Ceramide in apoptosis: an overview and current perspectives

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Ceramide in apoptosis: an overview and current perspectives is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S1388-1981(02)00331-1
P698PubMed publication ID12531544

P50authorYusuf A. HannunQ87620042
P2093author name stringCharles E Chalfant
Benjamin J Pettus
P2860cites workAnalysis of functional domains of angiotensin II type 2 receptor involved in apoptosisQ22010261
Molecular cloning and characterization of a human mitochondrial ceramidaseQ22253989
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinaseQ22254143
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramideQ24291239
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterizationQ24294548
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?Q24319856
FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinaseQ24323995
Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber diseaseQ24336488
The use of diglyceride kinase for quantifying ceramideQ77875075
Stress signals for apoptosis: ceramide and c-Jun kinaseQ77900365
Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2AQ77985300
Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinaseQ78037718
A possible role of nuclear ceramide and sphingosine in hepatocyte apoptosis in rat liverQ78053115
Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.Q54062670
Distinct functions of SR proteins in alternative pre-mRNA splicing.Q55066190
Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.Q55475374
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
Ceramide glycosylation potentiates cellular multidrug resistanceQ57373871
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosisQ57373873
Activation energies for gas-phase dissociations of multiply charged ions from electrospray ionization mass spectrometryQ58069614
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen SpeciesQ58116814
BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1Q59123101
Identification of Heterogeneous Ribonucleoprotein A1 as a Novel Substrate for Protein Kinase C ζQ59123103
c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells.Q64967336
Programmed cell death induced by ceramideQ70619078
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiationQ71743133
Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1Q73006592
Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometryQ73051257
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinaseQ73127880
Quantitative determination of ceramide using diglyceride kinaseQ73170808
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosisQ73596247
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramideQ73717907
CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibitionQ73717944
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2Q73919781
Induction of p53-independent p21 during ceramide-induced G1 arrest in human hepatocarcinoma cellsQ73940009
Activation of ERK1/2 and cPLA(2) by the p55 TNF receptor occurs independently of FANQ74062072
Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labellingQ74079499
Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cellsQ74215676
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell deathQ74473415
Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cellsQ74583650
Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivationQ77472042
Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cellsQ77545172
Cathepsin D targeted by acid sphingomyelinase-derived ceramideQ24529823
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrestQ24563429
p53-dependent ceramide response to genotoxic stressQ24564604
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acidQ24568285
Modulation of Akt kinase activity by binding to Hsp90Q24648565
Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell deathQ24676003
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1pQ27932220
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosisQ28139061
Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type IQ28204289
SR proteins: a conserved family of pre-mRNA splicing factorsQ28240185
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2AQ28291327
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signalsQ28295232
Purification and characterization of a novel ceramidase from Pseudomonas aeruginosaQ28492756
Identification and characterization of a sphingolipid delta 4-desaturase familyQ28506937
Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidasesQ28513560
Tumor necrosis factor-  induces adhesion molecule expression through the sphingosine kinase pathwayQ29041393
SR proteins and splicing controlQ29619936
Activation of a nuclear sphingomyelinase in radiation-induced apoptosisQ31812327
Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondriaQ31864172
Signalling sphingomyelinases: which, where, how and why?Q33601457
Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimensQ33914230
Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated stateQ33958497
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicityQ33980970
Involvement of sphingomyelinases in TNF signaling pathwaysQ34042929
Current methods for the identification and quantitation of ceramides: an overviewQ34057367
Protein kinase B (PKB/Akt)--a key regulator of glucose transport?Q34189344
Enzymes of sphingolipid metabolism: from modular to integrative signalingQ34220989
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.Q34420769
Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.Q34438239
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathwayQ34889125
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.Q36050995
Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membraneQ36211654
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificityQ36268125
Association of phosphorylated serine/arginine (SR) splicing factors with the U1-small ribonucleoprotein (snRNP) autoantigen complex accompanies apoptotic cell deathQ36400294
Fas-induced apoptosis of T cells occurs independently of ceramide generationQ36654745
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinaseQ37477854
Bcl-2 interrupts the ceramide-mediated pathway of cell death.Q37583838
Sphingolipid metabolism in cultured fibroblasts: microscopic and biochemical studies employing a fluorescent ceramide analogueQ37610409
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alphaQ37617716
Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factorsQ37685703
An update of the enzymology and regulation of sphingomyelin metabolismQ37923512
Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthaseQ38323889
Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cellsQ38525013
TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cellsQ40771853
Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cellsQ40776199
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitateQ40778321
Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosisQ40850451
Measurement of ceramide synthase activityQ40865787
Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.Q40869425
Ceramide as an activator lipid of cathepsin D.Q40874792
Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblastsQ40881783
Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosisQ40922175
Mass spectrometric identification of increased C16 ceramide levels during apoptosisQ40922788
Involvement of de novo ceramide biosynthesis in lymphotoxin-induced oligodendrocyte deathQ40936702
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosisQ41008797
Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?Q41035572
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.Q41035943
Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholineQ41036914
Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cellsQ41100173
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosisQ41128299
Phosphorylation of Raf by ceramide-activated protein kinaseQ41270560
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signallingQ42034188
Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.Q42441554
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acidQ42474499
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitateQ42476162
Mouse anti-ceramide antiserum: a specific tool for the detection of endogenous ceramideQ42507051
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphateQ42556020
Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidneyQ42648568
Metabolism and apoptotic properties of elevated ceramide in HT29rev cellsQ42990368
Kinase suppressor of Ras signals through Thr269 of c-Raf-1.Q43514105
Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondriaQ43559569
p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cellsQ43583302
Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidineQ43615470
Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramideQ43646549
The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress.Q43654457
Effect of affinity for droplet surfaces on the fraction of analyte molecules charged during electrospray droplet fissionQ43769736
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.Q43860697
Purification and characterization of ceramide-activated protein phosphatasesQ47710075
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fractionQ47877695
Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell deathQ47954345
Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brainQ48111911
CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis.Q51082157
Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat.Q52524724
Ceramide enables fas to cap and kill.Q52542714
Analysis of sphingomyelin, glucosylceramide, ceramide, sphingosine, and sphingosine 1-phosphate by tandem mass spectrometry.Q52926527
CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.Q53435443
P433issue2-3
P407language of work or nameEnglishQ1860
P921main subjectceramidesQ424213
apoptotic processQ14599311
P304page(s)114-125
P577publication date2002-12-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleCeramide in apoptosis: an overview and current perspectives
P478volume1585

