on the invitation list?
Q47140917	Generation of patient specific human neural stem cells from Niemann-Pick disease type C patient-derived fibroblasts
Q50422447	Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance
Q43291536	Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis
Q35617057	Genetic alterations affecting cholesterol metabolism and human fertility
Q40473012	Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.
Q33867059	Genetic control of de novo lipogenesis: role in diet-induced obesity
Q37411799	Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins
Q47690946	Genetic variation in the MITF promoter affects skin colour and transcriptional activity in black-boned chickens
Q43299076	Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study
Q34281148	Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels
Q36924747	Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2
Q24299109	Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
Q37310596	Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif.
Q42324809	Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes
Q38502786	Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy
Q33354965	Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
Q42793008	Gentiana manshurica Kitagawa Reverses Acute Alcohol-Induced Liver Steatosis through Blocking Sterol Regulatory Element-Binding Protein-1 Maturation
Q39659977	Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells
Q36057216	Ginsenoside Rg3 reduces lipid accumulation with AMP-Activated Protein Kinase (AMPK) activation in HepG2 cells
Q38300652	Glia-induced neuronal differentiation by transcriptional regulation
Q34458474	Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration
Q34008340	Global metabolic effects of glycerol kinase overexpression in rat hepatoma cells
Q40990999	Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis
Q34244209	Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
Q36275975	Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
Q30318687	Glutathione deficiency down-regulates hepatic lipogenesis in rats
Q37189493	Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation
Q27687782	Glycerolipid and cholesterol ester analyses in biological samples by mass spectrometry
Q37410185	Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
Q36478902	Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation
Q39004649	Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
Q38834993	Golgi Associated HIF1a Serves as a Reserve in Melanoma Cells
Q35314103	Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR).
Q41255108	Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy.
Q42829572	Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes
Q41100060	HBx truncation mutants differentially modulate SREBP-1a and -1c transcription and HBV replication
Q42149934	HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway
Q92715714	HCMV-encoded IE2 promotes NAFLD progression by up-regulation of SREBP1c expression in UL122 genetically modified mice
Q38293471	HDLs, diabetes, and metabolic syndrome
Q44922052	HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes.
Q34617496	HIV protease inhibitors in gut barrier dysfunction and liver injury
Q35184027	HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication
Q39100782	HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism
Q24624413	Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin
Q47153617	Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis
Q89947617	Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
Q38733740	Heat-Killed Lactobacillus salivarius and Lactobacillus johnsonii Reduce Liver Injury Induced by Alcohol In Vitro and In Vivo.
Q36765180	Hedgehog signaling and steroidogenesis
Q38001336	Hepatic ABC transporters and triglyceride metabolism.
Q35737630	Hepatic ABCA1 and VLDL triglyceride production
Q40631328	Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue
Q52594706	Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice.
Q39141580	Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation
Q34094336	Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia
Q34442922	Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation
Q84008571	Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome?
Q37163041	Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6
Q64096707	Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Q90227054	Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice
Q33840844	Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury
Q37130242	Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice
Q28581281	Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids
Q40404141	Hepatic fatty acid biosynthesis is more responsive to protein than carbohydrate in rainbow trout during acute stimulations
Q37665444	Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins
Q34609585	Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
Q42947256	Hepatic iron loading in mice increases cholesterol biosynthesis.
Q41208609	Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome
Q58596261	Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model
Q93064624	Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2
Q35104088	Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2
Q38009669	Hepatic steatosis in type 1 diabetes
Q91062570	Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases
Q42009283	Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
Q45952314	Hepatic-specific activation of peroxisome proliferator-activated receptor γ coactivator-1β protects against steatohepatitis.
Q27481013	Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
Q27488294	Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT Pathway
Q27490446	Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice
Q29620653	Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids
Q24652319	Hepatitis C virus hijacks host lipid metabolism
Q36913366	Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly
Q37527686	Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies
Q52583858	Hepatocellular Carcinoma-associated Protein TD26 Interacts and Enhances SREBP1 Activity to Promote Tumor Cell Proliferation and Growth.
Q90142977	Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice
Q24652495	Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine
Q33613991	Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.
Q47428749	Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice
Q39377977	Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
Q34675761	Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
Q26752622	Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities
Q41899072	Hepatoprotective Potential of Prosopis farcta Beans Extracts against Acetaminophen-induced Hepatotoxicity in Wister Rats
Q53134487	Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats.
Q35691565	Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice
Q92068346	Heterozygous Disruption of Beclin 1 Alleviates Zinc Oxide Nanoparticles-Induced Disturbance of Cholesterol Biosynthesis in Mouse Liver
Q37050327	Hexavalent chromium-induced alteration of proteomic landscape in human skin fibroblast cells
Q90384304	High Energy Intake Induced Overexpression of Transcription Factors and Its Regulatory Genes Involved in Acceleration of Hepatic Lipogenesis: A Rat Model for Type 2 Diabetes
Q44084511	High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.).
Q52585959	High-content screen for modifiers of Niemann-Pick Type C disease in patient cells.
Q51763141	High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations.
Q34799099	High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex
Q43215242	High-starch diets induce precocious adipogenic gene network up-regulation in longissimus lumborum of early-weaned Angus cattle
Q35231302	Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytes
Q28484950	Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux
Q30440164	Hormonal regulation of testicular steroid and cholesterol homeostasis
Q64067571	How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication
Q24606762	Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)
Q36322128	Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents
Q35588477	Human fatty liver disease: old questions and new insights
Q36314748	Human low-density lipoprotein receptor gene and its regulation
Q27004438	Hydrogen peroxide sensing, signaling and regulation of transcription factors
Q64078914	Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells
Q36629792	Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice
Q97652933	Hyperglycemia-stimulating diet induces liver steatosis in sheep
Q45219986	Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors
Q35905331	Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
Q36953661	Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models.
Q33920062	Hyperphosphorylation regulates the activity of SREBP1 during mitosis
Q46526262	Hypolipidaemic effect of maize starch with different amylose content in ovariectomized rats depends on intake amount of resistant starch
Q30319539	Hypolipidaemic effects of potato protein and fish protein in pigs
Q38347242	Hypolipidemic effect of dietary pea proteins: Impact on genes regulating hepatic lipid metabolism.
Q39277489	Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice
Q38765909	Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis
Q64941088	Hypothalamic gene transfer of BDNF promotes healthy aging in mice.
Q43260810	Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN.
Q90351515	Hypoxia: A breath of fresh air for the meibomian gland
Q37376114	IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis
Q48171842	IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis
Q37949664	IL-6/IL-6 receptor system and its role in physiological and pathological conditions
Q33728329	INSIG1 influences obesity-related hypertriglyceridemia in humans.
Q36790115	INSIG2 variants, dietary patterns and metabolic risk in Samoa
Q30432659	Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans
Q34212011	Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia
Q36479650	Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
Q64375311	Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor
Q37726237	Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c
Q37352148	Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
Q34519267	Identification of genes whose expression is altered by obesity throughout the arterial tree.
Q31035638	Identification of high-copper-responsive target pathways in Atp7b knockout mouse liver by GSEA on microarray data sets
Q35036420	Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids
Q34979050	Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis
Q33432792	Identification of novel genes and pathways regulating SREBP transcriptional activity
Q36288686	Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
Q36836017	Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.
Q34544753	Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts
Q37682496	Immunologic, metabolic and genetic factors in hepatitis C virus infection
Q91945216	Immunometabolism and natural killer cell responses
Q26749628	Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes
Q36017816	Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation
Q37183381	Impact of genetic polymorphisms on the efficacy of HMG-CoA reductase inhibitors.
Q46839764	Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta
Q34735669	Impact of oxLDL on Cholesterol-Rich Membrane Rafts
Q91905927	Impact of psychiatric comorbidity on the severity, short-term functional outcome, and psychiatric complications after acute stroke
Q54979827	Impact of silencing hepatic SREBP-1 on insulin signaling.
