Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

scientific article

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1994PNAS...91...73J
P356DOI10.1073/PNAS.91.1.73
P932PMC publication ID42888
P698PubMed publication ID8278410
P5875ResearchGate publication ID14921703

P2093author name stringS Grant
W D Jarvis
D A Gewirtz
F A Fornari
R S Traylor
R N Kolesnick
P2860cites workTumor necrosis factor. New insights into the molecular mechanisms of its multiple actionsQ28281475
Cell death: the significance of apoptosisQ29617620
Establishment and characterization of a human histiocytic lymphoma cell line (U-937)Q29619570
Apoptosis: a different type of cell deathQ36001462
Improved microfluorometric DNA determination in biological material using 33258 HoechstQ36895188
The two different receptors for tumor necrosis factor mediate distinct cellular responsesQ37609601
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alphaQ37617716
Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cellsQ38315795
Continuous growth and differentiation of human myeloid leukaemic cells in suspension cultureQ40512568
Apoptosis: the biochemistry and molecular biology of programmed cell deathQ40822802
Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cellsQ41117610
Tumor necrosis factor alpha stimulates sphingomyelinase through the 55 kDa receptor in HL-60 cellsQ41589196
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.Q41594204
Ceramide stimulates a cytosolic protein phosphataseQ41635180
Analysis of TNF alpha-induced DNA strand breaks at the single cell levelQ41671477
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiationQ41700006
Double-stranded RNA and bacterial lipopolysaccharide enhance sensitivity to TNF-alpha-mediated cell deathQ41751228
Tumor necrosis factor induced DNA fragmentation of HL-60 cellsQ44647308
Biochemical lesions in DNA associated with the antiproliferative effects of mitoxantrone in the hepatoma cellQ44982769
Evidence for inhibition of growth related to compromised DNA synthesis in the interaction of daunorubicin with H-35 rat hepatomaQ45078254
The role of macrophage-derived TNFa in the induction of sublethal tumor cell DNA damageQ53492974
A simple, rapid, and sensitive DNA assay procedureQ56879279
Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free SystemQ67487070
The type B receptor for tumor necrosis factor-alpha mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cellsQ67858340
Activation of Programmed Cell Death by Recombinant Human Tumor Necrosis Factor Plus Topoisomerase II - Targeted Drugs in L929 Tumor CellsQ67913308
Induction of differentiation by tumour necrosis factor in HL-60 cells is associated with the formation of large DNA fragmentsQ68072858
Programmed cell death induced by ceramideQ70619078
A fluorescence enhancement assay for cellular DNA damageQ72952812
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
DNA damageQ5205747
P1104number of pages5
P304page(s)73-77
P577publication date1994-01-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInduction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway
P478volume91

