Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish

scientific article published on 07 February 2020

Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/TOXINS12020107
P932PMC publication ID7076763
P698PubMed publication ID32046144

P2093author name stringLi Li
Dapeng Li
Dandan Zhang
Wang Lin
Rong Tang
Liping Yang
Honghui Guo
Lingkai Wang
Yinjie Liu
P2860cites workMicrocystins associated with Microcystis dominated blooms in the Southwest wetlands, Western AustraliaQ39748196
Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activationQ42138693
A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritanceQ42176881
Microcystin-LR induced thyroid dysfunction and metabolic disorders in miceQ42703216
Hepatic histopathological characteristics and antioxidant response of phytoplanktivorous silver carp intraperitoneally injected with extracted microcystinsQ43233165
Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in miceQ44454610
Transfer, tissue distribution and bioaccumulation of microcystin LR in the phytoplanktivorous and carnivorous fish in Anzali wetland, with potential health risks to humansQ46482865
Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large, shallow, eutrophic Dianchi LakeQ46842668
The synergistic effects of waterborne microcystin-LR and nitrite on hepatic pathological damage, lipid peroxidation and antioxidant responses of male zebrafishQ47208252
Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells.Q47358827
Hepatic positive and negative antioxidant responses in zebrafish after intraperitoneal administration of toxic microcystin-LR.Q51071968
Metabolic response to oral microcystin-LR exposure in the rat by NMR-based metabonomic study.Q51545871
Factors Affecting Temporal and Spatial Variations of Microcystins in Gonghu Bay of Lake Taihu, with Potential Risk of Microcystin Contamination to Human HealthQ51619730
Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms.Q51666460
Sequential ultrastructural and biochemical changes induced in vivo by the hepatotoxic microcystins in liver of the phytoplanktivorous silver carp Hypophthalmichthys molitrix.Q51706825
Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved.Q52666362
Endoplasmic reticulum stress and disturbed calcium homeostasis are involved in copper-induced alteration in hepatic lipid metabolism in yellow catfish Pelteobagrus fulvidraco.Q53266566
Microcystin-LR altered mRNA and protein expression of endoplasmic reticulum stress signaling molecules related to hepatic lipid metabolism abnormalities in mice.Q53460343
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
In vivo studies on toxin accumulation in liver and ultrastructural changes of hepatocytes of the phytoplanktivorous bighead carp i.p.-injected with extracted microcystinsQ81015858
Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell lineQ83731120
ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell deathQ84099274
Endoplasmic reticulum stress in murine liver and kidney exposed to microcystin-LRQ84625272
Occurrence and spatial distributions of microcystins in Poyang Lake, the largest freshwater lake in ChinaQ85302199
Time-dependent effects of waterborne copper exposure influencing hepatic lipid deposition and metabolism in javelin goby Synechogobius hasta and their mechanismQ87491236
Estrogenic potency of MC-LR is induced via stimulating steroidogenesis: In vitro and in vivo evidenceQ88717537
High-fat diet induces aberrant hepatic lipid secretion in blunt snout bream by activating endoplasmic reticulum stress-associated IRE1/XBP1 pathwayQ90542247
A Review on the Study of Cyanotoxins in Paleolimnological Research: Current Knowledge and Future NeedsQ92157071
Cyanobacteria blooms and non-alcoholic liver disease: evidence from a county level ecological study in the United StatesQ21146668
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafishQ28539163
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genesQ28646418
Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesityQ28828479
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR.Q31150691
Distribution of microcystin-producing and non-microcystin-producing Microcystis sp. in European freshwater bodies: detection of microcystins and microcystin genes in individual coloniesQ33208007
Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditionsQ33208776
Biochemical and ultrastructural changes of the liver and kidney of the phytoplanktivorous silver carp feeding naturally on toxic Microcystis blooms in Taihu Lake, ChinaQ33281314
Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR.Q33992237
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plantsQ34188529
The dynamics of microcystis genotypes and microcystin production and associations with environmental factors during blooms in Lake Chaohu, ChinaQ34792560
Human intoxication by microcystins during renal dialysis treatment in Caruaru-BrazilQ35035605
The impact of the unfolded protein response on human diseaseQ36062081
Critical Role of Endoplasmic Reticulum Stress in Cognitive Impairment Induced by Microcystin-LR.Q36403924
The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox controlQ36598776
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic diseaseQ36910684
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?Q36989869
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
The role of the lipogenic pathway in the development of hepatic steatosis.Q37386081
Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.Q37696792
Molecular aspects of microcystin-induced hepatotoxicity and hepatocarcinogenesis.Q37730716
The Role of Lipid Metabolism in the Pathogenesis of Alcoholic and Nonalcoholic Hepatic SteatosisQ37801599
Endoplasmic reticulum stress and lipid dysregulationQ37834712
Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafishQ39135063
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectendoplasmic reticulumQ79927
P577publication date2020-02-07
P1433published inToxinsQ15724569
P1476titleChronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish
P478volume12

Reverse relations

Q90047443Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitiscites workP2860

Search more.