Q37610670	Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease
Q34378904	Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4
Q92890070	Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
Q43236613	Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype.
Q64928861	Implementation of environmental enrichment after middle age promotes healthy aging.
Q89697924	In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis
Q36217591	In ovo leptin administration affects hepatic lipid metabolism and microRNA expression in newly hatched broiler chickens
Q39089992	In vitro exposure to copper influences lipid metabolism in hepatocytes from grass carp (Ctenopharyngodon idellus).
Q44297509	In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model
Q37264829	Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues
Q52690273	Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes.
Q34089899	Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
Q46253871	Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion
Q42396896	Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages
Q40068676	Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin
Q54977313	Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin.
Q34672477	Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.
Q38289418	Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats
Q35186665	Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.
Q47271342	Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut
Q28510700	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis
Q97519188	Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis: BECN1 and P4 elevation in endometriosis
Q33842597	Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes
Q92052851	Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease
Q37299994	Influence of genotype on the modulation of gene and protein expression by n-3 LC-PUFA in rats
Q37194960	Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells
Q54223483	Influence of virgin coconut oil-enriched diet on the transcriptional regulation of fatty acid synthesis and oxidation in rats - a comparative study.
Q64069791	Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
Q90169703	Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
Q33612522	Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway
Q40630837	Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation
Q34205103	Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Q42684428	Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis
Q92885348	Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy
Q42631278	Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.
Q48127350	Inhibition of exendin-4-induced steatosis by protein kinase A in cultured HepG2 human hepatoma cells
Q28729212	Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice
Q64927546	Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase.
Q36189861	Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
Q35606800	Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.
Q39568148	Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia
Q34103753	Inhibition of obesity-induced hepatic ER stress by early insulin therapy in obese diabetic rats
Q39531917	Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells.
Q37511728	Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine
Q24681212	Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes
Q24307390	Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
Q40753400	Insig: a significant integrator of nutrient and hormonal signals
Q36466124	Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.
Q28581484	Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
Q37126710	Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex
Q38663211	Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor
Q35049218	Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Q34467208	Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3.
Q35561045	Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice
Q44839519	Insulin resistance, serum adipokines and risk of fibrosis progression in patients transplanted for hepatitis C.
Q42206112	Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study
Q37785391	Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective
Q36342908	Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
Q34212126	Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice
Q35037837	Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.
Q38358901	Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts
Q33952316	Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions
Q61136557	Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
Q55040220	Intake of 3 Eggs per Day When Compared to a Choline Bitartrate Supplement, Downregulates Cholesterol Synthesis without Changing the LDL/HDL Ratio.
Q90359982	Integrated Analys of High-Fat Challenge-Induced Changes in Blood Cell Whole-Genome Gene Expression
Q41885229	Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.
Q37983638	Interaction networks of hepatitis C virus NS4B: implications for antiviral therapy
Q37788976	Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis.
Q52724160	Interlink between cholesterol & cell cycle in prostate carcinoma.
Q47553435	Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice
Q83523156	Interrelated effects of dihomo-γ-linolenic and arachidonic acids, and sesamin on hepatic fatty acid synthesis and oxidation in rats
Q34985745	Intersection of the unfolded protein response and hepatic lipid metabolism
Q38234847	Intestinal nuclear receptors in HDL cholesterol metabolism
Q42008733	Intracellular delivery strategies for microRNAs and potential therapies for human cardiovascular diseases
Q37463283	Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells
Q24658154	Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
Q44574966	Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity
Q35171937	Investigation of de novo cholesterol synthetic capacity in the gonads of goldfish (Carassius auratus) exposed to the phytosterol beta-sitosterol
Q33642067	Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells
Q42216601	Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury
Q30559384	Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome.
Q100406084	Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis
Q91666114	Iron overload reduces synthesis and elimination of bile acids in rat liver
Q28075486	Is REDD1 a Metabolic Éminence Grise?
Q33911138	Is alcohol beneficial or harmful for cardioprotection?
Q38357914	Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice
Q60947803	Isoquercetin Improves Hepatic Lipid Accumulation by Activating AMPK Pathway and Suppressing TGF-β Signaling on an HFD-Induced Nonalcoholic Fatty Liver Disease Rat Model
Q91173877	Isorhamnetin Alleviates Steatosis and Fibrosis in Mice with Nonalcoholic Steatohepatitis
Q37231144	Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding
Q28580518	Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells
Q37098581	Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway
Q37590276	Key intestinal genes involved in lipoprotein metabolism are downregulated in dyslipidemic men with insulin resistance.
Q58765163	Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer
Q102053746	Key role for lipids in cognitive symptoms of schizophrenia
Q35749416	Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
Q41240626	Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions.
Q36319877	Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis
Q90092009	Knockout of Stat5 in T cells ameliorates high cholesterol and high fat diet-induced hypercholesterolemia by influencing cholesterol metabolism in the liver
Q37002627	Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver
Q28506083	Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
Q90213130	LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Q35758221	LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
Q54945090	LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells.
Q98241464	Lack of Augmenter of Liver Regeneration Disrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPK Pathway
Q37215867	Lack of association between SREBF-1c gene polymorphisms and risk of non-alcoholic fatty liver disease in a Chinese Han population
Q30425020	Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci
Q35834429	Lean gene and the clock machine
Q47237304	Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet
Q37474320	Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
Q33602487	Leptin revisited: its mechanism of action and potential for treating diabetes
Q42009740	Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training
Q50987394	Lifelong exposure to dietary isoflavones reduces risk of obesity in ovariectomized Wistar rats.
Q43088910	Lignophenols decrease oleate-induced apolipoprotein-B secretion in HepG2 cells
Q38810328	Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
Q42729920	Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.
Q47754576	Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells.
Q39253589	Lipid droplets and liver disease: from basic biology to clinical implications.
Q58077805	Lipid mediators of liver injury in nonalcoholic fatty liver disease
Q30684049	Lipid metabolism emerges as a promising target for malignant glioma therapy
Q44835133	Lipid metabolism fattens up hedgehog signaling
Q88761261	Lipid metabolism reprogramming and its potential targets in cancer
Q37731005	Lipid metabolism-related gene expression pattern of Atlantic bluefin tuna (Thunnus thynnus L.) larvae fed on live prey
Q36323141	Lipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer
Q34131027	Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides
Q46890519	Lipid synthesis in lactation: diet and the fatty acid switch
Q40366577	Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor
Q108685161	Lipid-based therapies against SARS-CoV-2 infection
Q34506022	Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment
Q35961350	Lipid-regulating effect of traditional chinese medicine: mechanisms of actions
Q37339704	Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small Cell Lung Cancer
Q40033380	Lipidomics: a new window to biomedical frontiers.
Q37524335	Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus
Q35515576	Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation.
Q37039775	Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation
Q41661616	Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity.
Q41853980	Lipopolysaccharides accelerate hepatic steatosis in the development of nonalcoholic fatty liver disease in Zucker rats
Q34990605	Lipoprotein heterogeneity: diagnostic and therapeutic implications
Q35754362	Lipoprotein kinetics in the metabolic syndrome: pathophysiological and therapeutic lessons from stable isotope studies
Q37705810	Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease
Q27332377	Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition
Q37544267	Lipoproteins, cholesterol homeostasis and cardiac health
Q81127015	Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
Q35876818	Liraglutide prevents hypoadiponectinemia-induced insulin resistance and alterations of gene expression involved in glucose and lipid metabolism
Q36898227	Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5'-Monophosphate (AMP)-activated Protein Kinase α1.
Q46861751	Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule
Q80695266	Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals
Q46442905	Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.
Q34205850	Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status
Q36411128	Liver X receptors as integrators of metabolic and inflammatory signaling
Q38462005	Liver X receptors as regulators of metabolism.
