Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome

scientific article published on 27 September 2016

Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.759795
P932PMC publication ID5104945
P698PubMed publication ID27679530

P2093author name stringJames L McManaman
David J Orlicky
Andrew E Libby
Elise Bales
P2860cites workThe Obesity EpidemicQ22252322
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaQ24598068
Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepQ24655209
Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cellsQ28116233
Lipid droplets in lipogenesis and lipolysisQ28265077
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6Q37163041
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivoQ37267126
From the metabolic syndrome to NAFLD or vice versa?Q37703968
Roles of PPARs in NAFLD: potential therapeutic targetsQ37953148
Stearoyl CoA desaturase 1: role in cellular inflammation and stressQ37972614
Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trialsQ37978785
ATP-citrate lyase: a mini-review.Q38009130
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosisQ38090905
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elementsQ38295025
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.Q38297724
Lipid-dependent regulation of the unfolded protein responseQ38301758
Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.Q38302026
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppressionQ38347368
Decrease in membrane phospholipid unsaturation induces unfolded protein responseQ41868507
Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction.Q42216030
Srebp2: A master regulator of sterol and fatty acid synthesisQ42591209
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanismsQ45300618
Membrane lipid saturation activates IRE1α without inducing clusteringQ46157031
A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegansQ47069457
PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice.Q51798503
Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion.Q53523154
Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.Q54390800
Elovl6 promotes nonalcoholic steatohepatitisQ58207361
Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomesQ69827876
Effects of a high-fat diet on energy metabolism and ROS production in rat liverQ82615002
Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitisQ85307305
Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathwaysQ28576771
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant miceQ28591122
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genesQ28646399
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Molecular mediators of hepatic steatosis and liver injuryQ29616709
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cellsQ31582971
Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western dietQ33584753
Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterolQ33731981
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisQ33734679
Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cellsQ33778696
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J miceQ33825040
Regulation of basal cellular physiology by the homeostatic unfolded protein responseQ33886820
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesQ33918445
Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyteQ33923114
Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient miceQ33993281
Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related proteinQ34302451
Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver diseaseQ34357996
Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soilQ34636643
Elovl6: a new player in fatty acid metabolism and insulin sensitivityQ34658185
Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolismQ35006878
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alphaQ35209149
Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotectionQ35867161
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
SREBPs: sterol-regulated transcription factorsQ36416721
Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese miceQ36462135
Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expressionQ36473631
Pathophysiology of lipid droplet proteins in liver diseasesQ36553968
Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradationQ36579588
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.Q36725247
Docosahexaenoic acid (DHA) and hepatic gene transcriptionQ36725271
Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver diseaseQ36754811
Inhibition of ADRP prevents diet-induced insulin resistanceQ36877282
Hepatic triglyceride synthesis and nonalcoholic fatty liver diseaseQ37156321
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)24231-24246
P577publication date2016-09-27
P1433published inJournal of Biological ChemistryQ867727
P1476titlePerilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome
P478volume291

Reverse relations

cites work (P2860)
Q64084143Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model
Q89790021Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice
Q90390497Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2
Q93078660Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2
Q90638448Hepatic Proteomic Changes and Sirt1/AMPK Signaling Activation by Oxymatrine Treatment in Rats With Non-alcoholic Steatosis
Q57807657Molecular pathways of nonalcoholic fatty liver disease development and progression
Q57027990Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy
Q50152028New Method for Quantitation of Lipid Droplet Volume From Light Microscopic Images With an Application to Determination of PAT Protein Density on the Droplet Surface.
Q91386361New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery
Q88984043Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature
Q40064092Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine
Q90402623Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions
Q92544525Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device
Q90410771The Effect of Silibinin on Protein Expression Profile in White Adipose Tissue of Obese Mice
Q47813075The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis
Q58604344miR-26a Potentially Contributes to the Regulation of Fatty Acid and Sterol Metabolism In Vitro Human HepG2 Cell Model of Nonalcoholic Fatty Liver Disease

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