Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II.

scientific article

Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1212/WNL.0B013E318264E380
P932PMC publication ID3414665
P698PubMed publication ID22815558

P50authorLinda P. FriedQ6551880
Karen Bandeen-RocheQ42055725
Marilyn S. AlbertQ56861968
Michelle M MielkeQ60909929
Constantine G. LyketsosQ91213781
Peter V. RabinsQ112424479
P2093author name stringNorman J Haughey
Michelle C Carlson
Sevil Yasar
Vijay Varma
Greg Harris
Eric B Schneider
Jin Xia
Veera Vankata Ratnam Bandaru
P2860cites workMetabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomicsQ21560953
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranesQ24532064
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseQ27860795
Deregulation of sphingolipid metabolism in Alzheimer's diseaseQ33693061
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesisQ34007818
Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume lossQ34106300
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor proteinQ34649008
Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?Q35086073
Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's diseaseQ36004699
Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathwayQ36321788
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's diseaseQ36604677
Frequency and course of mild cognitive impairment in a multiethnic communityQ36643547
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brainQ37379675
Serum sphingomyelins and ceramides are early predictors of memory impairmentQ37437931
Sphingolipids and insulin resistance: the five Ws.Q37705954
Amyloid beta oligomerization is induced by brain lipid raftsQ40276012
Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis.Q40482351
Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complexQ40858625
Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloidQ44014100
Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesisQ44163309
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesisQ44370232
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathwayQ44400926
Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factorsQ44435276
Association of ceramides in human plasma with risk factors of atherosclerosisQ44772533
Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters.Q45931841
Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration.Q46649324
Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitroQ46663698
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilinQ46755710
Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-beta peptideQ46814799
Alzheimer peptides perturb lipid-regulating enzymesQ46873173
Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?Q48251608
Role of MAPK in ceramide-induced cell death in primary cultured astrocytes from mouse embryonic brain.Q48787493
Association between executive attention and physical functional performance in community-dwelling older women.Q51980484
Ganglioside GM1-Mediated Amyloid-beta Fibrillogenesis and Membrane Disruption†Q57365077
Preclinical mobility disability predicts incident mobility disability in older womenQ73554971
Plasma sphingomyelin and subclinical atherosclerosis: findings from the multi-ethnic study of atherosclerosisQ83149821
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
ceramidesQ424213
P304page(s)633-641
P577publication date2012-07-18
P1433published inNeurologyQ1161692
P1476titleSerum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II.
P478volume79

Reverse relations

cites work (P2860)
Q47146081A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise.
Q37692220APP Function and Lipids: A Bidirectional Link
Q33964297Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease
Q92205921Advances in determining signaling mechanisms of ceramide and role in disease
Q92082191Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases
Q53331705Alzheimer disease: blood-based biomarkers in AD--a silver lining on the horizon.
Q92300845An Exploratory Phase IIa Study of the PPAR delta/gamma Agonist T3D-959 Assessing Metabolic and Cognitive Function in Subjects with Mild to Moderate Alzheimer's Disease
Q40444820Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease
Q91194967Associations of plasma very-long-chain SFA and the metabolic syndrome in adults
Q26740418Autoantibodies in Alzheimer's disease: potential biomarkers, pathogenic roles, and therapeutic implications
Q34223486Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices.
Q93075146Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course
Q28547451Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties
Q101476188Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer's disease transgenic mice by functioning as a metabolic probe
Q38607507Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies
Q28087030Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
Q35065194Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study
Q34422726Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics
Q34223125Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease
Q33752058Circulating biomarkers that predict incident dementia
Q92721755Circulating ceramide ratios and risk of vascular brain aging and dementia
Q50481966Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans.
Q93186219Comparison of Single Phase and Biphasic Extraction Protocols for Lipidomic Studies Using Human Plasma
Q38833111Compounds of the sphingomyelin-ceramide-glycosphingolipid pathways as secondary messenger molecules: new targets for novel therapies for fatty liver disease and insulin resistance
Q36768801Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease?
Q47407341Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.
Q36409995Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species
Q64228448Developmental Comparison of Ceramide in Wild-Type and Mouse Brains and Sera
Q46426783Differential regulation of sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice administered sphingolipid modulating agents.
Q35008258Emerging biomarkers in cognition
Q58803874Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration
Q97649423Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins
Q46000358Genetic variation modifies risk for neurodegeneration based on biomarker status.
Q36436743HDL-cholesterol and apolipoproteins in relation to dementia
Q37389500Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab.
Q36166971Interictal, circulating sphingolipids in women with episodic migraine: A case-control study
Q34019193Is Alzheimer's disease a systemic disease?
Q39352421Lipidomic Profiles in Diabetes and Dementia.
Q90692297Low Plasma Sphingomyelin Levels Show a Weak Association with Poor Neurological Outcome in Cardiac Arrest Patients: Results from the Prospective, Observational COMMUNICATE Trial
Q42573873Markedly perturbed hematopoiesis in acid ceramidase deficient mice
Q39181900Metabolomic-guided discovery of Alzheimer's disease biomarkers from body fluid.
Q33627250Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Q47099182Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
Q30363059Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse
Q39320214Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.
Q36973077Peripheral sphingolipids are associated with variation in white matter microstructure in older adults
Q46563505Plasma Ceramides and Neuropsychiatric Symptoms of Alzheimer's Disease
Q37091714Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study
Q34994293Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study
Q36855949Plasma sphingolipid changes with autopsy-confirmed Lewy Body or Alzheimer's pathology
Q90589264Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase
Q38125769Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes.
Q26828606Recent advances in the application of metabolomics to Alzheimer's Disease
Q38262594Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease
Q57177438Role of sphingolipids in senescence: implication in aging and age-related diseases
Q37109693Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
Q90089057Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
Q89983254Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome
Q46753548Skeletal muscle ceramide species in men with abdominal obesity
Q37586487Sphingolipids and lifespan regulation
Q90010373Sphingolipids as Biomarkers of Disease
Q57070720Sphingolipids in neurodegeneration (with focus on ceramide and S1P)
Q47619472Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications
Q36121819The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden
Q40401973The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging.
Q36209750The Effects of Long-Term Saturated Fat Enriched Diets on the Brain Lipidome.
Q43988916The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease
Q49917617The serum metabolomics signature of Type 2 Diabetes is obscured in Alzheimer's Disease
Q41687237Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection
Q61797514Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

Search more.