| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1014966012 |
| P356 | DOI | 10.1023/A:1005590316064 |
| P698 | PubMed publication ID | 10399097 |
| P2093 | author name string | K Suzuki | |
| N Fujita | |||
| M T Vanier | |||
| H Nakayasu | |||
| J Tohyama | |||
| Y Oya | |||
| T Ezoe | |||
| P2860 | cites work | Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis | Q24679716 |
| Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their common gene | Q28186070 | ||
| Role of ceramide in cellular senescence | Q28271312 | ||
| Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals | Q28295232 | ||
| Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases | Q28585898 | ||
| Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway | Q34889125 | ||
| Assignment of the gene for human sphingolipid activator protein-2 (SAP-2) to chromosome 10. | Q35200397 | ||
| Identification of prosaposin as a neurotrophic factor | Q35799627 | ||
| Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides | Q36147091 | ||
| Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. | Q36798604 | ||
| Diagnosis of metachromatic leukodystrophy, Krabbe disease, and Farber disease after uptake of fatty acid-labeled cerebroside sulfate into cultured skin fibroblasts | Q36985153 | ||
| Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: biochemical signs of combined sphingolipidoses | Q38241614 | ||
| Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid | Q39914838 | ||
| Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis | Q41065043 | ||
| Turnover of endogenous ceramide in cultured normal and Farber fibroblasts. | Q41067055 | ||
| Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). | Q41233407 | ||
| Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. | Q41440948 | ||
| Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation | Q41700006 | ||
| Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation | Q41721364 | ||
| Additional biochemical findings in a patient and fetal sibling with a genetic defect in the sphingolipid activator protein (SAP) precursor, prosaposin. Evidence for a deficiency in SAP-1 and for a normal lysosomal neuraminidase | Q42071359 | ||
| Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells | Q42450545 | ||
| Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. | Q42555356 | ||
| Genetic analysis of control of proliferation in fibroblastic cells in culture. I. Isolation and characterization of mutants temperature-sensitive for proliferation or survival of untransformed diploid rat cell line 3Y1. | Q42823274 | ||
| Metabolism of cerebroside sulphate and subcellular distribution of its metabolites in cultured skin fibroblasts derived from controls, metachromatic leukodystrophy, globoid cell leukodystrophy and Farber disease | Q44736843 | ||
| Identification of the neurotrophic factor sequence of prosaposin | Q46255933 | ||
| Modulation of cell growth and differentiation by ceramide | Q46647894 | ||
| Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation. | Q48568860 | ||
| Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity | Q49155965 | ||
| Ceramide induces apoptosis in cultured mesencephalic neurons | Q49156263 | ||
| Apoptosis involved in density-dependent regulation of rat fibroblastic 3Y1 cell culture. | Q50533424 | ||
| Protection by prosaposin against ischemia-induced learning disability and neuronal loss. | Q52213537 | ||
| Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. | Q52520885 | ||
| The gene coding for a sphingolipid activator protein, SAP-1, is on human chromosome 10 | Q70072985 | ||
| Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts | Q70288563 | ||
| Programmed cell death induced by ceramide | Q70619078 | ||
| Role of lysosomal acid ceramidase in the metabolism of ceramide in human skin fibroblasts | Q70862552 | ||
| (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase | Q71119928 | ||
| Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane | Q71228956 | ||
| Farber's lipogranulomatosis. Report of a case and demonstration of an excess of free ceramide and ganglioside | Q71359805 | ||
| Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells | Q71367362 | ||
| Prosaposin facilitates sciatic nerve regeneration in vivo | Q71464564 | ||
| A family with combined Farber and Sandhoff, isolated Sandhoff and isolated fetal Farber disease: postnatal exclusion and prenatal diagnosis of Farber disease using lipid loading tests on intact cultured cells | Q71814795 | ||
| Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation | Q72334860 | ||
| Sphingolipid activator protein D (sap-D) stimulates the lysosomal degradation of ceramide in vivo | Q72425473 | ||
| Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphi | Q72921443 | ||
| Loss of ceramide production confers resistance to radiation-induced apoptosis | Q73221177 | ||
| Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue | Q74582933 | ||
| P433 | issue | 5 | |
| P921 | main subject | sphingolipids | Q410395 |
| ceramides | Q424213 | ||
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 649-662 | |
| P577 | publication date | 1999-06-01 | |
| P1433 | published in | Journal of Inherited Metabolic Disease | Q6295359 |
| P1476 | title | Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease | |
| P478 | volume | 22 |
| Q33629581 | An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis |
| Q37323862 | Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha, and JNK. |
| Q39644216 | Expression of δ-toxin by Staphylococcus aureus mediates escape from phago-endosomes of human epithelial and endothelial cells in the presence of β-toxin |
| Q28290521 | Glycosphingolipidoses: beyond the enzymatic defect |
| Q57817278 | Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis |
| Q33538932 | Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis |
| Q33930354 | Physiology and pathophysiology of sphingolipid metabolism and signaling |
| Q43717679 | Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells |
| Q55122433 | Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders. |
| Q36995806 | The Effect of Gromwell (Lithospermum erythrorhizon) Extract on the Stratum Corneum Hydration and Ceramides Content in Atopic Dermatitis Patients |
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