| scholarly article | Q13442814 |
| P50 | author | Lina M. Obeid | Q56565148 |
| Mark Venable | Q70808876 | ||
| P2093 | author name string | J Y Lee | |
| M J Smyth | |||
| A Bielawska | |||
| P2860 | cites work | THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS | Q28202269 |
| P433 | issue | 51 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ceramides | Q424213 |
| cellular senescence | Q9075999 | ||
| P304 | page(s) | 30701-30708 | |
| P577 | publication date | 1995-12-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Role of ceramide in cellular senescence | |
| P478 | volume | 270 |
| Q48539335 | 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis |
| Q92512973 | A Targeted Mass Spectrometric Analysis Reveals the Presence of a Reduced but Dynamic Sphingolipid Metabolic Pathway in an Ancient Protozoan, Giardia lamblia |
| Q40407198 | A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging |
| Q24675372 | A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death |
| Q33890589 | A hypothesis concerning a potential involvement of ceramide in apoptosis and acantholysis induced by pemphigus autoantibodies |
| Q33536846 | A reassessment of the telomere hypothesis of senescence |
| Q37061696 | A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis |
| Q38939824 | A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. |
| Q48225577 | Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders |
| Q46606270 | Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging |
| Q73214207 | Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging |
| Q44117717 | Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. |
| Q92205921 | Advances in determining signaling mechanisms of ceramide and role in disease |
| Q36882253 | Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention |
| Q35019556 | Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging |
| Q73740623 | Age-dependent modifications in rat hepatocyte antioxidant defense systems |
| Q41714155 | Aging and the cornea |
| Q36663043 | Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? |
| Q27310161 | Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain |
| Q47978602 | Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines |
| Q37066756 | Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta |
| Q34688159 | Are there roles for brain cell senescence in aging and neurodegenerative disorders? |
| Q34883222 | Bioactive sphingolipids: metabolism and function |
| Q37739704 | Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide |
| Q35852313 | Biologically active sphingolipids in cancer pathogenesis and treatment |
| Q39990649 | C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry. |
| Q35994344 | Calcium-independent phospholipases A2 and their roles in biological processes and diseases. |
| Q41561840 | Cell aging in vivo and in vitro |
| Q33914271 | Cell proliferation and apoptosis in the immune system in the elderly |
| Q41013768 | Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. |
| Q48167130 | Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease |
| Q38021345 | Ceramide function in the brain: when a slight tilt is enough. |
| Q37797406 | Ceramide in Stress Response |
| Q28384389 | Ceramide induced mitophagy and tumor suppression |
| Q41910048 | Ceramide induces a loss in cytosolic peroxide levels in mononuclear cells |
| Q40894240 | Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts. |
| Q44033506 | Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression |
| Q44018997 | Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis |
| Q44370232 | Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis |
| Q34984863 | Ceramide: second messenger or modulator of membrane structure and dynamics? |
| Q38124070 | Ceramides in the pathophysiology of the anterior segment of the eye. |
| Q43551073 | Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro |
| Q44409392 | Characterization of Serine Palmitoyltransferase in Normal Human Tissues |
| Q40091584 | Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells |
| Q42724161 | Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry |
| Q34688733 | Complexation of c6-ceramide with cholesteryl phosphocholine - a potent solvent-free ceramide delivery formulation for cells in culture. |
| Q73879335 | Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum |
| Q34035741 | Cryptococcus neoformans modulates extracellular killing by neutrophils |
| Q36734546 | DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. |
| Q41079756 | Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts |
| Q34947370 | Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance |
| Q40202977 | Dissecting the senescence-like program in tumor cells activated by Ras signaling |
| Q39577917 | Distinct pathways for tumor necrosis factor alpha and ceramides in human cytomegalovirus infection. |
| Q34612187 | Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease |
| Q41065566 | Effect of insoluble extracellular matrix molecules on Fas expression in epithelial cells |
| Q37621934 | Effects of lipid interactions on model vesicle engulfment by alveolar macrophages |
| Q35627763 | Effects of sphingosine 2N- and 3O-methylation on palmitoyl ceramide properties in bilayer membranes. |
| Q61450148 | Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study |
| Q74297486 | Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts |
| Q33855451 | Epigenetic aspects of cellular senescence |
| Q42986496 | Evidence against an early signalling role for ceramide in Fas-mediated apoptosis |
| Q26863646 | Evolving concepts in cancer therapy through targeting sphingolipid metabolism |
| Q89597540 | Extracellular Vesicles Derived from Senescent Fibroblasts Attenuate the Dermal Effect on Keratinocyte Differentiation |
| Q34648165 | First comparative transcriptomic analysis of wild adult male and female Lutzomyia longipalpis, vector of visceral leishmaniasis |
| Q44568978 | Genotoxicity, recombinogenicity and cellular preneoplasic transformation induced by vitamin A supplementation |
| Q33886495 | Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death |
| Q33861622 | HFE gene variants, iron, and lipids: a novel connection in Alzheimer's disease |
| Q37420053 | High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors |
| Q53435154 | Identification and evaluation of neutral sphingomyelinase 2 inhibitors. |
| Q28143167 | Identification of multiple forms of membrane-associated neutral sphingomyelinase in bovine brain |
| Q50050920 | Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics |
| Q37610199 | Impaired energy metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes |
| Q33555622 | Increase in sphingolipid catabolic enzyme activity during aging |
| Q87389448 | Inducible transient expression of Smpd3 prevents early lethality in fro/fro mice |
| Q30983475 | Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells. |