Q27010631	Liver steatosis in hepatitis C patients
Q42954995	Liver x receptor: a novel therapeutic target
Q37105304	Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
Q34835012	Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
Q34171384	Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass
Q24554492	Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis
Q97643839	Lnc-ing microRNA activity to atheroprotection
Q28510849	Local regulation of fat metabolism in peripheral nerves
Q64961324	Long non‑coding RNA HR1 participates in the expression of SREBP‑1c through phosphorylation of the PDK1/AKT/FoxO1 pathway.
Q64099274	Long-Term Feeding of Soy Protein Attenuates Choline Deficient-Induced Adverse Effects in Wild Type Mice and Prohibitin 1 Deficient Mice Response More Sensitively
Q37014966	Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes
Q35208528	Long-term hyperphagia and caloric restriction caused by low- or high-density husbandry have differential effects on zebrafish postembryonic development, somatic growth, fat accumulation and reproduction
Q50930149	Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet.
Q34342477	Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice
Q33918846	Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis.
Q36847534	Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis
Q90410097	Loss of HNF1α Function Contributes to Hepatocyte Proliferation and Abnormal Cholesterol Metabolism via Downregulating miR-122: A Novel Mechanism of MODY3
Q39128964	Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease
Q30443685	Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity
Q57794656	Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis
Q40646911	Low-temperature effect on the sterol-dependent processing of SREBPs and transcription of related genes in HepG2 cells
Q47132548	Lunasin functionally enhances LDL uptake via inhibiting PCSK9 and enhancing LDLR expression in vitro and in vivo
Q89985629	Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis
Q30319047	Lupin protein acts hypocholesterolemic and increases milk fat content in lactating rats by influencing the expression of genes involved in cholesterol homeostasis and triglyceride synthesis
Q30319037	Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults
Q30319700	Lupin protein influences the expression of hepatic genes involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats
Q38995005	Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice
Q92862044	Lysosomal acid lipase deficiency - early diagnosis is the key
Q39371640	Lysosomal acid lipase deficiency: a form of non-obese fatty liver disease (NOFLD).
Q36057629	MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
Q50934689	MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population.
Q37130478	MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment
Q28609710	Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins
Q28790189	Malformation syndromes due to inborn errors of cholesterol synthesis
Q39136059	Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency
Q30244206	Mangiferin modulation of metabolism and metabolic syndrome
Q37163024	Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling
Q50053108	Maraviroc improves hepatic triglyceride content but not inflammation in a murine nonalcoholic fatty liver disease model induced by a chronic exposure to high-fat diet.
Q59791398	Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring
Q45075424	Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses.
Q90124248	Maternal folic acid supplementation does not counteract the deleterious impact of prenatal exposure to environmental pollutants on lipid homeostasis in male rat descendants
Q36951291	Maternal hypercholesterolemia leads to activation of endogenous cholesterol synthesis in the offspring
Q34129747	Maternal magnesium deficiency in mice leads to maternal metabolic dysfunction and altered lipid metabolism with fetal growth restriction
Q41682399	Maternal resveratrol intake during lactation attenuates hepatic triglyceride and fatty acid synthesis in adult male rat offspring
Q34482862	Maturation and activity of sterol regulatory element binding protein 1 is inhibited by acyl-CoA binding domain containing 3.
Q37530120	MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex
Q27321213	Meal time shift disturbs circadian rhythmicity along with metabolic and behavioral alterations in mice
Q35022533	Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription
Q28567638	Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation
Q92059973	Mechanisms and regulation of cholesterol homeostasis
Q90685522	Mechanisms of Insulin Action and Insulin Resistance
Q37785293	Mechanisms of LDL oxidation
Q33898945	Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis
Q36956040	Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
Q36558384	Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
Q36788344	Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
Q36052468	Mechanisms of regulation of gene expression by fatty acids
Q38770951	Mechanistic insight into nuclear receptor-mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE).
Q37097833	Mediating lipid biosynthesis: implications for cardiovascular disease
Q34116726	Medicine. HDL miR-ed down by SREBP introns
Q30248650	Mediterranean diet and nonalcoholic fatty liver disease: molecular mechanisms of protection.
Q53189763	Melissa officinalis essential oil reduces plasma triglycerides in human apolipoprotein E2 transgenic mice by inhibiting sterol regulatory element-binding protein-1c-dependent fatty acid synthesis.
Q90607848	Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism
Q104136828	Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease
Q33769884	Metabolic and transcriptomic responses of weaned pigs induced by different dietary amylose and amylopectin ratio
Q38662384	Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism
Q97643603	Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism
Q52768568	Metabolic control of YAP and TAZ by the mevalonate pathway.
Q92664771	Metabolic influence on macrophage polarization and pathogenesis
Q48491781	Metabolic programming of sirtuin 1 (SIRT1) expression by moderate energy restriction during gestation in rats may be related to obesity susceptibility in later life
Q26798088	Metabolic regulation of T cell differentiation and function
Q89646829	Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH
Q99207689	Metabolic rivalry: circadian homeostasis and tumorigenesis
Q36461906	Metabolic syndrome: focus on dyslipidemia
Q33594722	Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients
Q35938856	Metabolism of lipids in human white adipocyte
Q35031827	Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues
Q41195887	Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice
Q36262595	Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2).
Q61812025	Mg-supplementation attenuated lipogenic and oxidative/nitrosative gene expression caused by Combination Antiretroviral Therapy (cART) in HIV-1-transgenic rats
Q39704194	MiR-33 contributes to the regulation of cholesterol homeostasis.
Q28504875	Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis
Q37650114	Micro-RNAs and High-Density Lipoprotein Metabolism.
Q37036352	MicroRNA 33 regulates glucose metabolism.
Q27026071	MicroRNA modulation of cholesterol homeostasis
Q38823315	MicroRNA regulation of macrophages in human pathologies
Q37413876	MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3.
Q34750679	MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease
Q38297030	MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
Q37130421	MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting the INSIG1 gene
Q28509140	MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
Q37394060	MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.
Q36910037	MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1)
Q33760162	MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo
Q39195873	MicroRNAs and lipid metabolism.
Q26852606	MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease
Q46822603	MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease
Q24633633	MicroRNAs in lipid metabolism
Q41850658	MicroRNAs in metabolism and metabolic diseases
Q33612997	MicroRNAs in metabolism and metabolic disorders
Q60675346	MicroRNAs regulating lipid metabolism in atherogenesis
Q37294679	Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats
Q37200642	Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
Q50099274	Milk lipid regulation at the maternal-offspring interface
Q36064668	Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice.
Q82824351	Mineralocorticoid hypertension
Q89386524	Minor lipid metabolic perturbations in the liver of Atlantic salmon (Salmo salar L.) caused by suboptimal dietary content of nutrients from fish oil
Q36478196	Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity
Q37339912	Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity
Q38126549	Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?
Q24306617	Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase gene expression by CuZn superoxide dismutase in human fibroblasts and HepG2 cells
Q89944024	Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids
Q36978947	Modulation of hepatitis C virus genome encapsidation by nonstructural protein 4B
Q38309085	Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2.
Q46388639	Modulation of intestinal cholesterol absorption by high glucose levels: impact on cholesterol transporters, regulatory enzymes, and transcription factors.
Q53387154	Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28.
Q35947974	Molecular Cloning, Functional Characterization and Nutritional Regulation of the Putative Elongase Elovl5 in the Orange-Spotted Grouper (Epinephelus coioides)
Q28609443	Molecular and Cell Biology of Phosphatidylserine and Phosphatidylethanolamine Metabolism
Q36089092	Molecular characterization of HLH-17, a C. elegans bHLH protein required for normal larval development
Q39925312	Molecular consequences of altered neuronal cholesterol biosynthesis.
