Role of intramyocelluar lipids in human health

scientific article published on 20 June 2012

Role of intramyocelluar lipids in human health is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TEM.2012.05.009
P932PMC publication ID4908975
P698PubMed publication ID22721584
P5875ResearchGate publication ID227856133

P50authorPaul M. CoenQ40515444
P2093author name stringBret H Goodpaster
P2860cites workSubcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscleQ82105944
Adipophilin distribution and colocalization with lipid droplets in skeletal muscleQ83239370
TIP47 functions in the biogenesis of lipid dropletsQ24648200
Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gammaQ28258734
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained stateQ28271737
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistanceQ28291556
Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondriaQ28473405
Interactions of perilipin-5 (Plin5) with adipose triglyceride lipaseQ28505780
Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscleQ28743514
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetesQ29616567
The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysisQ29618429
Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistanceQ30479891
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cellsQ31833471
Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide contentQ33556682
Ceramide in the eukaryotic stress responseQ33826715
The biogenesis and functions of lipid bodies in animals, plants and microorganismsQ34084932
Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humansQ34099337
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipaseQ34369246
Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjectsQ34414178
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolitesQ34476883
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioningQ34511046
Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women.Q34573330
Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?Q34863680
Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated proteinQ34962974
Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humansQ35043414
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.Q35107592
Many ceramides.Q35149996
Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?Q35227175
Energy balance in obesityQ35542227
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.Q35630386
Skeletal muscle membrane lipid composition is related to adiposity and insulin actionQ35768477
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistanceQ35785732
Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans.Q35812810
FAT SIGNALS--lipases and lipolysis in lipid metabolism and signalingQ35859576
Proposed mechanisms for the induction of insulin resistance by oxidative stressQ36342638
Assessment of intramuscular triglycerides: contribution to metabolic abnormalitiesQ36567244
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipaseQ36858543
Inhibition of ADRP prevents diet-induced insulin resistanceQ36877282
Muscular diacylglycerol metabolism and insulin resistanceQ37061303
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistanceQ37105295
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequencesQ37147602
Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overviewQ37176589
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisitedQ37246314
Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.Q37246341
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.Q37435661
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic diseaseQ37677929
The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?Q37710735
The twists and turns of sphingolipid pathway in glucose regulationQ37766367
Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusionQ39275889
Proteome of skeletal muscle lipid droplet reveals association with mitochondria and apolipoprotein a-I.Q39483811
Intramuscular lipid content is increased in obesity and decreased by weight lossQ39535127
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistanceQ40028148
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.Q40541165
Regional adiposity and morbidityQ40638635
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumptionQ41119321
The Relative Value of Fat and Carbohydrate as Sources of Muscular Energy: With Appendices on the Correlation between Standard Metabolism and the Respiratory Quotient during Rest and WorkQ42103078
The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols.Q42209658
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humansQ42247172
Ceramide content is increased in skeletal muscle from obese insulin-resistant humansQ42454790
1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.Q42481698
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissueQ42809801
Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscleQ42997638
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletesQ43819832
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaQ44043178
Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjectsQ44155508
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acidsQ44276635
Skeletal muscle lipid metabolism with obesityQ44355154
Effects of Plasma Adrenaline on Hormone‐Sensitive Lipase at Rest and during Moderate Exercise in Human Skeletal MuscleQ44429405
Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted stateQ44599993
Intramyocellular lipid changes in men and women during aerobic exercise: a (1)H-magnetic resonance spectroscopy studyQ44690205
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.Q44888045
Different mechanisms can alter fatty acid transport when muscle contractile activity is chronically alteredQ44894359
Impaired beta-adrenergically mediated lipolysis in skeletal muscle of obese subjectsQ45016991
Utilization of blood-borne and intramuscular substrates during continuous and intermittent exercise in man.Q45052842
Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans.Q45926251
Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.Q45929279
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity.Q46610480
Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake.Q46752458
Evaluation of exercise and training on muscle lipid metabolismQ46764668
Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid contentQ46770144
Skeletal muscle lipid oxidation and obesity: influence of weight loss and exerciseQ47248288
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunctionQ48117471
Skeletal muscle fatty acid handling in insulin resistant men.Q51379022
High triacylglycerol turnover rate in human skeletal muscle.Q51526573
Concentration of Triglycerides, Phospholipids and Glycogen in Skeletal Muscle and of Free Fatty Acids and β-Hydroxybutyric Acid in Blood in Man in Response to ExerciseQ51682889
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.Q54095921
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen SpeciesQ58116814
Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise trainingQ59515950
Ceramide Interaction with the Respiratory Chain of Heart Mitochondria†Q59626875
A single prior bout of exercise protects against palmitate-induced insulin resistance despite an increase in total ceramide contentQ63805130
Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detrainingQ63805327
Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specificQ73086336
Kinetics of intramuscular triglyceride fatty acids in exercising humansQ73128173
Functional differences in lipid metabolism in resting skeletal muscle of various fiber typesQ73281995
Exercise training increases lipid metabolism gene expression in human skeletal muscleQ74308831
Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36Q77306883
Fatty acid oxidation by skeletal muscle during rest and activityQ78262586
Impaired plasma fatty acid oxidation in extremely obese womenQ80388621
P433issue8
P921main subjectlipidQ11367
P304page(s)391-398
P577publication date2012-06-20
P1433published inTrends in Endocrinology and MetabolismQ15265727
P1476titleRole of intramyocelluar lipids in human health
P478volume23

Reverse relations

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