Reverse relations

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Q39471980KLF6/Sp1 initiates transcription of the tmsg-1 gene in human prostate carcinoma cells: an exon involved mechanism
Q53247481Knock-out of β-glucosidase 2 has no influence on dextran sulfate sodium-induced colitis.
Q39132798Knockdown of core binding factorβ alters sphingolipid metabolism
Q34403752LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia
Q54450465Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium.
Q40467658Light at the End of the "TUNEL"? Role of Ceramide in Seizure-induced Programmed Cell Death.
Q82136424Lipotoxicity in the heart
Q33435148Liquid chromatography-mass spectrometry for comprehensive profiling of ceramide molecules in human hair.
Q36580354Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
Q43154877Locus-specific gene expression pattern suggests a unique propagation strategy for a giant algal virus
Q42426530Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore
Q33909832Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death
Q24633453Mammalian ceramide synthases
Q34339067Mass spectrometry-based quantitative metabolomics revealed a distinct lipid profile in breast cancer patients.
Q54203079Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins.
Q35060329Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells
Q34632669Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways
Q34439404Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets
Q27653166Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase
Q27932540Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation
Q35850403Metabolic Conversion of Ceramides in HeLa Cells - A Cholesteryl Phosphocholine Delivery Approach
Q40390901Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD.
Q57364601Metabolism and physiological functions of sphingolipids
Q36259131Mitochondrial ceramide and the induction of apoptosis
Q34537129Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice
Q40827049Modulation of host ROS metabolism is essential for viral infection of a bloom-forming coccolithophore in the ocean.
Q55663256Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance.
Q89967597Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer
Q52593622Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.
Q61758664Molecular biology in diagnostic histopathology. Part 3: signal transduction
Q37625399Molecular features of neural stem cells enable their enrichment using pharmacological inhibitors of survival-promoting kinases
Q46891967Molecular-dynamics simulation of a ceramide bilayer
Q36980340Multi-functional nanocarriers to overcome tumor drug resistance
Q35136562Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology
Q33923721Multiple roles for sphingolipids in steroid hormone biosynthesis
Q36790146Myocardial metabolism and cardiac performance in obesity and insulin resistance
Q38234908Nanodrug delivery in reversing multidrug resistance in cancer cells
Q50058499Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice
Q99554200Neutral ceramidase is a marker for cognitive performance in rats and monkeys
Q24634655Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)
Q38726003New Aspects of Silibinin Stereoisomers and their 3-O-galloyl Derivatives on Cytotoxicity and Ceramide Metabolism in Hep G2 hepatocarcinoma Cell Line
Q34373087New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway
Q36526990Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents
Q36498966Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids
Q57131204Novel glucosylceramide synthase inhibitor based prodrug copolymer micelles for delivery of anticancer agents
Q46461035Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.
Q37925819Nuclear sphingolipid metabolism
Q58566319Overexpression of acid-Ceramidase (ASAH1) Protects Retinal Cells (ARPE19) from Oxidative Stress
Q36253615Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: implications for multiple sclerosis
Q37041154Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress
Q36628167Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling.
Q40432463Phosphorylation of Bad is not essential for PKB-mediated survival signaling in hemopoietic cells
Q36950921Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
Q40062826Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy
Q92133797Pkh1p-Ypk1p and Pkh1p-Sch9p Pathways Are Activated by Acetic Acid to Induce a Mitochondrial-Dependent Regulated Cell Death
Q89530316Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study
Q46453140Potential role of sphingosine 1-phosphate in the pathogenesis of rheumatoid arthritis
Q42044971Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta
Q48512547Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1.
Q44397902Protection by D609 through cell-cycle regulation after stroke
Q41841689Protein kinase C-δ isoform mediates lysosome labilization in DNA damage-induced apoptosis
Q40074168Protein-sphingolipid interactions within cellular membranes
Q42928858Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana
Q34320069Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice
Q52814701Quantitative structural characterization of phosphatidylinositol phosphates from biological samples.
Q37494793RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance.
Q37335620Rapid Detection of Necrosis in Breast Cancer with Desorption Electrospray Ionization Mass Spectrometry
Q39697531Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells
Q34559806Regulating survival and development in the retina: key roles for simple sphingolipids
Q36211046Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway.
Q28384330Regulation of mitochondrial ceramide distribution by members of the BCL-2 family
Q34745605Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous system
Q36562936Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
Q37704672Renal Medulla is More Sensitive to Cisplatin than Cortex Revealed by Untargeted Mass Spectrometry-Based Metabolomics in Rats
Q35050155Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells
Q42742597Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells
Q42027274Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Q24801508Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review
Q40439690Role of ceramide in Ca2+-sensing receptor-induced apoptosis
Q36403166Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis
Q24657499Roles of bioactive sphingolipids in cancer biology and therapeutics
Q36293021SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α
Q34390521Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis
Q39031586Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell
Q40571355Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity
Q43159538Simultaneous HPLC analysis of ceramide and dihydroceramide in human hairs
Q42468437Singlet oxygen-induced attenuation of growth factor signaling: possible role of ceramides
Q35778875Sphingolipid and ceramide homeostasis: potential therapeutic targets
Q36898608Sphingolipid metabolism and obesity-induced inflammation
Q50079745Sphingolipid pathway enzymes modulate cell fate and immune responses
Q26992148Sphingolipid signaling in metabolic disorders
Q37808219Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
Q38045551Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure
Q36533617Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex.
Q39880179Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.
Q34810283Sphingosine kinase localization in the control of sphingolipid metabolism
Q38408286Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells
Q39320764Sphingosine metabolism as a therapeutic target in cutaneous melanoma.
Q85356970Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles
Q37571963Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert
Q44509765Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta
Q38339310Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages
Q90614042Splicing factor SRSF1 controls T cell homeostasis and its decreased levels are linked to lymphopenia in systemic lupus erythematosus
Q91714604Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer
Q36559850Structure and function of glycosphingolipids and sphingolipids: recollections and future trends
Q36808041Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
Q43119491Synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds
Q34695541Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA
Q40189949Synthesis of 7-oxasphingosine and -ceramide analogues and their evaluation in a model for apoptosis
Q61454328TNFα mediated ceramide generation triggers cisplatin induced apoptosis in B16F10 melanoma in a PKCδ independent manner
Q35756892TRAIL and ceramide.
Q92711440Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress
Q84578277Temporal expression profiles of ceramide and ceramide-related genes in wild-type and mPer1/mPer2 double knockout mice
Q35973562The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.
Q37710735The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?
Q33466611The effect of hydrostatic pressure on model membrane domain composition and lateral compressibility.
Q44913883The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
Q37688434The interplay between bioactive sphingolipids and steroid hormones
Q49913969The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro.
Q40222818The murine TRAIL receptor signals caspase-independent cell death through ceramide
Q33737469The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.
Q39949537The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis
Q46445861The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.
Q38915115Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism
Q48197247Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c+ Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics
Q64937828Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects.
Q40547157Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death
Q49399657Translational Aspects of Sphingolipid Metabolism in Renal Disorders
Q36283299Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death
Q90074713Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
Q36199812oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages.

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