| P50 | author | John R Ussher | Q91702545 |
| P2093 | author name string | Rami Al Batran | |
| | Hanin Aburasayn | |
| P2860 | cites work | Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation | Q24320259 |
| | The sphingolipid salvage pathway in ceramide metabolism and signaling | Q24642219 |
| | Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome | Q24648112 |
| | Adiponectin, driver or passenger on the road to insulin sensitivity? | Q26827971 |
| | Regulation of the intrinsic apoptosis pathway by reactive oxygen species | Q26995793 |
| | A review of ceramide analogs as potential anticancer agents | Q27009351 |
| | A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids | Q44276635 |
| | Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice | Q45182276 |
| | Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice | Q46494803 |
| | Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. | Q46610480 |
| | CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance | Q46828201 |
| | Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation | Q46917003 |
| | Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance | Q47431942 |
| | Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction | Q47877695 |
| | Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-product signaling in a ceramide-dependent manner. | Q50587751 |
| | Cis-9, trans-11 and trans-10, cis-12 CLA mixture does not change body composition, induces insulin resistance and increases serum HDL cholesterol level in rats. | Q50992763 |
| | Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity. | Q51560189 |
| | Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. | Q51754304 |
| | Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat. | Q53573537 |
| | N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells. | Q53813126 |
| | Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation | Q58116631 |
| | Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species | Q58116814 |
| | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells | Q27316876 |
| | A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance | Q28240815 |
| | Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity | Q28287290 |
| | Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance | Q28291556 |
| | Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes | Q28375279 |
| | Lactosylceramide contributes to mitochondrial dysfunction in diabetes | Q28390671 |
| | Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis | Q28547365 |
| | Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 | Q29555853 |
| | Mechanisms for insulin resistance: common threads and missing links | Q29620447 |
| | Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity | Q30423827 |
| | Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods | Q33326845 |
| | Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content | Q33556682 |
| | Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis | Q33944689 |
| | Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice | Q34178121 |
| | Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis | Q34485836 |
| | Ceramide kinase promotes tumor cell survival and mammary tumor recurrence | Q34846801 |
| | Enhanced insulin sensitivity in mice lacking ganglioside GM3. | Q34870497 |
| | Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway | Q34889125 |
| | Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis | Q35080715 |
| | Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. | Q35101294 |
| | Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes? | Q35227175 |
| | Ceramides as modulators of cellular and whole-body metabolism | Q35484864 |
| | TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation. | Q35587192 |
| | Apoptosis as a novel target for cancer chemoprevention | Q35764217 |
| | Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance | Q35785732 |
| | Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality | Q35817986 |
| | Lipid-induced mitochondrial stress and insulin action in muscle | Q35947486 |
| | Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis | Q36006997 |
| | Novel apoptosis inducing agents in cancer therapy | Q36020781 |
| | Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex | Q36047487 |
| | Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo. | Q36186252 |
| | Ceramide-enriched membrane domains | Q36286893 |
| | Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure | Q36298248 |
| | Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice | Q36410748 |
| | Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance | Q36560514 |
| | Acid sphingomyelinase is required for lipid Raft TLR4 complex formation | Q40155108 |
| | Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling | Q40445604 |
| | Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. | Q40541165 |
| | Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells | Q40546613 |
| | Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. | Q40818302 |
| | Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways | Q41022856 |
| | Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption | Q41119321 |
| | Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase | Q41197168 |
| | Stress-induced apoptosis and the sphingomyelin pathway | Q41439606 |
| | Ceramide and insulin resistance: how should the issue be approached? | Q41533503 |
| | Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. | Q41813859 |
| | Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes | Q41998928 |
| | Ceramide content is increased in skeletal muscle from obese insulin-resistant humans | Q42454790 |
| | Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate | Q42476162 |
| | Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts | Q42494101 |
| | Implication of sphingomyelin/ceramide molar ratio on the biological activity of sphingomyelinase | Q42731878 |
| | Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria? | Q42806473 |
| | Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide | Q42820917 |
| | Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes | Q43719975 |
| | Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes | Q43819832 |
| | Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease | Q44037507 |
| | Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. | Q36623114 |
| | Ceramide is a cardiotoxin in lipotoxic cardiomyopathy | Q36870574 |
| | An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice | Q36886578 |
| | Myocardial AKT: the omnipresent nexus | Q36908289 |
| | Role of intramyocelluar lipids in human health | Q37007425 |
| | Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance | Q37066869 |
| | The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes | Q37082247 |
| | Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited | Q37246314 |
| | Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. | Q37246341 |
| | Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate | Q37515719 |
| | Plasma dihydroceramide species associate with waist circumference in Mexican American families | Q37569388 |
| | The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation | Q37764369 |
| | Ceramide kinase: The first decade | Q37812793 |
| | Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart. | Q37831555 |
| | Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death | Q37894799 |
| | A ceramide-centric view of insulin resistance | Q38007631 |
| | The endoplasmic reticulum-mitochondria connection: one touch, multiple functions. | Q38161252 |
| | The role of cardiac lipotoxicity in the pathogenesis of diabetic cardiomyopathy | Q38189488 |
| | Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE | Q38265601 |
| | Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | Q38297724 |
| | Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk | Q38310300 |
| | Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression | Q38331015 |
| | Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids | Q38405034 |
| | Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes | Q38421618 |
| | Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes | Q38435916 |
| | Ceramides - Lipotoxic Inducers of Metabolic Disorders | Q38594138 |
| | Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms. | Q38598747 |
| | Lipotoxicity in obesity and diabetes-related cardiac dysfunction | Q38743024 |
| | Palmitate-induced impairments of β-cell function are linked with generation of specific ceramide species via acylation of sphingosine | Q38925949 |
| | Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle | Q39013537 |
| | Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle. | Q39090640 |
| | Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. | Q39575996 |
| | Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. | Q39940319 |
| | PKB/Akt inhibits ceramide-induced apoptosis in neuroblastoma cells by blocking apoptosis-inducing factor (AIF) translocation | Q40138760 |
| P433 | issue | 2 | |
| P921 | main subject | ceramides | Q424213 |
| | obesity | Q12174 |
| P304 | page(s) | E423-35 | |
| P577 | publication date | 2016-07-05 | |
| P1433 | published in | American Journal of Physiology - Endocrinology and Metabolism | Q15765671 |
| P1476 | title | Targeting ceramide metabolism in obesity | |
| P478 | volume | 311 | |