Q97643554	Molecular logic of mTORC1 signalling as a metabolic rheostat
Q37437295	Molecular mechanisms involved in NAFLD progression
Q38569945	Molecular mechanisms of fatty liver in obesity
Q29616709	Molecular mediators of hepatic steatosis and liver injury
Q37972887	Molecular pathology of familial hypercholesterolemia, related dyslipidemias and therapies beyond the statins
Q33890230	Molecular pathways in non-alcoholic fatty liver disease.
Q57807657	Molecular pathways of nonalcoholic fatty liver disease development and progression
Q40414527	Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary
Q35723508	Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis
Q39259280	Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells
Q24803714	Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development
Q35043691	Mouse models as tools for dissecting disorders of lipoprotein metabolism
Q43804565	Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
Q64957324	Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.
Q34501727	Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats
Q26767396	Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways
Q30354662	Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.
Q24302433	Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Q34972521	Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations
Q37156302	N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
Q94517849	NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis
Q35159321	NAFLD, Estrogens, and Physical Exercise: The Animal Model
Q36099612	NOX4 pathway as a source of selective insulin resistance and responsiveness
Q33908866	Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells
Q47569103	Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer.
Q36337964	Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake
Q48909259	Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia
Q89654798	Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking
Q94547493	New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
Q93052075	New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages
Q37788073	New insights into S2P signaling cascades: regulation, variation, and conservation.
Q35521069	New insights into the mechanism of low high-density lipoprotein cholesterol in obesity
Q37374183	New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation.
Q58145237	New mechanisms contributing to hepatic steatosis: glucose, insulin, and lipid signaling
Q39974401	New mutations in C1GALT1C1 in individuals with Tn positive phenotype
Q24628724	Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Q37662878	Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport
Q34187966	Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.
Q47904028	Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase
Q54420633	Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation.
Q42151368	Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance
Q37970350	Non-alcoholic Fatty liver disease: the bile Acid-activated farnesoid x receptor as an emerging treatment target
Q38197690	Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity.
Q61806959	Non-antibody Approaches to Proprotein Convertase Subtilisin Kexin 9 Inhibition: siRNA, Antisense Oligonucleotides, Adnectins, Vaccination, and New Attempts at Small-Molecule Inhibitors Based on New Discoveries
Q89179213	Non-coding RNAs in lipid metabolism
Q33580031	Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming".
Q34412650	Nonalcoholic Fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective
Q37149405	Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment
Q38859044	Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?
Q37229854	Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
Q41640719	Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.
Q36527942	Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways
Q42909043	Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice
Q94672841	Nostoc sphaeroids Kütz ameliorates hyperlipidemia and maintains the intestinal barrier and gut microbiota composition of high-fat diet mice
Q92534729	Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice
Q90580543	Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA
Q90640730	Novel Neohesperidin Dihydrochalcone Analogue Inhibits Adipogenic Differentiation of Human Adipose-Derived Stem Cells through the Nrf2 Pathway
Q28384230	Novel Role of Soluble Epoxide Hydrolase in Regulating Cholesterol in Mammalian Cells
Q46030429	Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent.
Q38355827	Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection.
Q36231628	Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics
Q85641644	Novel modulators of hepatosteatosis, inflammation and fibrogenesis
Q40586604	Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression
Q41001877	Novel role for the CRTC2 in lipid homeostasis
Q93026449	Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis
Q36865812	Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis
Q28076525	Novel treatment options for lysosomal acid lipase deficiency: critical appraisal of sebelipase alfa
Q34810523	Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice
Q35609154	Nuclear receptors in nonalcoholic Fatty liver disease
Q36732028	Nuclear receptors reverse McGarry's vicious cycle to insulin resistance
Q24306217	Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway
Q52324285	Nutrients and Oxidative Stress: Friend or Foe?
Q33582787	Nutrigenomics therapy of hepatisis C virus induced-hepatosteatosis
Q35012948	Nutrigenomics: exploiting systems biology in the nutrition and health arena
Q26770270	O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes
Q33941203	OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62
Q37008626	Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy.
Q37732961	Obesity, cholesterol, and clear-cell renal cell carcinoma (RCC).
Q42356833	Obesity: Rubensian beauty turned into major health problem
Q24679235	Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals
Q35664542	Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model
Q36387184	Omega-3 fatty acid supplementation and cardiovascular disease
Q26825517	Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease
Q38869139	Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.
Q51295693	Osthole improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle in fatty liver rats.
Q90616240	Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum
Q34643522	Other ways to skin a cat: activating SREBP without Scap
Q36658364	Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis
Q41880154	Overactivation of intestinal SREBP2 in mice increases serum cholesterol
Q24631468	Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
Q41541889	Overexpression of Insig-2 inhibits atypical antipsychotic-induced adipogenic differentiation and lipid biosynthesis in adipose-derived stem cells
Q33836878	Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity
Q38572199	Overindulgence and metabolic syndrome: is FoxO1 a missing link?
Q35152219	Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a
Q37164536	Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats
Q36760237	Oxysterol-binding protein family I is the target of minor enviroxime-like compounds.
Q37638753	Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system
Q33917134	Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells
Q41991413	PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus
Q42751911	PAS kinase drives lipogenesis through SREBP-1 maturation.
Q34433146	PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells
Q47134612	PCSK9 signaling pathways and their potential importance in clinical practice
Q35691132	PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis
Q39474407	PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.
Q40923110	PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs
Q28587145	PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling
Q39013884	PKA/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells
Q28582308	PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
Q34671888	PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection
Q91803007	PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux
Q80594539	PPARalpha in the pathogenesis of fatty liver disease
Q33805104	PPARalpha: energy combustion, hypolipidemia, inflammation and cancer
Q34330290	PPARdelta is a very low-density lipoprotein sensor in macrophages
Q89640752	PRMT5 in gene regulation and hematologic malignancies
Q64075627	Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt
Q47676910	Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression
Q90656244	Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis
Q46799280	Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications.
Q36967762	Palmiwon attenuates hepatic lipid accumulation and hyperlipidemia in a menopausal rat model
Q34449857	Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
Q37537264	Pathogenesis of alcoholic liver disease: the role of nuclear receptors
Q90055401	Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome
Q38648556	Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis
Q38584848	Pathophysiological mechanisms of increased cardiometabolic risk in people with schizophrenia and other severe mental illnesses
Q58774678	Pathophysiology of Diabetic Dyslipidemia
Q27022707	Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis
Q34757496	Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments
Q24320126	Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis
Q90720156	Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent
Q60953856	Per-Arnt-Sim Kinase (PASK) Deficiency Increases Cellular Respiration on a Standard Diet and Decreases Liver Triglyceride Accumulation on a Western High-Fat High-Sugar Diet
Q46484710	Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome
Q43942380	Peripheral blood mononuclear cells: a potential source of homeostatic imbalance markers associated with obesity development
Q43167089	Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.
Q24623871	Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
Q42792348	Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease
Q42936021	Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation
Q49789719	Pharmacogenomics of chemically distinct classes of Keap1-Nrf2 activators identify common and unique gene, protein, and pathway responses in vivo
Q37725043	Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics
Q35907138	Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.
Q36987335	Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules
Q57281714	Phosphatidylcholine and phosphatidylethanolamine plasmalogens in lipid loaded human macrophages
Q37284901	Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression
Q37206403	Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin
Q43143155	Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity
Q38944183	Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2.
Q49706850	Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Q42548169	Physiology. Unfolding lipid metabolism
Q34581638	Phytosterols and phytosterolemia: gene-diet interactions
Q89267034	Plasma PCSK9 correlates with apoB-48-containing triglyceride-rich lipoprotein production in men with insulin resistance
Q36662650	Plasma PCSK9 preferentially reduces liver LDL receptors in mice
Q28258554	Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver
Q36554065	Plasma proprotein convertase subtilisin/kexin type 9 levels and the risk of first cardiovascular events
Q39531870	Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis
Q38808338	Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism.
