Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection

scientific article published on 13 September 2013

Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BIOCHI.2013.08.026
P932PMC publication ID4507817
P698PubMed publication ID24036367

P2093author name stringCarole Sztalryd
Alan R Kimmel
P2860cites workGlobal nutrition transition and the pandemic of obesity in developing countriesQ24610026
Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contractionQ24633595
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteinsQ24652679
Mechanisms of gene regulation by fatty acidsQ26863658
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytesQ27676771
Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and DictyosteliumQ28206070
Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gammaQ28258734
The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an α-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humansQ28289312
COPI complex is a regulator of lipid homeostasisQ28474150
Interactions of perilipin-5 (Plin5) with adipose triglyceride lipaseQ28505780
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesityQ28507768
Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidationQ28508596
Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteinsQ28508829
The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondriaQ28568815
CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndromeQ28573006
Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondriaQ28579160
Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunctionQ28589187
Functional genomic screen reveals genes involved in lipid-droplet formation and utilizationQ30489849
Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL.Q33412995
PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.Q33641441
Perilipin overexpression in mice protects against diet-induced obesityQ33784642
Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient miceQ33993281
Adipocyte protein S3-12 coats nascent lipid dropletsQ34211114
Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related proteinQ34302451
Hormone-sensitive lipase modulates adipose metabolism through PPARγ.Q34386313
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioningQ34511046
Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat storesQ34543395
Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated proteinQ34962974
Obesity, insulin resistance and free fatty acidsQ35204838
Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glandsQ35227486
The phospholipid monolayer associated with perilipin-enriched lipid droplets is a highly organized rigid membrane structureQ35543625
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysisQ35591725
Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?Q35596985
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sitesQ35621038
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.Q35630386
FAT SIGNALS--lipases and lipolysis in lipid metabolism and signalingQ35859576
Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in miceQ35900825
Role of PAT proteins in lipid metabolismQ36055789
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supplyQ36127114
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestrationQ36139803
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activationQ36323578
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets.Q36350836
A proposed model of fat packaging by exchangeable lipid droplet proteinsQ36589548
Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrierQ36709594
AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevanceQ36711158
Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver diseaseQ36754811
Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in miceQ36763933
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid dropletsQ36791060
Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance.Q36807686
Inhibition of ADRP prevents diet-induced insulin resistanceQ36877282
Role of intramyocelluar lipids in human healthQ37007425
Distinct cellular pools of perilipin 5 point to roles in lipid traffickingQ37087938
Lipid droplets and cellular lipid metabolismQ37157015
Perilipin deficiency and autosomal dominant partial lipodystrophyQ37173608
Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage dropletQ37198922
Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activityQ37297861
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.Q37400732
Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilizationQ37431405
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.Q37435661
Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl).Q37454139
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5.Q37463574
Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity.Q37851652
The dynamic roles of intracellular lipid droplets: from archaea to mammals.Q37946280
Dissociating fatty liver and diabetesQ38050214
Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.Q38302026
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.Q38332175
Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytesQ40206456
Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.Q40295805
FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.Q41227900
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferasesQ41818160
Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulationQ42014071
Fatty acids regulate perilipin5 in muscle by activating PPARδQ42130623
Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) miceQ42496745
Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnoverQ42518879
The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient originQ42661737
Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytesQ42800102
The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage dropletsQ42806585
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storageQ42824398
Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytesQ42826631
Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile.Q44631801
Determination of lipolysis in isolated primary adipocytesQ46564244
Role of caveolin-1 in the modulation of lipolysis and lipid droplet formationQ47690607
Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation.Q51386115
Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols.Q51840956
Differential association of adipophilin and TIP47 proteins with cytoplasmic lipid droplets in mouse enterocytes during dietary fat absorptionQ84447769
P407language of work or nameEnglishQ1860
P304page(s)96-101
P577publication date2013-09-13
P1433published inBiochimieQ2904035
P1476titlePerilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection
P478volume96

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