Reverse relations

cites work (P2860)
Q396084885,7,3'-Trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway
Q36835151A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Q42155614Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.
Q42555356Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.
Q43615470Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine
Q41083675Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein
Q41121005Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicity
Q28378813Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells
Q39877642Altered susceptibility to tumor necrosis factor alpha-induced apoptosis of mouse cells expressing polyomavirus middle and small T antigens.
Q36321788Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
Q36100979An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis
Q35048574Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review
Q38491199Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production
Q42809594Apoptosis observed in BALB/3T3 cells having ingested Staphylococcus aureus
Q46066832Apoptosis: A Functional Paradigm for Programmed Plant Cell Death Induced by a Host-Selective Phytotoxin and Invoked during Development
Q41118406Apoptosis: inhibitor or instigator of carcinogenesis?
Q41440948Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.
Q42116168Attenuation of p53 expression and Bax down-regulation during phorbol ester mediated inhibition of apoptosis
Q28142107Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3
Q46943268Bax induces cytochrome c release by multiple mechanisms in mitochondria from MCF7 cells
Q28588677Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
Q41740220Biochemical and molecular mechanisms regulating apoptosis
Q33613710Biochemical studies on sphingolipid of Artemia franciscana (I) isolation and characterization of sphingomyelin.
Q41103248Biochemistry of cell death
Q31720527C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line
Q46883020Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs
Q43570501Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia
Q40789752Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.
Q41261303Cellular and molecular mechanisms underlying IL-12-induced tumor regression
Q41232357Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death
Q48167130Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease
Q47982280Ceramide activates NFkappaB by inducing the processing of p105.
Q24646262Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations
Q35047136Ceramide in apoptosis: an overview and current perspectives
Q42477793Ceramide increases steroid hormone production in MA-10 Leydig cells
Q33178433Ceramide induces apoptosis to immature cerebellar granule cells in culture
Q40877017Ceramide induces cell death in the human prostatic carcinoma cell lines PC3 and DU145 but does not seem to be involved in Fas-mediated apoptosis.
Q42948037Ceramide inhibits antigen uptake and presentation by dendritic cells
Q40241323Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells.
Q38940741Ceramide participates in lysosome-mediated cell death induced by type II anti-CD20 monoclonal antibodies
Q41727820Ceramide path in human lung cell death
Q37619251Ceramide signaling in mammalian epidermis
Q28295232Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
Q49049885Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone-induced maturation
Q43201396Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells
Q44059913Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis
Q77402834Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism
Q36364921Ceramide: a signal for apoptosis or mitogenesis?
Q77448881Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells
Q41515353Chemotherapy-induced apoptosis
Q43560214Coupling of cholesterol and cone-shaped lipids in bilayers augments membrane permeabilization by the cholesterol-specific toxins streptolysin O and Vibrio cholerae cytolysin
Q36376514Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway
Q40795317Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line
Q41065043Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis
Q73544255Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology
Q41079756Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts
Q55477999Dihydroheptaprenyl and dihydrodecaprenyl monophosphates induce apoptosis mediated by activation of caspase-3-like protease.
Q40948109Distinct effects of ceramide-generating pathways in prostate adenocarcinoma cells
Q39577917Distinct pathways for tumor necrosis factor alpha and ceramides in human cytomegalovirus infection.
Q40578192Distinct stress and cell destruction pathways are engaged by TNF and ceramide during apoptosis of MCF-7 cells
Q77780124Diversity and complexity of ceramide signalling in apoptosis
Q35758289Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis
Q41238109Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2.
Q45082385Effect of aminoethylcysteine ketimine decarboxylated dimer, a natural sulfur compound present in human plasma, on tert-butyl hydroperoxide-induced oxidative stress in human monocytic U937 cells.
Q77741344Effect of caffeic acid on tert-butyl hydroperoxide-induced oxidative stress in U937
Q38345628Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes
Q74133496Endogenous glucocorticoids decrease the acinar cell sensitivity to apoptosis during cerulein pancreatitis in rats
Q47635914Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination.
Q44163225Erucylphosphocholine-induced apoptosis in glioma cells: involvement of death receptor signalling and caspase activation
Q41049552Evidence that photodynamic stress kills Zellweger fibroblasts by a nonapoptotic mechanism
Q41454998Fas receptor (CD95)-mediated apoptosis in leukemic cells
Q36654745Fas-induced apoptosis of T cells occurs independently of ceramide generation
Q37657402Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells
Q28139356Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo
Q39757810Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
Q77374986Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats
Q74508056HPTLC analysis of sphingomylein, ceramide and sphingosine in ischemic/reperfused rat heart
Q47921342Heat shock protein 72 modulates pathways of stress-induced apoptosis.
Q44060037High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells
Q40022032Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells
Q36789696In vitro detection of apoptotic stimuli by use of the HL-60 myeloid leukemic cell line.
Q41078305Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status
Q41272671Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity
Q33748933Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells.
Q73631583Involvement of Fas receptor and not tumor necrosis factor-alpha receptor in ultraviolet-induced activation of acid sphingomyelinase
Q24679716Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
Q37228253Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis
Q43226057Isolated guinea pig gastric chief cells express tumour necrosis factor receptors coupled with the sphingomyelin pathway