Q38825843	Pleiotropic effects of statins: new therapeutic targets in drug design
Q36850216	Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi
Q46308032	Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples
Q37158095	Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
Q30502199	Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
Q53222845	Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol.
Q47387115	Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
Q38666646	Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c
Q46252515	Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins
Q38119865	Potential mechanisms of atypical antipsychotic-induced hypertriglyceridemia
Q54426300	Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver.
Q41510767	Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression.
Q89916588	Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease
Q35962050	Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity
Q53023338	Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.
Q41431281	Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats
Q35839265	Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat
Q37389108	Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat.
Q41839667	Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer
Q34182797	Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity
Q35717888	Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Q35606085	Primate-specific evolution of an LDLR enhancer
Q37148306	Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis
Q37591701	Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells
Q26765495	Progress and prospects of long noncoding RNAs in lipid homeostasis
Q37064933	Prolactin regulation of mammary gland development.
Q42007845	Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation.
Q33922486	Prosteatotic genes are associated with unsaturated fat suppression of saturated fat-induced hepatic steatosis in C57BL/6 mice
Q90167210	Protection from Endotoxin Shock by Selective Targeting of Proinflammatory Signaling to the Nucleus Mediated by Importin Alpha 5
Q46842563	Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers
Q37397907	Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats.
Q34098522	Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
Q89855474	Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity
Q35838266	Protein mediators of sterol transport across intestinal brush border membrane
Q90019833	Proteolytic Control of Lipid Metabolism
Q46290614	Proteostatic Tactics in the Strategy of Sterol Regulation
Q43154975	Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).
Q54323184	Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice.
Q33543669	Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency
Q38464758	Quercetin up-regulates LDL receptor expression in HepG2 cells
Q39664968	Quercetin up-regulates paraoxonase 1 gene expression via sterol regulatory element binding protein 2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in para
Q64898416	RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
Q42116517	REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1.
Q34246542	RETRACTED ARTICLE: A novel polymorphism of the GP78 gene is associated with coronary artery disease in Han population in China
Q24305480	RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene
Q91752935	RNA-Sequencing Analysis of Paternal Low-Protein Diet-Induced Gene Expression Change in Mouse Offspring Adipocytes
Q39499551	RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo
Q38639202	RNF20 Suppresses Tumorigenesis by Inhibiting SREBP1c-PTTG1 Axis in Kidney Cancer.
Q37802722	RUMINANT NUTRITION SYMPOSIUM: Molecular adaptation of ruminal epithelia to highly fermentable diets1
Q33630411	RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
Q33578758	Rab1 in cell signaling, cancer and other diseases
Q56981583	Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
Q88916888	Rapid communication: lipid metabolic gene expression and triacylglycerol accumulation in goat mammary epithelial cells are decreased by inhibition of SREBP-1
Q43237473	Rapid method for cholesterol analysis in bovine milk and options for applications
Q35089365	Ras pathway signaling on endomembranes
Q46112159	Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury
Q34821020	Recent Advances in Understanding of NASH: MicroRNAs as Both Biochemical Markers and Players
Q91635371	Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways
Q83736486	Recent advances in the regulation of milk fat synthesis
Q34303001	Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease
Q30252210	Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions
Q28184828	Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs
Q36409240	Red clover extract exerts antidiabetic and hypolipidemic effects in db/db mice
Q24301581	Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1
Q37392679	Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1.
Q47098397	Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro
Q37454290	Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes
Q53450573	Regulation and mechanism of leptin on lipid metabolism in ovarian follicle cells from yellow catfish Pelteobagrus fulvidraco.
Q41869580	Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
Q38293434	Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational
Q39985039	Regulation of HMG-CoA reductase expression by hypoxia
Q58282329	Regulation of INSIG2 by microRNA-96
Q38854079	Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk
Q37075782	Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice
Q37947137	Regulation of cholesterol homeostasis
Q39954571	Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha.
Q35559626	Regulation of fatty acid and cholesterol synthesis: co-operation or competition?
Q89790066	Regulation of gene expression during the fasting-feeding cycle of the liver displays mouse strain specificity
Q37996638	Regulation of gene transcription by fatty acids.
Q37826168	Regulation of genes involved in lipid metabolism by dietary oxidized fat
Q26766488	Regulation of glucose metabolism from a liver-centric perspective
Q33816670	Regulation of hepatic gene expression by saturated fatty acids
Q28507784	Regulation of hepatic lipogenesis by the transcription factor XBP1
Q37719350	Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
Q37847726	Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus
Q27009151	Regulation of lipid stores and metabolism by lipophagy
Q34396919	Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1).
Q34342717	Regulation of mTORC1 and its impact on gene expression at a glance
Q39842237	Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
Q33738188	Regulation of the cholesterol biosynthetic pathway and its integration with fatty acid biosynthesis in the oleaginous microalga Nannochloropsis oceanica
Q36302755	Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1.
Q57289164	Regulatory Efficacy of the Polyunsaturated Fatty Acids from Microalgae on Lipid Metabolism and Gut Microbiota in High-Fat Diet Rats
Q42909202	Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARalpha).
Q39427104	Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.).
Q38616121	Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
Q28393663	Reprogramming of lysosomal gene expression by interleukin-4 and Stat6
Q64916831	Resolving the Paradox of Hepatic Insulin Resistance.
Q40567001	Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha
Q53162831	Restriction of dietary protein does not promote hepatic lipogenesis in lean or fatty pigs.
Q35783084	Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)
Q36291200	Resveratrol as a calorie restriction mimetic: therapeutic implications
Q46317478	Resveratrol improves high-fat diet induced fatty liver and insulin resistance by concomitantly inhibiting proteolytic cleavage of sterol regulatory element-binding proteins, free fatty acid oxidation, and intestinal triglyceride absorption
Q57168983	Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
Q93193771	Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal
Q39214040	Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-γ coactivator 1β-dependent pathway
Q46069993	Retracted: Advances in the physiological and pathological implications of cholesterol.
Q38608332	Retrospective on Cholesterol Homeostasis: The Central Role of Scap
Q48526360	Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Q37736580	Review article: omega-3 fatty acids - a promising novel therapy for non-alcoholic fatty liver disease
Q38239205	Revising the high-density lipoprotein targeting strategies - insights from human and preclinical studies
Q35856201	Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key Regulators
Q49647269	Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.
Q34643735	Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation
Q26749020	Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
Q41060685	Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells.
Q91716127	Role of MicroRNAs in Pathophysiology of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
Q34377243	Role of Mitochondria in Alcoholic Liver Disease
Q39153946	Role of Phospholipid Flux during Milk Secretion in the Mammary Gland.
Q92536780	Role of Podocyte Injury in Glomerulosclerosis
Q57066893	Role of SREBPs in Liver Diseases: A Mini-review
Q44723555	Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
Q46045008	Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
Q26738976	Role of bile acids in the regulation of the metabolic pathways
Q36327808	Role of cholesterol and lipid organization in disease
Q90481242	Role of de novo cholesterol synthesis enzymes in cancer
Q58796821	Role of hepatoma-derived growth factor in promoting de novo lipogenesis and tumorigenesis in hepatocellular carcinoma
Q35831223	Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease.
Q33963845	Role of stearoyl-coenzyme A desaturase in lipid metabolism
Q38074996	Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor
Q36020648	Role of the liver in the control of carbohydrate and lipid homeostasis
Q38776796	Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma
Q58702898	Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation
Q36962066	Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance.