| Q92994454 | Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence |
| Q42986851 | Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells |
| Q38921081 | Interactions of meningococcal virulence factors with endothelial cells at the human blood-cerebrospinal fluid barrier and their role in pathogenicity |
| Q36157119 | Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells |
| Q31857599 | Is increased arachidonic acid release a cause or a consequence of replicative senescence? |
| Q34955959 | LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery |
| Q77614144 | Limits to lifespan |
| Q64098656 | Links between accelerated replicative cellular senescence and down-regulation of SPHK1 transcription |
| Q34492882 | Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts |
| Q33435148 | Liquid chromatography-mass spectrometry for comprehensive profiling of ceramide molecules in human hair. |
| Q40953556 | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease |
| Q77366607 | Lysophosphatidylcholine activates mitogen-activated protein kinases by a tyrosine kinase-dependent pathway in bovine aortic endothelial cells |
| Q38095525 | Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation |
| Q64981840 | Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues. |
| Q35850403 | Metabolic Conversion of Ceramides in HeLa Cells - A Cholesteryl Phosphocholine Delivery Approach |
| Q28543389 | Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis |
| Q41728046 | Modulation of cell signalling by ceramides. |
| Q42455822 | Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds |
| Q34956047 | Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ) |
| Q35878177 | Novel advances in shotgun lipidomics for biology and medicine |
| Q56964057 | Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation |
| Q24324559 | Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a |
| Q47281580 | Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology? |
| Q77962326 | P53 mediates ceramide-induced apoptosis in SKN-SH cells |
| Q37895205 | PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism |
| Q40947234 | Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide |
| Q33698839 | Phospholipase D in cellular senescence |
| Q43255168 | Phospholipase D modulation by ceramide in senescence. |
| Q26744221 | Positive and negative effects of cellular senescence during female reproductive aging and pregnancy |
| Q22003910 | Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling |
| Q28265743 | Principles of bioactive lipid signalling: lessons from sphingolipids |
| Q57364501 | Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles |
| Q37229309 | Progeroid syndromes: probing the molecular basis of aging? |
| Q50223816 | Progressive white matter atrophy with altered lipid profiles is partially reversed by short-term abstinence in an experimental model of alcohol-related neurodegeneration |
| Q30845700 | Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain |
| Q44658822 | Quantitation and molecular species determination of diacylglycerols, phosphatidylcholines, ceramides, and sphingomyelins with gas chromatography |
| Q37439524 | Regulation of ceramide biosynthesis by TOR complex 2. |
| Q38719185 | Regulation of lipids is central to replicative senescence |
| Q37478008 | Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation |
| Q64262055 | Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time |
| Q42357190 | Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism |
| Q36745834 | Resection of non-small cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system |
| Q39239252 | Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts. |
| Q40825386 | Retinol supplementation induces DNA damage and modulates iron turnover in rat Sertoli cells. |
| Q39408464 | Role of neutral ceramidase in colon cancer |
| Q57177438 | Role of sphingolipids in senescence: implication in aging and age-related diseases |
| Q28476635 | Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans |
| Q24657499 | Roles of bioactive sphingolipids in cancer biology and therapeutics |
| Q77669509 | Selective involvement of caspase-3 in ceramide induced apoptosis in AK-5 tumor cells |
| Q82538433 | Senescence in cells in aseptic loosening after total hip replacement |
| Q42018503 | Senescence-accelerated Mice (SAMs) as a Model for Brain Aging and Immunosenescence. |
| Q92019365 | Senescent cell clearance by the immune system: Emerging therapeutic opportunities |
| Q33527140 | Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis |
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| Q41377547 | Signal transduction in cellular senescence. |
| Q42904577 | Simultaneous Quantification of Sphingolipids in Small Quantities of Liver by LC-MS/MS. |
| Q44228255 | Simultaneous quantitative determination method for ceramide species from crude cellular extracts by high-performance liquid chromatography-thermospray mass spectrometry |
| Q39961635 | Sphingolipid metabolism is a crucial determinant of cellular fate in nonstimulated proliferating Madin-Darby canine kidney (MDCK) cells |
| Q37586487 | Sphingolipids and lifespan regulation |
| Q36462123 | Sphingolipids: regulators of crosstalk between apoptosis and autophagy |
| Q37799400 | Sphingolipids: the nexus between Gaucher disease and insulin resistance |
| Q30370634 | Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice |
| Q37909176 | Sphingosine 1-phosphate in coagulation and inflammation. |
| Q38177794 | Sphingosine kinase and sphingosine-1-phosphate: regulators in autoimmune and inflammatory disease |
| Q38448843 | Sphingosine-1-phosphate metabolism: A structural perspective |
| Q60596773 | Study of sphingolipids oxidation by ESI tandem MS |
| Q33967293 | Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells |
| Q46781276 | Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase |
| Q44188820 | Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status |
| Q104795161 | Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides |
| Q34224763 | Telomeres, replicative senescence and human ageing |
| Q74339954 | The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats |
| Q28295918 | The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells |
| Q38166684 | The glycosphingolipid hydrolases in the central nervous system |
| Q36864864 | The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. |
| Q73370522 | The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells |
| Q38915115 | Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism |
| Q61928361 | Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes |
| Q43251117 | Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. |
| Q33681203 | Use of sphingolipid analogs: benefits and risks |
| Q61797514 | Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells |
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