Q40024215Kinase cascades regulating entry into apoptosis
Q37359497Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes.
Q36508071Lipids and the pathogenesis of Alzheimer's disease: is there a link?
Q36380942Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
Q41195420Looking beneath the surface: the cell death pathway of Fas/APO-1 (CD95).
Q40027324Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome c release from mitochondria leading to apoptosis
Q41282752Low Temperatures and Hypertonicity Do Not Block Cytokine-induced Stimulation of the Sphingomyelin Pathway but Inhibit Nuclear Factor-κB Activation
Q42990368Metabolism and apoptotic properties of elevated ceramide in HT29rev cells
Q41372733Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells
Q34074891Microbial pathogens and apoptotic anticancer therapy
Q41585278Minimizing cancer risk using molecular techniques: a review
Q34747143Mitochondria and ceramide: intertwined roles in regulation of apoptosis
Q34648811Mitochondria as sensors of sphingolipids
Q36259131Mitochondrial ceramide and the induction of apoptosis
Q40638238Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes
Q43557670Modulation of ceramide-induced NF-kappaB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidants.
Q33836328Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction
Q54163153Molecular species of sphingomyelin in sphingomyelinase-sensitive and sphingomyelinase-resistant pools of HL-60 cells.
Q41681702Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells
Q37625585Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.
Q28378267N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells
Q40993882NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR.
Q73713287Nerve growth factor induces sphingomyelin accumulation in pheochromocytoma cells
Q48411810Network analysis of arachidonic acid pathophysiology in human phagocytes and primary brain tumors
Q34269624Neutral ceramidase gene: role in regulating ceramide-induced apoptosis
Q24316872Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies
Q34085972Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle
Q34042899Neutral sphingomyelinase: past, present and future
Q74213121Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A
Q47891394Nitroxides tempol and tempo induce divergent signal transduction pathways in MDA-MB 231 breast cancer cells
Q34481861Novel pharmacological agents in clinical development for solid tumours
Q36664480Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells
Q24568285PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
Q40947234Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide
Q77457162Paracrine mechanisms of ovarian follicle apoptosis
Q33930354Physiology and pathophysiology of sphingolipid metabolism and signaling
Q48970037Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
Q41105989Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal
Q42442750Positive and negative regulation of JNK1 by protein kinase C and p42(MAP kinase) in adult rat hepatocytes
Q39596126Possible interactions between the NS-1 protein and tumor necrosis factor alpha pathways in erythroid cell apoptosis induced by human parvovirus B19.
Q40913274Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells
Q46465892Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism
Q40872435Production of ceramides causes apoptosis during early neural differentiation in vitro
Q36810836Programmed cell death in neurotumour cells involves the generation of ceramide
Q33832628Protein kinase C targeting in antineoplastic treatment strategies
Q40942508Protein kinase C-dependent anti-apoptotic mechanism that is associated with high sensitivity to anti-Fas antibody in ovarian cancer cell lines
Q77709040Radiation-induced apoptosis--the ceramide-SAPK signaling pathway and clinical aspects
Q45096250Radiosensitization of HL-60 human leukaemia cells by bryostatin-1 in the absence of increased DNA fragmentation or apoptotic cell death
Q41506389Regulation of Fas-mediated apoptosis
Q42034188Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
Q35707970Regulation of ceramide signaling by plasma membrane coenzyme Q reductases
Q41294365Regulation of the Fas apoptotic cell death pathway by Abl.
Q42436232Regulatory role of CD95 ligation on human B cells induced in vivo capable of spontaneous and high-rate Ig secretion
Q44582788Requirement for SAPK-JNK signaling in the induction of apoptosis by ribosomal stress in REH lymphoid leukemia cells
Q38289335Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells
Q24563429Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
Q42506351Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells
Q41992885Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating
Q36571858Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
Q48127954Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons
Q27022944Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes
Q40629891Second messengers. Sphingolipid signalling.
Q40494672Selective induction of apoptosis in MCF7 cancer-cell by targeted liposomes functionalised with mannose-6-phosphate.
Q55109349Selective reduction in alpha-hydroxypalmitic acid-containing sphingomyelin and concurrent increase in hydroxylated ceramides in murine skin tumors induced by an initiation-promotion regimen.
Q35917233Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
Q71918623Sphingomyelin-ceramide turnover in CD28 costimulatory signaling
Q33941924Sphingosine: a mediator of acute renal tubular injury and subsequent cytoresistance
Q41252542Step-down heating enhances the cytotoxicity of human tumour necrosis factor on murine and human tumour cell lines in vitro
Q38887432Targeting ceramide metabolism in obesity
Q44913883The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
Q42124606The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells
Q39596805The latency-related gene of bovine herpesvirus 1 inhibits programmed cell death
Q28611462The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis
Q61454987The topoisomerase inhibitors camptothecin and etoposide induce a CD95-independent apoptosis of activated peripheral lymphocytes
Q33606466Towards prediction and modulation of treatment response
Q41029352Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions
Q41807923Treatment of mouse melanoma cells with phorbol 12-myristate 13-acetate counteracts mannosylerythritol lipid-induced growth arrest and apoptosis
Q38346715Tumor necrosis factor alpha activates NF-kappaB in acid sphingomyelinase-deficient mouse embryonic fibroblasts
Q48870733Tumor necrosis factor alpha enhances oocyte/follicle apoptosis in the neonatal rat ovary
Q41890014Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.
Q40669397Tumor necrosis factor receptor-mediated signaling pathways
Q73899152Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step
Q38096833Using ASMase knockout mice to model human diseases
Q42990194Utilization of phosphatidylcholine and production of diradylglycerol as a consequence of sphingomyelin synthesis
Q35722794Viral activation and recruitment of metacaspases in the unicellular coccolithophore, Emiliania huxleyi

Search more.