Q37826774	Roles of sphingolipids in Drosophila development and disease
Q37980154	Roles of vitamin A status and retinoids in glucose and fatty acid metabolism
Q114371367	Rotavirus exploits SREBP pathway for hyper lipid biogenesis during replication
Q89895213	Running Head: Heat Affects Cholesterol and Bile Acid Alterations in Cholesterol and Bile Acids Metabolism in Large White Pigs during Short-Term Heat Exposure
Q36822549	S-nitrosylation of ARH is required for LDL uptake by the LDL receptor
Q38798359	SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.
Q43593551	SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome
Q64966841	SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy.
Q42817419	SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes
Q37619655	SIRT1 and other sirtuins in metabolism
Q43173436	SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
Q30494316	SLEEP DISORDERED BREATHING AND METABOLIC EFFECTS: EVIDENCE FROM ANIMAL MODELS
Q93147449	SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population
Q83827454	SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?
Q84453638	SREBP isoform and SREBP target gene expression during rat primary hepatocyte culture
Q46455282	SREBP-1 as a transcriptional integrator of circadian and nutritional cues in the liver
Q36728656	SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
Q36709238	SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
Q36930243	SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
Q36617459	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
Q47094029	SREBP-2-driven transcriptional activation of human SND1 oncogene
Q37355532	SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy
Q60912768	SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
Q91923092	SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1
Q47692117	SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
Q41501239	SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
Q64060396	SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
Q38919899	SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism
Q91968324	SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait
Q50294118	SREBP1A,1C binds the SCD gene
Q36650405	SREBP2 Activation Induces Hepatic Long-chain Acyl-CoA Synthetase 1 (ACSL1) Expression in Vivo and in Vitro through a Sterol Regulatory Element (SRE) Motif of the ACSL1 C-promoter.
Q64998467	SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond.
Q47868873	SREBPs suppress IRS-2-mediated insulin signalling in the liver
Q37966406	SREBPs: metabolic integrators in physiology and metabolism
Q30274625	STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites
Q40032390	STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells
Q35573397	Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells
Q41670587	Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high-fat diet
Q28592678	Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation
Q38190465	Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes.
Q33856033	Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk.
Q52715410	Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network.
Q35886299	Scap is required for sterol synthesis and crypt growth in intestinal mucosa
Q42074184	Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice
Q28509016	Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
Q57057017	Science, serendipity, and the single degree
Q34274838	Scientific side trips: six excursions from the beaten path
Q42139418	Sea cucumber cerebrosides and long-chain bases from Acaudina molpadioides protect against high fat diet-induced metabolic disorders in mice
Q41128622	Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1.
Q58868066	Selective Compensatory Induction of Hepatic HMG-CoA Reductase in Response to Inhibition of Cholesterol Absorption
Q38409173	Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer
Q36333338	Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease
Q37076798	Selective versus total insulin resistance: a pathogenic paradox
Q24630811	Self-assembling enzymes and the origins of the cytoskeleton
Q92012498	Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
Q38320938	Sequence analysis and map assignment of pig SREBF2 and ADFP.
Q28511724	Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
Q53536436	Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients.
Q45968663	Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis.
Q40942950	Sfrp2 is a transcriptional target of SREBP-1 in mouse chondrogenic cells.
Q28395865	Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome
Q38331700	Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice.
Q30404667	Side-chain oxysterols: from cells to membranes to molecules
Q38111226	Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.
Q36939995	Signaling mechanisms in alcoholic liver injury: role of transcription factors, kinases and heat shock proteins
Q90589491	Signaling networks in immunometabolism
Q36485655	Signalling mechanisms linking hepatic glucose and lipid metabolism
Q37010826	Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population
Q35946066	Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis
Q37604358	Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL-loaded macrophages
Q35927740	Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA reductase
Q35116087	Single nucleotide polymorphism of SREBF-1 gene associated with an increased risk of endometrial cancer in Chinese women
Q43116362	Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells
Q26828939	Sirtuins as regulators of metabolism and healthspan
Q24548362	Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
Q37976307	Sirtuins mediate mammalian metabolic responses to nutrient availability
Q37338987	Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
Q49201010	Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
Q51244786	Social status affects lipid metabolism in rainbow trout, Oncorhynchus mykiss.
Q80026860	Some bovine proteins behave as dietary fibres and reduce serum lipids in rats
Q29619334	Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
Q31157296	Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer
Q28483866	Spatial distribution of the pathways of cholesterol homeostasis in human retina
Q89256466	Specific Amino Acids Affect Cardiovascular Diseases and Atherogenesis via Protection against Macrophage Foam Cell Formation: Review Article
Q28302753	Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway
Q47787270	Srebp-controlled glucose metabolism is essential for NK cell functional responses
Q35118561	StAR-related Lipid Transfer (START) Proteins: Mediators of Intracellular Lipid Metabolism
Q64376813	Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling
Q37091619	Statin Effects to Reduce Hepatosteatosis as Measured by Computed Tomography in Patients With Human Immunodeficiency Virus
Q37704226	Statin prescribing for people with severe mental illnesses: a staggered cohort study of 'real-world' impacts.
Q64062792	Statins and Inflammation: New Therapeutic Opportunities in Psychiatry
Q80002035	Statins and hepatic steatosis: perspectives from the Dallas Heart Study
Q43179430	Statins and primary prevention: is all the evidence in?
Q30446668	Statins in liver disease: a molehill, an iceberg, or neither?
Q35071237	Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
Q45223740	Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet
Q33907632	Steatosis and steatohepatitis: complex disorders
Q38165140	Steatosis in the liver.
Q57072613	Sterol Metabolism and Transport in Atherosclerosis and Cancer
Q38761124	Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1
Q64063164	Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Q28511448	Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
Q34425982	Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium
Q34519994	Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Q47442591	Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
Q34121467	Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
Q37608436	Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver
Q39798905	Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity
Q36839721	Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Q33635793	Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells
Q35119794	Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells
Q37372255	Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells
Q24683936	Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
Q46884435	Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
Q38607566	Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion.
Q38985926	Strategies to limit immune-activation in HIV patients.
Q57064243	Structural Proteins of HCV and Biological Functions
Q36845708	Structure and function of the atypical orphan nuclear receptor small heterodimer partner
Q35291854	Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.
Q35104849	Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach
Q96224669	Subcellular diversion of cholesterol by gain- and loss-of-function mutations in PMP22
Q37125772	Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth
Q42703553	Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro
Q51042606	Sulfated polysaccharides from Enteromorpha prolifera suppress SREBP-2 and HMG-CoA reductase expression and attenuate non-alcoholic fatty liver disease induced by a high-fat diet.
Q34542885	Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells
Q35077610	Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1.
Q94464349	Supplemental Clostridium butyricum Modulates Lipid Metabolism Through Shaping Gut Microbiota and Bile Acid Profile of Aged Laying Hens
Q38752313	Supplementation with linoleic acid-rich soybean oil stimulates macrophage foam cell formation via increased oxidative stress and diacylglycerol acyltransferase1-mediated triglyceride biosynthesis
Q34614493	Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice
Q41180864	Suppression of PGC-1alpha by Ethanol: Implications of Its Role in Alcohol Induced Liver Injury.
Q38745464	Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation
Q36574008	Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line.
Q55482080	Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.
Q33716026	Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
Q42980095	Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements.
Q97643595	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Q57012097	Systems Biology in Human Health and Disease
Q47262709	Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines
Q38226358	Systems biology strategies to study lipidomes in health and disease.
Q37116046	TAK1 regulates hepatic lipid homeostasis through SREBP
Q46835510	TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
Q37549846	TIFA as a crucial mediator for NLRP3 inflammasome.
