Advances in determining signaling mechanisms of ceramide and role in disease

scientific article published on 07 March 2019

Advances in determining signaling mechanisms of ceramide and role in disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1194/JLR.S092874
P932PMC publication ID6495170
P698PubMed publication ID30846529

P2093author name stringLina M Obeid
Fabiola N Velazquez
Jeffrey L Stith
P2860cites workHuman homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeastQ24309458
Dihydroceramides: From Bit Players to Lead ActorsQ26851948
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Role of ceramide in cellular senescenceQ28271312
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Ceramide-rich platforms in transmembrane signalingQ35633883
Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II.Q36149981
Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell DeathQ36283299
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's diseaseQ36604677
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chainQ36620822
Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced ObesityQ36727429
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagyQ36946878
Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cellsQ37147627
Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chainQ37590278
Ceramide synthases as potential targets for therapeutic intervention in human diseasesQ38136056
Role of neutral ceramidase in colon cancerQ39408464
Ceramide Produces Apoptosis Through Induction of p27kip1by Protein Phosphatase 2A-dependent Akt Dephosphorylation in PC-3 Prostate Cancer CellsQ39643015
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophilsQ41126508
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophilsQ41388808
Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosisQ41682271
Role of sphingomyelinase in mitochondrial ceramide accumulation during reperfusionQ46507820
Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human gliomaQ47142782
Sphingolipids and their metabolism in physiology and diseaseQ47374235
Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.Q47407341
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intoleranceQ47431942
Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis.Q47595409
Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytesQ47615458
Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.Q47673905
A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.Q47712397
Ceramide Is Metabolized to Acylceramide and Stored in Lipid DropletsQ47951459
Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide SystemQ47972469
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of ColitisQ48157708
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.Q51765146
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.Q52319633
Characterization of Plasma Membrane Ceramides by Super-Resolution Microscopy.Q53731153
Ceramide Remodeling and Risk of Cardiovascular Events and Mortality.Q55431160
Role of sphingolipids in senescence: implication in aging and age-related diseasesQ57177438
C-ceramide is a natural regulatory ligand of p53 in cellular stress responseQ57295410
Ceramide-mediated clustering is required for CD95-DISC formationQ57369954
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolismQ58488814
Effect of ceramide structure on membrane biophysical properties: The role of acyl chain length and unsaturationQ59153608
Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem CellsQ61797514
The Physical Properties of Ceramides in MembranesQ88266807
CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin ResistanceQ88388236
Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cellsQ88693120
nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe-/- MiceQ88792982
Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization MechanismQ88837367
CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin ResistanceQ90865174
The relevance of ceramides and their synthesizing enzymes for multiple sclerosisQ91467610
Visualizing bioactive ceramidesQ91857226
P433issue5
P921main subjectceramidesQ424213
P304page(s)913-918
P577publication date2019-03-07
P1433published inJournal of Lipid ResearchQ6295449
P1476titleAdvances in determining signaling mechanisms of ceramide and role in disease
P478volume60

Reverse relations

Q90648068Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomographycites workP2860

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