Q38730344	TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway
Q37656016	Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice
Q39782322	Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss
Q43105122	Targeted lipidomic analysis of oxysterols in the embryonic central nervous system
Q37552285	Targeting Lipid Metabolic Reprogramming as Anticancer Therapeutics
Q38121980	Targeting SREBP-1-driven lipid metabolism to treat cancer
Q99712026	Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy
Q36548517	Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation
Q27014838	Targeting autophagy for the treatment of liver diseases
Q37231731	Targeting bile-acid signalling for metabolic diseases
Q92573701	Targeting extracellular nutrient dependencies of cancer cells
Q50026335	Targeting immuno-metabolism to improve anti-cancer therapies
Q90026856	Teriparatide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 Diabetes Mellitus
Q30430463	Tgif1 represses apolipoprotein gene expression in liver
Q21194859	The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
Q34357938	The A2b adenosine receptor modulates glucose homeostasis and obesity
Q41995694	The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels
Q92177891	The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata
Q57300008	The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition
Q112130067	The Association between Branched-Chain Amino Acids (BCAAs) and Cardiometabolic Risk Factors in Middle-Aged Caucasian Women Stratified According to Glycemic Status
Q52661639	The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Q42850426	The Effect of a Mutation in the 3-UTR Region of theHMGCRGene on Cholesterol in Beijing-You Chickens
Q88210352	The Endoplasmic Reticulum and the Cellular Reticular Network
Q35753820	The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells
Q37821046	The Golgi apparatus: an organelle with multiple complex functions
Q36573945	The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism
Q37216964	The Hippo pathway, p53 and cholesterol
Q33467104	The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
Q36783013	The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
Q24658039	The LDL receptor
Q37002668	The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation
Q36938987	The Mediator Complex and Lipid Metabolism
Q42085671	The MicroRNA Interaction Network of Lipid Diseases.
Q24613957	The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Q91106572	The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
Q60920750	The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins
Q90749894	The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD
Q26801471	The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAs
Q90158293	The Role of Hypoxia-Inducible Factor 1α in the Regulation of Human Meibomian Gland Epithelial Cells
Q39429872	The Role of Lipid Bodies in the Microglial Aging Process and Related Diseases
Q33831711	The Role of Lipid and Lipoprotein Metabolism in Non-Alcoholic Fatty Liver Disease
Q28068811	The Role of miRNAs in Common Inflammatory Arthropathies: Osteoarthritis and Gouty Arthritis
Q35667292	The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
Q37723259	The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
Q37562004	The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.
Q53625244	The SRE Motif in the Human PNPLA3 Promoter (-97 to -88 bp) Mediates Transactivational Effects of SREBP-1c.
Q79423649	The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population
Q34223258	The SREBP pathway--insights from Insigs and insects
Q36869039	The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
Q36487390	The Sterolgene v0 cDNA microarray: a systemic approach to studies of cholesterol homeostasis and drug metabolism.
Q89862360	The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach
Q24294805	The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways
Q92445005	The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes
Q98177451	The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction
Q35012730	The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
Q35849968	The anti-obesity effects of a tuna peptide on 3T3-L1 adipocytes are mediated by the inhibition of the expression of lipogenic and adipogenic genes and by the activation of the Wnt/β-catenin signaling pathway
Q38751170	The beneficial effects of taurine in preventing metabolic syndrome
Q24654991	The blind men 'see' the elephant-the many faces of fatty liver disease
Q34642326	The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
Q94570622	The cellular function of SCAP in metabolic signaling
Q91779435	The characteristics of glucose homoeostasis in grass carp and Chinese longsnout catfish after oral starch administration: a comparative study between herbivorous and carnivorous species of fish
Q39970114	The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells
Q34159564	The combined effect of azithromycin and insulin-like growth factor-1 on cultured human meibomian gland epithelial cells
Q37132018	The complexity of thyroid transcription factor 1 with both pro- and anti-oncogenic activities
Q34860549	The contribution of endoplasmic reticulum stress to liver diseases
Q38089090	The controversy of a wider statin utilization: why?
Q37684018	The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro
Q28583355	The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome
Q46350670	The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet
Q40621928	The effect of trans-10,cis-12 conjugated linoleic acid on lipogenesis is tissue dependent in hamsters
Q37196034	The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism
Q53817935	The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance.
Q38096735	The fat side of prostate cancer
Q38874423	The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68.
Q93164013	The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
Q47095631	The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.
Q47374423	The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation
Q37947064	The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity
Q38125222	The increasingly complex mechanism of HMG-CoA reductase.
Q30235314	The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review.
Q53090551	The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase.
Q28082012	The interplay of the gut microbiome, bile acids, and volatile organic compounds
Q49793994	The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells.
Q35866478	The liver plays a key role in whole body sterol accretion of the neonatal Golden Syrian hamster
Q35214901	The loss of Tm7sf gene accelerates skin papilloma formation in mice
Q58801216	The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain
Q37867697	The mechanistic basis for the induction of hepatic steatosis by xenobiotics
Q37264509	The miR-33 gene is identified in a marine teleost: a potential role in regulation of LC-PUFA biosynthesis in Siganus canaliculatus
Q36355502	The miRNA Interactome in Metabolic Homeostasis
Q36659049	The multifaceted role of mTORC1 in the control of lipid metabolism
Q29694341	The multifaceted roles of fatty acid synthesis in cancer
Q35224559	The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2
Q41546097	The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol efflux
Q57921401	The peroxisome: an update on mysteries 2.0
Q41352872	The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth.
Q36526198	The plaque "micro" environment: microRNAs control the risk and the development of atherosclerosis.
Q37272567	The plasma lipidomic signature of nonalcoholic steatohepatitis
Q37778758	The potential of cytokines as safety biomarkers for drug-induced liver injury
Q36004290	The role of CREB-H transcription factor in triglyceride metabolism
Q38656970	The role of bariatric surgery in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Q24597882	The role of circadian clocks in metabolic disease
Q40666587	The role of cytochrome P450 in the regulation of cholesterol biosynthesis
Q36954669	The role of dietary fat in adipose tissue metabolism.
Q38660769	The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target?
Q38321405	The role of lipin-1 in the pathogenesis of alcoholic fatty liver
Q36728983	The role of microRNAs in cholesterol efflux and hepatic lipid metabolism.
Q37061247	The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.
Q36947456	The role of protease inhibitors in the pathogenesis of HIV-associated insulin resistance: cellular mechanisms and clinical implications
Q24598812	The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications
Q34273619	The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders
Q35901803	The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
Q44237370	The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.
Q51754944	The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice.
Q28649493	The small molecule fenpropimorph rapidly converts chloroplast membrane lipids to triacylglycerols in Chlamydomonas reinhardtii
Q59789027	The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
Q37232021	The structural basis of cholesterol accessibility in membranes
Q36567141	The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response
Q41909224	The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
Q37636344	The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis
Q48274302	The utility of noninvasive scores in assessing the prevalence of nonalcoholic fatty liver disease and advanced fibrosis in type 1 diabetic patients
Q38331528	Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice
Q34069183	Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease
Q86315151	Therapy for lysosomal acid lipase deficiency: replacing a missing link
Q33861421	Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
Q93338779	Thyroid Hormone Signaling and the Liver
Q33569654	Thyroid dysfunction associated with follicular cell steatosis in obese male mice and humans
Q37230659	Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys
Q33653609	Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium
Q53638708	Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.
Q38341562	Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver
Q64880869	Tissue-specific changes in Srebf1 and Srebf2 expression and DNA methylation with perinatal phthalate exposure.
Q36725247	Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.
Q33879733	Topics in transcriptional control of lipid metabolism: from transcription factors to gene-promoter polymorphisms
Q34255878	Toward a unifying hypothesis of metabolic syndrome.
Q58793016	Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
Q36858185	Trajectory clustering: a non-parametric method for grouping gene expression time courses, with applications to mammary development
Q34789643	Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse
Q40553571	Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells
Q50217785	Transcriptional Regulation of T Cell Metabolism Reprograming
Q47160173	Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function
Q28269939	Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES
Q43540910	Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).
Q33672543	Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.
Q34721358	Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments
Q46811170	Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid
Q96228328	Transcriptional regulation mechanism of SREBP on Δ6 Fad in razor clam Sinonovacula constricta
Q28205169	Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors
Q24803245	Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell function
Q36100254	Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides
Q28551174	Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
Q41593538	Transcriptome analysis of the pectoral muscles of local chickens and commercial broilers using Ribo-Zero ribonucleic acid sequencing.
Q36187924	Transcriptome profiling identifies p53 as a key player during calreticulin deficiency: Implications in lipid accumulation
Q36500064	Transcriptome profiling unveils the role of cholesterol in IL-17A signaling in psoriasis
Q35350853	Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain
Q41753061	Transcriptomics expression analysis to unveil the molecular mechanisms underlying the cocoa polyphenol treatment in diet-induced obesity rats.
Q93051963	Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections
Q37729856	Transglycosylated Starch Improves Insulin Response and Alters Lipid and Amino Acid Metabolome in a Growing Pig Model
Q36300178	Treatment of dyslipidemia in children and adolescents
Q36360487	Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens
Q47719467	Triglyceride Metabolism in the Liver.
Q46597572	Triglyceridemia and peroxisome proliferator-activated receptor-alpha expression are not connected in fenofibrate-treated pregnant rats
Q64082852	Tropomyosin-receptor kinase fused gene (TFG) regulates lipid production in human sebocytes
Q88984016	Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation
Q38984142	Truths and controversies concerning the role of miRNAs in atherosclerosis and lipid metabolism
Q38959878	Trypanosoma cruzi infection results in an increase in intracellular cholesterol
Q36049513	Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.
Q38161749	Tumor metabolism of malignant gliomas
Q30539219	Tumor-suppressive effects of CDK8 in endometrial cancer cells.
Q24633793	Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c
Q36499261	Txnip balances metabolic and growth signaling via PTEN disulfide reduction
Q100516145	USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638
Q33644530	Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice
Q90975335	Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway
Q41765603	Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death.
Q46381784	Uncovering Structural Diversity of Unsaturated Fatty Acyls in Cholesteryl Esters via Photochemical Reaction and Tandem Mass Spectrometry.
Q47436128	Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.
Q50147891	Understanding the diversity of membrane lipid composition.
Q39246859	Unraveling the Regulation of Hepatic Metabolism by Insulin
Q36850798	Unravelling the mysterious roles of melanocortin-3 receptors in metabolic homeostasis and obesity using mouse genetics
Q42625301	Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits
Q92556677	Ursodeoxycholic Acid Alters Bile Acid and Fatty Acid Profiles in a Mouse Model of Diet-Induced Obesity
Q64109856	Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway
Q21134517	Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease
Q34916798	Viperin regulates cellular lipid metabolism during human cytomegalovirus infection
Q64355579	Visceral Obesity is Associated with High Levels of Serum Squalene*
Q34719267	Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism
Q92229282	WDR76 mediates obesity and hepatic steatosis via HRas destabilization
Q54992860	Water-Soluble Fish Protein Intake Led to Lower Serum and Liver Cholesterol Concentrations in Obese Zucker fa/fa Rats.
Q35689614	Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARα/LPL and LDLR
Q47411211	Welsh onion extract inhibits PCSK9 expression contributing to the maintenance of the LDLR level under lipid depletion conditions of HepG2 cells.
Q46355683	What Is Lipotoxicity?
Q34040303	Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses.
Q44011642	Wild blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats.
Q40114088	Wilms' tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation
Q100307286	Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis
Q38856934	Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation
Q92326983	Yarrow Supercritical Extract Ameliorates the Metabolic Stress in a Model of Obesity Induced by High-Fat Diet
Q64120997	Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer
Q28538769	Zinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolution
Q50889958	Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans.
Q53261375	[Oxysterols: metabolism, biological role and associated diseases].
Q83755659	[SREBP-1 and fatty liver. Clinical relevance for diabetes, obesity, dyslipidemia and atherosclerosis]
Q33678751	alpha(1)-fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulator
Q28115537	cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1
Q33926184	mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss
Q90647452	mTOR and Tumor Cachexia
Q92643974	mTOR at the nexus of nutrition, growth, ageing and disease
Q30425628	mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
Q38209860	mTOR signaling and transcriptional regulation in T lymphocytes
Q28252695	mTOR signaling in tumorigenesis
Q39363666	mTORC1 and mTORC2 as regulators of cell metabolism in immunity.
Q27012468	mTORC1 signaling activates NRF1 to increase cellular proteasome levels
Q39256910	mTORC1 signaling in hepatic lipid metabolism
Q35970880	miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries
Q64377093	miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA
Q52579260	miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.
Q24627398	miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Q38730644	miRNAs and High-Density Lipoprotein metabolism
Q38966905	miRNAs in non-alcoholic fatty liver disease
Q37650119	microRNA regulation of lipoprotein metabolism.
Q41034686	microRNA-29 mediates a novel negative feedback loop to regulate SCAP/SREBP-1 and lipid metabolism
Q34248289	microRNAs and HDL life cycle.
Q24634470	microRNAs and cholesterol metabolism
Q37709886	microRNAs in lipoprotein metabolism and cardiometabolic disorders.
Q35718937	p38 mitogen-activated protein kinase and liver X receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cells
Q38354871	p53 Activation in Adipocytes of Obese Mice
Q90726562	p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Q38856285	p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A.
Q43846570	β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.

review article	Q7318358
scholarly article	Q13442814

P356	DOI	10.1172/JCI0215593
		10.1172/JCI15593
P3181	OpenCitations bibliographic resource ID	354206
P932	PMC publication ID	150968
P698	PubMed publication ID	11994399

P2093	author name string	Goldstein JL
		Brown MS
		Horton JD
P2860	cites work	Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcription	Q64379685
		Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver	Q77696898
		Role of AMP-activated protein kinase in mechanism of metformin action	Q22241898
		Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta	Q24553340
		Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells	Q24561820
		Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta	Q24598068
		Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice	Q28144106
		Nonalcoholic fatty liver disease: a feature of the metabolic syndrome	Q28208772
		Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors	Q28215527
		The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor	Q28238069
		Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein	Q28295187
		SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation	Q28365331
		ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose	Q28583495
		Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene	Q28584842
		Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins	Q28585597
		Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene	Q28588943
		Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes	Q28646399
		Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins	Q28646552
		Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells	Q31582971
		Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay	Q31742604
		Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis	Q33635172
		Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL	Q33849024
		Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes	Q33878155
		Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B	Q34047812
		Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands	Q34083979
		Regulation of gene expression by SREBP and SCAP.	Q34101197
		Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2.	Q34405624
		Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.	Q34451430
		Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis	Q34497858
		Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.	Q35926317
		Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes	Q36698641
		Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver	Q36806480
		Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element	Q37254332
		Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a	Q37360326
		Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells	Q37364195
		Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice	Q37375695
		Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.	Q37382401
		Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).	Q37388151
		Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis	Q38298207
		Metformin reverses fatty liver disease in obese, leptin-deficient mice	Q38308602
		Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus	Q38319698
		Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene	Q40864894
		Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats	Q40937102
		Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.	Q43778752
		Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c	Q43848640
		Functional analysis of secreted and transmembrane proteins critical to mouse development.	Q46905044
		Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.	Q52895402
P433	issue	9
P407	language of work or name	English	Q1860
P921	main subject	fatty acid	Q61476
		sterol response element binding	Q21112287
P304	page(s)	1125-31
P577	publication date	2002-05-01
P1433	published in	Journal of Clinical Investigation	Q3186904
P1476	title	SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
P478	volume	109

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

scientific article (publication date: May 2002)

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